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3,5-Difluoro-2-hydroxybenzonitrile
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3,5-Difluoro-2-hydroxybenzonitrile
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 052566-500MG , MDL Number: MFCD13562300
Catalog Number:
(77877-253)
Supplier:
AMBEED, INC
Description:
Bis-TRIS hydrochloride 97%
Catalog Number:
(102996-110)
Supplier:
Anaspec Inc
Description:
Gastrin-1 is also referred to as Gastrin-17 or “Little Gastrin.” Secretion of gastrin is induced by food intake and causes the release of gastric acid in the stomach. Secreted by the G cells in the gastric mucosa, it is one of the major bioactive forms of gastrin found in tissue and plasma (the other bioactive form is Gastrin-34 or Big Gastrin - Cat# AS-20747). Both Gastrin-17 and Gastrin-34 are carboxy-amidated and partially tyrosine sulfated. Binding of Gastrin to the CCK2/gastrin receptor requires carboxy-amidation, however sulfation is not necessary for binding to the receptor. Binding of Gastrin to the CCK2/Gastrin receptors on parietal cells of the stomach causes them to secrete hydrochloric acid (HCl) and stimulates lectin-like protein Reg expression via activation of PKC and RhoA. Gastrin also plays a role in release of Histamine and Pepsinogen.
Sequence: Pyr-GPWLEEEEEAYGWMDF-NH2 MW: 2098.2 Da % Peak area by HPLC: 95 Storage condition: -20° C
Catalog Number:
(77439-676)
Supplier:
Bioss
Description:
Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as G alpha-q, G alpha-11, G alpha-14, G alpha-12 and G alpha-13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to G alpha-q/11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of G alpha-q/11 and involves promotion of cofilin dephosphoryltaion and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders.
Catalog Number:
(TCA1367-1G)
Supplier:
TCI America
Description:
CAS Number: 15959-93-0
MDL Number: MFCD00671488 Molecular Formula: C4H6F3NO2 Molecular Weight: 193.55 Purity/Analysis Method: >98.0% (T) Form: Crystal
Supplier:
Adipogen
Description:
TMBZ is a chromogenic reagent utilized for peroxidase detection. It has been developed as an alternative to benzidine. Although the TMBZ solution is colorless, it turns bluish-green (lambdamax: 655 nm) in the presence of hydrogen peroxide and peroxidase. The structure of this bluish-green complex is thought to be a radical form of two oxidized TMBZ molecules. This peroxidase substrate is used in staining procedures in immunohistochemistry as well as being a visualising reagent used in enzyme-linked immunosorbent assays (ELISA). The substrate produces a soluble end product that is pale blue in color and can be read spectrophotometrically at 370 or 620-650 nm. The TMB reaction may be stopped with 2M H2SO4 (resulting in a yellow color), and read at 450nm.
Catalog Number:
(PAZ3781)
Supplier:
Promega Corporation
Description:
This antibody [subclass IgG(2a)(kappa)] recognizes E. coli beta-galactosidase.
Catalog Number:
(PAG4521)
Supplier:
Promega Corporation
Description:
Sixteen DNA fragments ranging from 50bp to 800bp in 50bp increments plus an 1,800bp "backbone" fragment.
Catalog Number:
(80055-146)
Supplier:
MilliporeSigma
Description:
Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50=17uM). Acts as peripheral vasodilator. Inhibitor of lysosomal sphingomyelinase. CAS: 69-09-0. FW: 355.3. Purity: >=99% by titration. Soluble in methanol, ethanol and water. 500mg white solid.
Catalog Number:
(76287-322)
Supplier:
First Aid Only
Description:
Tablets temporarily relieve nasal congestion due to the common cold, hay fever, or other upper respiratory allergies.
Supplier:
Spectrum Chemicals
Description:
Potassium Hydrogen Phthalate, Acidimetric Standard, Crystal, Reagent Special, ACS is used in analytical chemistry as a disintegrating agent can be used as a buffering agent (in combination with hydrochloric acid (HCl) or sodium hydroxide (NaOH). As an ACS grade Reagent, Spectrum Chemical manufactured Potassium Hydrogen Sulfate is used as the quality standard against which other Potassium Hydrogen Sulfate substances are graded. it has met the toughest regulatory standards for quality and pureness
Supplier:
G-Biosciences
Description:
G-Biosciences offers various sized supplies of the following hybridization buffers: Church & Gilbert’s [2X], Denhardt Solution [100X], Hybridization Denaturing Solution, Hybridization Neutralizing Solution, SSC [20X], SSPE [20X], TMAC Hyb Solution [3X], and TNT Buffer.
Supplier:
Biosynth International Inc
Description:
5-Aminolevulinic acid hydrochloride is a δ-amino acid and be used as bronsted acid.
Catalog Number:
(89160-362)
Supplier:
Enzo Life Sciences
Description:
NAD+ (SIRT Substrate)
Catalog Number:
(TCM1985-1G)
Supplier:
TCI America
Description:
CAS Number: 61367-16-6
MDL Number: MFCD08274537 Molecular Formula: C8H15NO2 Molecular Weight: 193.67 Purity/Analysis Method: >98.0% (N,T) Form: Crystal Melting point (°C): 188
Supplier:
ALADDIN SCIENTIFIC
Description:
Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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