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4-Methyl-3,4-dihydroquinoxalin-2(1H)-one
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4-Methyl-3,4-dihydroquinoxalin-2(1H)-one
Catalog Number:
(10071-214)
Supplier:
Prosci
Description:
FUNCTION: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Catalog Number:
(10068-516)
Supplier:
Prosci
Description:
Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gammadependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion
Catalog Number:
(10070-904)
Supplier:
Prosci
Description:
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
Catalog Number:
(MSPP-CEK623GE)
Supplier:
CLOUD-CLONE CORP MS
Description:
This assay has high sensitivity and excellent specificity for detecting General species LPA (Lysophosphatidic Acid). The assay range is from 123.5 to 10000 ng/ml (Competitive kit) with a sensitivity of 50.5 ng/ml. There is no detectable cross-reactivity with other relevant proteins. Activity loss rate and accelerated stability test ect have been conducted to guarantee the best performance of the products after long storage and delivery.
Catalog Number:
(10070-436)
Supplier:
Prosci
Description:
An antiphosphotyrosine antibody was used to identify proteins that are phosphorylated in Rous sarcoma virus-transformed chick embryo fibroblasts, and a 76-kD protein was obtained that localizes to focal adhesions at the ends of actin-containing stress fibers in nontransformed cells. This protein was purified from chicken gizzard smooth muscle, and was named Pxn (Paxillin) ('paxillus' means 'small stake' or 'peg' in Latin) as a protein tethered to the membrane at focal adhesions
Catalog Number:
(10070-050)
Supplier:
Prosci
Description:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition.
Catalog Number:
(10068-670)
Supplier:
Prosci
Description:
Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
Catalog Number:
(MSPP-CEA577GE)
Supplier:
CLOUD-CLONE CORP MS
Description:
This assay has high sensitivity and excellent specificity for detecting General species cGMP (Cyclic Guanosine Monophosphate). The assay range is from 123.5 to 10000 pg/ml (Competitive kit) with a sensitivity of 49.4 pg/ml. There is no detectable cross-reactivity with other relevant proteins. Activity loss rate and accelerated stability test ect have been conducted to guarantee the best performance of the products after long storage and delivery.
Catalog Number:
(10068-948)
Supplier:
Prosci
Description:
May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Catalog Number:
(76735-256)
Supplier:
ANTIBODIES.COM LLC
Description:
Rat PFKM ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of rat PFKM in serum, plasma, tissue homogenates, and other biological fluids.
Supplier:
Biotium
Description:
PLAP (Placental Alkaline Phosphatase), Monoclonal antibody, Clone: ALPP/238, Host: Mouse, Species reactivity: Human, Isotype: IgM, kappa, Conjugate: CF405S, Immunogen: Recombinant full-length human ALPP protein, Application: IF, Immunohistology (formalin), Flow, Size: 100uL
Catalog Number:
(MSPP-CEG409GE)
Supplier:
CLOUD-CLONE CORP MS
Description:
This assay has high sensitivity and excellent specificity for detecting General species NAD (Nicotinamide Adenine Dinucleotide). The assay range is from 123.5 to 10000 ng/ml (Competitive kit) with a sensitivity of 49.3 ng/ml. There is no detectable cross-reactivity with other relevant proteins. Activity loss rate and accelerated stability test ect have been conducted to guarantee the best performance of the products after long storage and delivery.
Catalog Number:
(10071-126)
Supplier:
Prosci
Description:
FUNCTION: Appears to function in modulating the activity of the immune system during the acute-phase reaction.
SIMILARITY: Belongs to the lipocalin family. SUBCELLULAR LOCATION: Secreted protein. TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma. INDUCTION: Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation. POLYMORPHISM: Three common alleles of ORM1 are known. ORM1*F1 has Gln-38/Val-174; ORM1*F2 has Gln-38/Met-174 and ORM1*S has Arg-38/Val-174.
Catalog Number:
(10068-780)
Supplier:
Prosci
Description:
Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.
Catalog Number:
(10070-268)
Supplier:
Prosci
Description:
Smad3 encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.
Catalog Number:
(77201-560)
Supplier:
ANTIBODIES.COM LLC
Description:
Human CRISP2 ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i><i>in vitro</i></i> quantitative determination of human CRISP2 in serum, plasma, and other biological fluids.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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