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4\'-(Trifluoromethyl)biphenyl-3-carboxylic+acid
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4\'-(Trifluoromethyl)biphenyl-3-carboxylic+acid
Catalog Number:
(102837-282)
Supplier:
Matrix Scientific
Description:
6-[(3-Trifluoromethyl)phenyl]pyridine-2-carboxylic acid ≥97%
Supplier:
AMBEED, INC
Description:
6-(Trifluoromethyl)-1H-indazole-3-carboxylic acid, Purity: 98%, CAS Number: 887576-98-9, Appearance: Solid, Storage: Sealed in dry, 2-8C, Size: 100MG
Supplier:
AMBEED, INC
Description:
2-(Trifluoromethyl)pyrimidine-5-carboxylic acid, Purity: 97%, CAS Number: 306960-77-0, Appearance: Form: solid, Storage: Sealed in dry, Room Temperature, Size: 10g
Supplier:
AMBEED, INC
Description:
8-Methoxy-2-(trifluoromethyl)quinoline-5-carboxylic acid, Purity: 95%, CAS number: 199872-29-2, Appearance: Solid, Storage: Sealed in dry, Room Temperature, Size: 100MG
Supplier:
Matrix Scientific
Description:
MF=C11H6F3NO2 MW=241.17 CAS=588702-67-4 MDL=MFCD06796588 5G
Catalog Number:
(76973-512)
Supplier:
AMBEED, INC
Description:
3-(Trifluoromethyl)quinoline-4-carboxylic acid, Purity: 95%, CAS number: 588702-65-2, Appearance: White to yellow powder or crystals, Storage: Sealed in dry, Room Temperature, Size: 250MG
Supplier:
ALADDIN SCIENTIFIC
Description:
Product DescriptionDGAT-1 inhibitor A 922500 (A-922500) reduces serum triglyceride levels from baseline at all doses tested; however, this is only statistically significant at the 3 mg/kg dose, which lowers serum triglycerides by 53%. Similarly, the 3 mg/kg dose of A 922500 significantly reduces serum FFA concentrations by 55% and total cholesterol by 25%. DGAT-1 inhibition has no significant effect on body weight at any dose tested. Although A 922500 dpes not significantly affect LDL-cholesterol or HDL-cholesterol individually, the serum LDL/HDL-cholesterol ratio is significantly improved by A 922500 at 0.3 and 3 mg/kg. Similar to the dyslipidemic hamster, treatment with 3 mg/kg A 922500 significantly reduces serum triglyceride concentrations (39%). FFA levels significantly increase over the 14-day period in vehicle-treated animals. This increase is inhibited in a dose-dependent manner by A 922500 such that FFA concentrations are 32% lower after 14 days of treatment with the DGAT-1 inhibitor at 3 mg/kg, compared with the vehicle group (p < 0.05). HDL-cholesterol is significantly increased from baseline levels by A 922500 at 0.3 and 3 mg/kg; however, this is only significantly increased compared with vehicle at the 3 mg/kg dose. Body weight significantly increases over the 2-week period in vehicle-treated rats, and this is not affected by A 922500. LDL-cholesterol is significantly reduced in the vehicle treated group. DGAT-1 inhibition does not further reduce LDL-cholesterol and has no effect on total cholesterol.Product ApplicationA922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages.
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 044606-5G , MDL Number: MFCD03012933
Supplier:
Thermo Scientific Chemicals
Description:
5g CAS: 306960-77-0, MDL: MFCD09054851
Catalog Number:
(102837-992)
Supplier:
Matrix Scientific
Description:
1-[4-(Trifluoromethyl)benzyl]piperidine-4-carboxylic acid ≥97%
Catalog Number:
(102838-192)
Supplier:
Matrix Scientific
Description:
1-[3-(Trifluoromethyl)benzyl]pyrrolidine-3-carboxylic acid ≥97%
Catalog Number:
(102837-334)
Supplier:
Matrix Scientific
Description:
4-[(4-Trifluoromethyl)phenyl]pyridine-2-carboxylic acid ≥97%
Catalog Number:
(102837-336)
Supplier:
Matrix Scientific
Description:
4-[(3-Trifluoromethyl)phenyl]pyridine-2-carboxylic acid ≥97%
Catalog Number:
(102838-172)
Supplier:
Matrix Scientific
Description:
1-[4-(Trifluoromethyl)phenyl]pyrrolidine-3-carboxylic acid ≥97%
Supplier:
AMBEED, INC
Description:
2-Methyl-4-(trifluoromethyl)thiazole-5-carboxylic acid 95%
Supplier:
Matrix Scientific
Description:
1-[4-(Trifluoromethyl)pyrimidin-2-yl]piperidine-4-carboxylic acid ≥97%
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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