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4,4\'-Methylenebis(2,6-diethylaniline)
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4,4\'-Methylenebis(2,6-diethylaniline)
Catalog Number:
(10068-812)
Supplier:
Prosci
Description:
Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3, 4, 5-trisphosphate, phosphatidylinositol 3, 4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1, 3, 4, 5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3, 4, 5)P3 > PtdIns(3, 4)P2 > PtdIns3P > Ins(1, 3, 4, 5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue.
Supplier:
BeanTown Chemical
Description:
CAS: 61676-62-8; MDL No: MFCD00192241
UN No: UN1993; Haz Class: 3; Packing Group: III
Liquid; Molecular Formula: C9H19BO3; MW: 186.06
Boiling Point: 73°/15 mmHg; Flash point: 43°C (109°F)
Density (g/mL): 0.912; Refractive Index: 1.409
Moisture Sensitive
Supplier:
Biolegend
Description:
CD4 Monoclonal Antibody, Clone: GK1.5, Host: Rat, Species reactivity: Mouse, Isotype: Rat IgG2b, K, Conjugate: Spark NIR 685, Immunogen: CTL clone V4, Formulation: Phosphate-buffered solution, pH 7.2, Synonyms: L3T4, T4, Storage: between 2 deg C and 8 deg C, Application: FC, Size: 25ug
Catalog Number:
(76422-444)
Supplier:
Biolegend
Description:
CD154, Recombinant Monoclonal Antibody, Clone: QA17A53, Host: Rat, Species Reactivity: Mouse, Isotype: IgG1, K, Conjugate: PE, Other Names: CD40 ligand (CD40L), gp39, T-BAM, TRAP, Ly-62, TNFSF5, Formulation: Phosphate-buffered solution, pH 7.2, 0.09% sodium azide, Size: 25 uG
Supplier:
Biolegend
Description:
CD5 Monoclonal Antibody, Clone: 53-7.3, Host: Rat, Species reactivity: Mouse, Isotype: IgG2a, K, Conjugate: PE/Dazzle 594, Immunogen: Mouse thymus, Formulation: Phosphate-buffered solution, pH 7.2, 0.09% sodium azide, Synonyms: Lyt-1, Ly-1, Storage: between 2 deg C and 8 deg C, Size: 100ug
Supplier:
BeanTown Chemical
Description:
CAS: 2176-62-7; EC No: 218-535-5; MDL No: MFCD00006230; RTECS: UT7000000
UN No: UN3077; Haz Class: 9; Packing Group: III
Powder; Molecular Formula: C5Cl5N; MW: 251.33
Melting Point: 123-127°
Supplier:
BeanTown Chemical
Description:
CAS: 8007-47-4; EC No: 232-362-2; MDL No: MFCD00132800; RTECS: CP2352500
UN No: UN1993; Haz Class: 3; Packing Group: III
Liquid
Flash point: 62°C (144°F)
Density (g/mL): 0.99; Refractive Index: 1.522
Supplier:
Southern Biotechnology
Description:
The lymphocyte Fcγ receptors recognize the Fc portion of IgG, presented either as immune complexes or as free antibody. The different classes of receptors are distinct because of varying size, tissue distribution and affinity for IgGs. The Fc type II receptor is expressed on a wide variety of cells including B cells, hematopoietic cells, monocyte/macrophages, neutrophils, platelets, Langerhans cells, eosinophils, basophils, trophoblasts, and endothelial cells of the placenta. The Fcγ type III receptors are higher affinity than the type II and are expressed on macrophages, NK cells and neutrophils. Both types of receptors can be expressed on the same cell and in varying ratios. The receptors are constitutively expressed, although cytokines and lymphokines can modulate their expression. Besides identifying FcγR+ cells, monoclonal antibodies to the FcγII/III receptor have been used to block Fc receptor binding of IgG, Fc-mediated signal transduction and effector functions, clearance of immune complexes and to attenuate infection by organisms dependent on FcγR for parasitic invasion. The monoclonal antibody 93 recognizes a conformational epitope formed by FcγII and FcγIII receptors.
