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4-(1H-Tetrazol-5-yl)benzoic+acid
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4-(1H-Tetrazol-5-yl)benzoic+acid
Catalog Number:
(10409-170)
Supplier:
Bioss
Description:
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect machanism. Interacts with CRY1 and CRY2; negatively regulates CRY1 phosphorylation.
Supplier:
Enzo Life Sciences
Description:
Spin trapping reagent.
Catalog Number:
(10336-968)
Supplier:
Bioss
Description:
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes.
Catalog Number:
(PI20408)
Supplier:
Invitrogen
Description:
Thermo Scientific Pierce 2-Mercaptoethylamine-HCl, commonly abbreviated 2-MEA, is a mild reductant that is often used to selectively reduce hinge-region disulfide bonds in antibody.
Supplier:
Bachem Americas
Description:
5G CAS: 40719-58-2 C8H17N3O3 · HCl FW: 239.7
Supplier:
MilliporeSigma
Description:
(Cys, HCI). White solid. Purity: >98% by titration. Soluble in H2O. RTECS HA2275000, CAS 52-89-1, M.W. 157.6. WARNING! May cause irritation.
Catalog Number:
(BJ35009-1L)
Supplier:
Honeywell Research Chemicals
Description:
Hydrogen chloride 2-propanol solution, Grade: Analytical, MF: HCl, Molar mass: 36.46 g/mol, Appearance: Liquid, Synonyms: Hydrochloric acid in 2-propanol, 0.1 M HCl in 2-propanol (0.1N), for Total Base Number, according to DIN 51558-1, Volumetric, Size: 1L
Supplier:
AMBEED, INC
Description:
2,3,4,6-Tetrachloropyridine 97%
Supplier:
AMBEED, INC
Description:
2,4,6-Trichloropyrimidine 98%
Catalog Number:
(103375-122)
Supplier:
Biosynth International Inc
Description:
Ropivacaine HCL, Purity: 98.0% HPLC, CAS Number: 98717-15-8, Molecular Formula: C17H26N2O.HCL, Molecular weight: 310.86 g/mol, Color: white to off-white, Form: powder, Storage: 5 deg C, close container well, keep dry, size: 250G
Catalog Number:
(100271-454)
Supplier:
Indofine Chemical Company
Description:
Rare Organics & BioChemicals 53956-05-1 1gm H-2-Abu-OtBu. HCI 195.7 Room temperature.
Supplier:
BeanTown Chemical
Description:
CAS: 7647-01-0; EC No: 231-595-7; MDL No: MFCD00011324; RTECS: MW4025000
UN No: UN1789; Haz Class: 8; Packing Group: II
Liquid, single sub-boiling quartz distillation; Molecular Formula: HCl; MW: 36.46
Boiling Point: <gt/>100°
Density (g/mL): 1.19
Catalog Number:
(10663-462)
Supplier:
Bioss
Description:
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.
Supplier:
AMBEED, INC
Description:
3-Fluoropiperidine hydrochloride 98%
Catalog Number:
(PI26103)
Supplier:
Invitrogen
Description:
Thermo Scientific Pierce Hydroxylamine-HCl has many uses, which include cleaving Asn-Gly peptide bonds and deprotecting (exposing) sulfhydryls on SATA-modified molecules for conjugation.
Supplier:
TCI America
Description:
Dibenzyl L-Glutamate Hydrochloride, Purity: >98.0%(HPLC)(T), CAS Number: 4561-10-8, Molecular Formula: C19H21NO4.HCl, Molecular Weight: 363.84, Synonyms: L-Glutamic Acid Dibenzyl Ester Hydrochloride, H-Glu(OBzl)-OBzl.HCI, Size: 5G
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