[Ir(ppy)2([2,2\\\'-bipyridine]-4-carboxylic acid)]Cl
Catalog Number:
(10461-972)
Supplier:
Bioss
Description:
G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.
Catalog Number:
(TCA0158-5G)
Supplier:
TCI America
Description:
CAS Number: 61-19-8
MDL Number: MFCD00005750 Molecular Formula: C10H14N5O7P Molecular Weight: 347.22 Purity/Analysis Method: >98.0% (HPLC,T) Form: Crystal Melting point (°C): 200
Catalog Number:
(103222-668)
Supplier:
Novus Biologicals
Description:
C2CD3 Antibody, Polyclonal, Host: Sheep, Species: Human, Isotype: IgG, Immunogen: E. Coli-derived recombinant human C2CD3 Met1-Asp109, Synonyms: C2 calcium-dependent domain containing 3, Applications: ICC, Size: 100UG
Catalog Number:
(89267-404)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to ISYNA1 (N-terminal)
Catalog Number:
(76101-704)
Supplier:
Bioss
Description:
SM22 alpha is an actin cross-linking/gelling protein that belongs to the calponin family. It is involved in calcium interactions and contractile properties of the cell. SM22 may contribute to replicative senescence.
Catalog Number:
(10393-924)
Supplier:
Bioss
Description:
In the presence of inorganic orthophosphate, the platelet-derived endothelial growth factor (PD-ECGF) thymidine phosphorylase (TP) (gliostatin) catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites.
Supplier:
BeanTown Chemical
Description:
CAS: 15578-26-4; EC No: 239-635-5; MDL No: MFCD00049544
Powder; Linear Formula: Sn2P2O7; MW: 411.32
Melting Point: 400° (decomposes)
Density (g/mL): 4.009
Catalog Number:
(75793-644)
Supplier:
Prosci
Description:
Microfibril-associated protein 4 (MFAP4) was initially identified as a gene commonly deleted in the contiguous Smith-Magenis syndrome (SMS) gene. MFAP4 was identified as growth factor to support expansion of hematopoietic stem cells in culture. It is involved in calcium-dependent cell adhesion and intercellular interactions.
Supplier:
Innovative Research Inc
Description:
Protein C Monoclonal antibody, Clone: 5071, Host: Mouse, Species: Human, Isotype: IgG1, Recognizes human protein C, activated protein C, Partial calcium dependence, Application: ELISA, Affinity Purification, Radioimmunoassay, WB, Storage: -20 deg C, Size: 0.5mg
Catalog Number:
(10391-990)
Supplier:
Bioss
Description:
SLC37A4 transports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum. It forms a complex with glucose-6-phosphatase which is responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.
Catalog Number:
(77437-112)
Supplier:
Bioss
Description:
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
Catalog Number:
(10298-822)
Supplier:
Bioss
Description:
This gene encodes the gamma sunbunit of the N-acetylglucosamine-1-phosphotransferase complex. This hexameric complex, composed of alpha, beta and gamma subunits, catalyzes the first step in synthesis of a mannose 6-phosphate lysosomal recognition marker. This enzyme complex is necessary for targeting of lysosomal hydrolases to the lysosome. Mutations in the gene encoding the gamma subunit have been associated with mucolipidosis IIIC, also known as mucolipidosis III gamma.[provided by RefSeq, Feb 2010].
Catalog Number:
(10452-388)
Supplier:
Bioss
Description:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.
Catalog Number:
(10409-894)
Supplier:
Bioss
Description:
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
Catalog Number:
(10413-196)
Supplier:
Bioss
Description:
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
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