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4-(2-Bromo-4-isopropylphenoxy)piperidine+hydrochloride
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4-(2-Bromo-4-isopropylphenoxy)piperidine+hydrochloride
Catalog Number:
(10300-196)
Supplier:
Bioss
Description:
G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097).
Supplier:
AMBEED, INC
Description:
(4-Iodophenyl)diphenylphosphane, Purity: 98%, CAS Number: 440111-10-4, Appearance: White to yellow powder or crystals, Storage: Keep in dark place, Inert atmosphere, Room temperature, Size: 100MG
Supplier:
AOB CHEM USA
Description:
1-(5-Bromo-2-fluoro-3-iodophenyl)ethanone ≥97%
Supplier:
AOB CHEM USA
Description:
(3-Chloro-2-fluoro-5-iodophenyl)(methyl)sulfane ≥97%
Catalog Number:
(80058-790)
Supplier:
MilliporeSigma
Description:
(Trp). White solid. Purity: >= 98% by titration. Soluble in H2O. RTECS YN6130000, CAS 73-22-3, M.W. 204.2. WARNING! May be carcinogenic/teratogenic.
Supplier:
AMBEED, INC
Description:
3'-Iodoacetophenone 98%
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 050804-500MG , MDL Number: MFCD13561184
Supplier:
AOB CHEM USA
Description:
Methyl(2,3,4-trifluoro-5-iodophenyl)sulfane ≥97%
Supplier:
AOB CHEM USA
Description:
(2,3-difluoro-4-iodophenyl)(methyl)sulfane ≥97%
Supplier:
Spectrum Chemicals
Description:
TYROSINE, USP is one of 22 acids that are used by cells in order to synthesize proteins. It is a non essential amino acid that has a polar side group. It is an important part of photosynthesis as it acts as an electron donor in the reduction of oxidized chlorophyll. Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
Supplier:
AMBEED, INC
Description:
4-Iodophenylhydrazine hydrochloride 97%
Supplier:
Matrix Scientific
Description:
MF=C8H6In MW=243.05 Cas=130723-54-5 MDL=MFCD00040890 5G
Supplier:
AMBEED, INC
Description:
3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione, Purity: 97%, CAS Number: 871700-22-0, Appearance: Light yellow to yellow powder or crystals, Storage: Keep in dark place, Sealed in dry, 2-8 C, Size: 1g
Supplier:
Adipogen
Description:
Potent and subtype-selective (<gt/>1'000-fold) PPARgamma agonist. Angiogenesis inhibitor. Apoptosis inhibitor. Anti-inflammatory. Anti-hyperglycemic and anti-hyperlipidemic agent. Antidiabetic. The glucose-lowering effect in rats is 100-fold more potent than that of troglitazone.
Catalog Number:
(10300-200)
Supplier:
Bioss
Description:
G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097).
Catalog Number:
(101925-996)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 063579-500MG , MDL Number: MFCD00227471
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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