Supplier:
BeanTown Chemical
Description:
CAS: 7440-05-3; EC No: 231-115-6; MDL No: MFCD00011167
UN No: UN1325; Haz Class: 4.1; Packing Group: III
Powder; Molecular Formula: Pd; MW: 106.42
Melting Point: 1555°; Boiling Point: 2963°
Supplier:
BeanTown Chemical
Description:
CAS: 95-54-5; EC No: 202-430-6; MDL No: MFCD00007721; RTECS: SS7875000
UN No: UN1673; Haz Class: 6.1; Packing Group: III
Solid; Linear Formula: C6H4(NH2)2; Molecular Formula: C6H8N2; MW: 108.14
Melting Point: 98-102°; Boiling Point: 256-258°; Flash point: 136°C (277°F)
Density (g/mL): 1.03
Moisture Sensitive
Catalog Number:
(76422-760)
Supplier:
Biolegend
Description:
CD8a Monoclonal Antibody, Clone: 53-6.7, Host: Rat, Species: Mouse, Isotype: IgG2a, K, Conjugate: TotalSeq C0002, Immunogen: Mouse thymus, Formulation: Phosphate-buffered soln, pH 7.2, 0.09% sodium azide, Synonyms: T8, Lyt2, Storage: between 2 deg C and 8 deg C, Application: FC, Size: 10 ug
Catalog Number:
(10282-026)
Supplier:
Bioss
Description:
The alcohol dehydrogenase family of proteins metabolize a wide variety of substrates, including retinol, hydroxysteroids, ethanol, aliphatic alcohols and lipid peroxidation products. ADH5 (alcohol dehydrogenase 5 (class III)), also known as FDH (formaldehyde dehydrogenase), ADHX, ADH-3 or GSNOR, is a 374 amino acid cytoplasmic protein that belongs to the class III subfamily of alcohol dehydrogenases. Expressed ubiquitously, ADH5 uses iron as a cofactor to catalytically oxidize both long-chain primary alcohols and S-hydroxymethyl-glutathione, a product formed spontaneously between formaldehyde and glutathione. ADH5 exists as a homodimer and, via its ability to oxidize S-hydroxymethyl-glutathione and, thus, eliminate formaldehyde, functions as an important component of cellular metabolism. Genetic variations in the gene encoding ADH5 may affect drug and alcohol dependence in humans.
Supplier:
BeanTown Chemical
Description:
CAS: 14165-55-0; EC No: 238-007-8; MDL No: MFCD00015121
UN No: UN1993; Haz Class: 3; Packing Group: III
Liquid; Linear Formula: Ge(OCH2CH3)4; Molecular Formula: C8H20GeO4 ; MW: 252.84
Flash point: 48°C (118°F)
Density (g/mL): 1.14 ; Refractive Index: 1.407
Moisture Sensitive
Catalog Number:
(10254-418)
Supplier:
Bioss
Description:
The inositol polyphosphate 5-phosphatases selectively remove the phosphate from the 5-position of various phosphatidylinositols, which generate second messengers in response to extracellular signals. Synaptojanins are characterized by an N-terminal SAC1-like sequence, a central 5-phosphate domain, and a unique C-terminal sequence and have been shown to use phosphatidylinositol 4,5-bisphosphate as a substrate. Synaptojanins exist as two isoforms, synaptojanin 1 and 2, which differ in the C-terminal domain, and each isoform has multiple variants produced by alternative splicing. Synaptojanin 1 is expressed as two major forms: the shorter is found in brain while the longer is expressed in peripheral tissues. Eight splice variants of synaptojanin 2 have been detected, including a brain specific isoform. Synaptojanins are thought to participate in the endocytosis of synaptic vesicles and the regulation of the actin cytoskeleton.
Supplier:
BeanTown Chemical
Description:
CAS: 128-37-0; EC No: 204-881-4; MDL No: MFCD00011644; RTECS: GO7875000
UN No: UN3077; Haz Class: 9; Packing Group: III
Crystalline/Powder; Molecular Formula: C15H24O; MW: 220.35
Melting Point: 69-73°; Boiling Point: 265°; Flash point: 127°C (260°F)
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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