4-(1H-Tetrazol-5-yl)benzoic+acid
Catalog Number:
(102536-274)
Supplier:
Matrix Scientific
Description:
MF=C9H15NO2 MW=169.23 CAS=80828-13-3 MDL=MFCD00171406 5G
Supplier:
Matrix Scientific
Description:
1-(N,N-Dimethylglycyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid
Supplier:
Adipogen
Description:
AMG-458 is a potent inhibitor of c-Met with an IC(50) of 60nM and displays selectivity against VEGFR2.
Supplier:
Matrix Scientific
Description:
MF=C9H5F3N2O2 MW=230.15 Cas=2107-39-3 5G
Supplier:
AMBEED, INC
Description:
1H-Indazole-5-carboxylic acid, Purity: 97%, CAS Number: 61700-61-6, Appearance: White to Pale-yellow Powder or Crystals, Storage: Keep in dark place, Sealed in dry, Room Temperature, Size: 1G
Supplier:
AOB CHEM USA
Description:
1,7-Dimethyl-1H-indazole-5-boronic acid ≥97%
Supplier:
Matrix Scientific
Description:
1-(4-Chlorophenyl)-5-propyl-1H-pyrazole-4-carboxylic acid ≥97%
Catalog Number:
(MK235757)
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
For Laboratory,Research,or Manufacturing Use
Supplier:
Adipogen
Description:
Antagonizing the Chk1-mediated cell cycle checkpoints has emerged as an attractive target for anticancer therapy. If Chk1 activity is blocked, DNA-damaged or spindle-disrupted cells would exit cell cycle arrest before full repair and subsequently undergo mitotic catastrophe or cell death. Chk1 inhibitors consequently increase the therapeutic index of DNA-damaging or antimitotic agents as well. PF-0477736 is a selective, potent ATP-competitive Chk1 inhibitor, derived from PF-0394691, inhibits Chk1 (Ki, 0.49nM) and Chk2 (Ki, 47nM) in vitro. In tests, PF-0477736 was identified as a potent, selective ATP-competitive small-molecule inhibitor that inhibits Chk1 with a Ki of 0.49nM. PF-0477736 abrogates cell cycle arrest induced by DNA damage and enhances cytotoxicity of clinically important chemotherapeutic agents, including gemcitabine and carboplatin. In xenografts, PF-0477736 enhanced the antitumor activity of gemcitabine in a dose-dependent manner. PF-0477736 combinations were well tolerated with no exacerbation of side effects commonly associated with cytotoxic agents.
Supplier:
AMBEED, INC
Description:
6-Bromo-1H-indazole-3-carboxylic acid, Purity: 97%, CAS Number: 660823-36-9, Appearance: White to Yellow to Brown Solid, Storage: Sealed in dry, 2-8 C, Size: 1g
Supplier:
AMBEED, INC
Description:
3-Methyl-1H-indazole-6-boronic Acid, Purity: 95%, CAS number: 1245816-26-5, Appearance: Off white to Pale-yellow to Yellow-brown Solid, Storage: Sealed in dry, 2-8C, Size: 5G
Catalog Number:
(102837-782)
Supplier:
Matrix Scientific
Description:
1-Methyl-2-propyl-1H-imidazole-4,5-dicarboxylic acid ≥97%
Supplier:
AMBEED, INC
Description:
3-Bromo-1H-pyrazole-5-carboxylic acid, Purity: 95%, CAS Number: 1905484-46-9, Appearance: Solid, Storage: Inert atmosphere, 2-8C, Size: 5G
Supplier:
AMBEED, INC
Description:
4-(3-Chlorophenyl)-1H-pyrrole-2-carboxylic acid, Purity: 95%, CAS Number: 1511974-79-0, Appearance: Solid, Storage: Sealed in dry, 2-8C, Size: 1G
Supplier:
AMBEED, INC
Description:
5,6-Dimethoxy-1H-indole-2-carboxylic acid, Purity: 95%, CAS Number: 88210-96-2, Appearance: Solid, Storage: Sealed in dry, Room Temperature, Size: 5G
Supplier:
Matrix Scientific
Description:
1-(4-Bromo-3-Methylphenyl)-5-Methyl-1H-1, 2, 3-Triazole-4-Carboxylic Acid, MF=C11H10BRN3O2, MW=296.13, CAS=933242-93-4, 500MG
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