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Catalog Number:
(75933-582)
Supplier:
Rockland Immunochemical
Description:
Vitamin K epoxide reductase complex subunit 1 (VKORC1) is the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form which is essential for blood clotting. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is VKORC1 that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance.
Catalog Number:
(75930-170)
Supplier:
Rockland Immunochemical
Description:
Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells (1). MYH8 (myosin, heavy chain 8, skeletal muscle, perinatal) is a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction (2,3). This gene is predominantly expressed in fetal skeletal muscle. MYH8 is regulated by phosphorylation via myosin light chain kinase (MLCK) and by intracellular Ca2+ concentrations (3). A mutation in this gene results in trismus-pseudocamptodactyly syndrome (4).
Supplier:
BeanTown Chemical
Description:
CAS: 633-03-4; EC No: 211-190-1; MDL No: MFCD00011880; RTECS: BP6825000
Crystalline; Molecular Formula: C27H34N2O4S; MW: 485.63
Melting Point: 210° (decomposes)
Catalog Number:
(10802-570)
Supplier:
Rockland Immunochemical
Description:
Ectodysplasin A (EDA1) is a member of the TNF-related ligand family involved in the early epithelial-mesenchymal interaction that regulates ectodermal appendage formation (1). It is a trimeric type II membrane protein that co-localizes with cytoskeletal structures at the lateral and apical surfaces of cells and can be expressed as eight alternatively spliced isoforms in hair follicles and in the epidermis of adult skin (2,3). EDAs are required during development, and loss or mutation of EDA1 results in a group of developmental disorders identified as ectodermal dysplasia type 1 (4,5).
Catalog Number:
(10314-322)
Supplier:
Bioss
Description:
C9orf23 (chromosome 9 open reading frame 23) is a 163 amino acid protein that belongs to the histone-like Alba family and is encoded by a gene that maps to human chromosome 9p13.3. Chromosome 9 consists of about 145 million bases, represents 4% of the human genome and encodes nearly 900 genes. Thought to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias.
Catalog Number:
(75834-806)
Supplier:
Restek
Description:
Benzidine Mix (2 components), 605 Benzidines Calibration Mix, Concentration: 2,000 ug/mL each in methylene chloride, Components:Benzidine (92-87-5), 3,3'-Dichlorobenzidine (91-94-1), Minimum shelf life: 6 months
Supplier:
Matrix Scientific
Description:
Benzyl chloromethyl sulfide ≥97%
Catalog Number:
(SXS-3919)
Supplier:
SPEX CERTIPREP LLC
Description:
Single-Component organic standards.
Catalog Number:
(76009-924)
Supplier:
Prosci
Description:
This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined.
Supplier:
TCI America
Description:
CAS Number: 7338-27-4
MDL Number: MFCD00021713 Molecular Formula: C6H8O4 Molecular Weight: 144.13 Purity/Analysis Method: >98.0% (GC,T) Form: Crystal Boiling point (°C): 149 Melting point (°C): 72
Catalog Number:
(75928-890)
Supplier:
Rockland Immunochemical
Description:
Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet.
Catalog Number:
(75835-426)
Supplier:
Restek
Description:
The mixture consists of benzene (2 μg/ml), chloroform (60 μg/ml), 1,4-dioxane (380 μg/ml), methylene chloride (dichloromethane) (600 μg/ml) and trichloroethene (80 μg/ml).
Supplier:
MilliporeSigma
Description:
SupraSolv® MS is dedicated for use in gas chromatography coupled with mass spectrometric detection. SupraSolv® solvents offer the largest specified retention time range, a clear baseline and a minimal signal-to-noise ratio leading to reliable and reproducible analysis results. This method is used e. g. for the analysis of dioxins and furans (PCDD/PCDF) in food and water samples or for the determination of PAH (polycyclic aromatic hydrocarbons) in food. Also commonly used in QuEChERS pesticide residue analysis.
Catalog Number:
(76117-442)
Supplier:
Bioss
Description:
C12orf23 (chromosome 12 open reading frame 23), also known as FLJ11721, FLJ13959 or MGC17943, is a 116 amino acid multi-pass membrane protein belonging to the UPF0444 family. C12orf23 is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a number of skeletal deformities, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy.
Catalog Number:
(80016-986)
Supplier:
MilliporeSigma
Description:
3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl
Supplier:
AMBEED, INC
Description:
2-Chlorotrityl Chloride Resin 0.4-3.0 mmol/g 100-200 mesh, 1% DVB
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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