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4-(Piperidin-4-yl)phenol+hydrobromide
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4-(Piperidin-4-yl)phenol+hydrobromide
Supplier:
Adipogen
Description:
AT7519 is a potent inhibitor of several CDK family members. AT7519 showed potent antiproliferative activity (40-940nM) in a panel of human tumor cell lines, and the mechanism of action was shown here to be consistent with the inhibition of CDK1 and CDK2 in solid tumor cell lines. AT7519 caused cell cycle arrest followed by apoptosis in human tumor cells and inhibited tumor growth in human tumor xenograft models. Tumor regression was observed following twice daily dosing of AT7519 in the HCT116 and HT29 colon cancer xenograft models. Also it has been shown that the biological effects are linked to inhibition of CDKs in vivo and that AT7519 induces tumor cell apoptosis in these xenograft models. Moreover, AT7519 has an attractive biological profile and is well tolerated and effective making it a more plausible candidate for clinical development than previously available CDK inhibitors. In in vitro kinase assays AT7519 showed nanomolar levels of activity from <lt/>10 to 2400 for cyclins; only one other non-cyclin related kinase was inhibited at levels below 10µM (GSK3beta, 89nM), all others tested had IC(50)'s of greater than 10,000nM.
Catalog Number:
(101919-618)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 060207-500MG , MDL Number: MFCD19442224
Catalog Number:
(EM-HX0600-3)
Catalog Number:
(102092-212)
Supplier:
Electron Microscopy Sciences
Description:
A/ Poly-L-Lysine Hydrobromide 30,000-70,000 is a polycation, which binds to DNA, red cell membranes and any negatively, charged proteins. It is useful for promoting cell adhesion; for the preparation of polycationic beads, useful in immobilization techniques; immobilization of membranes; immobilization of plant protoplasts. In cell culture, immobilization by micro encapsulation with the alginate-poly-L-lysine microcapsule system. It is available in a prepared 0.1% aqueous solution, micro-filtered, which is ideal for cell culture growth.
Catalog Number:
(76204-134)
Supplier:
MP Biomedicals
Description:
Poly-L-lysine is a positively charged amino acid polymer. Poly-lysine binds to DNA, red cell membrane and any negatively charged protein. It is typically used as a coating substrate for culture dishes, slides, etc. It enhances electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. When adsorbed to the culture surface, poly-lysine increases the number of positively charged sites available for cell binding.
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Pyridinium tribromide 90+%, Technical Grade
Catalog Number:
(EM8.14371.0010)
Supplier:
MilliporeSigma
Description:
Triethylamine trishydrofluoride for synthesis, CAS number 73602-61-6, Chemical formula (C2H5)3N * 3 HF
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 059667-1G , MDL Number: MFCD18803537
Supplier:
Thermo Scientific Chemicals
Description:
Fieser: 1,967 5,568 6,499 9,399 10,333 15,276
Supplier:
MP Biomedicals
Description:
Poly-L-Lysine is typically used as a coating substrate for culture dishes, slides, etc.
Supplier:
MP Biomedicals
Description:
There is approximately one HBr or HCl per lysine unit. The HBr/HCl allows it to be a crystalline solid and soluble in water. To remove the HBr/HCl, solubilize the product in a neutral buffer and dialyze away the salts.
Supplier:
VWR International
Description:
VWR® Black Phenolic Caps provide a wide range of chemical compatibility and temperature tolerance with an assortment of liners to choose from.
Supplier:
VWR International
Description:
Phenolic resin worksurfaces are composed of cellulose fiber-reinforced, phenolic resin core with a highly crosslinked, polyurethane, copolymer surface.
Catalog Number:
(76204-002)
Supplier:
MP Biomedicals
Description:
Poly-L-lysine is a positively charged amino acid polymer. Poly-lysine binds to DNA, red cell membrane and any negatively charged protein. It is typically used as a coating substrate for culture dishes, slides, etc. It enhances electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. When adsorbed to the culture surface, poly-lysine increases the number of positively charged sites available for cell binding.
Catalog Number:
(97064-716)
Supplier:
VWR
Description:
For RNA purification, it is best to use a phenol or phenol:chloroform mixture with a pH of 4.5 to 5.5. Although phenol alone will purify RNA in these extractions, messenger RNA can collect with the DNA at the inter-phase in the complete absence of chloroform. The ratio of phenol to chloroform can vary from no chloroform to a 1:1 mixture, depending on the individual tissue and the character of the RNA being purified. For many applications, a 5:1 ratio of phenol:chloroform is a recommended starting point. The phenol used for extraction protocols must be highly purified and essentially free of contamination by phenolic acid, a product of phenol oxidation. VWR’s phenol products are manufactured from the purest crystalline phenol to ensure optimal results.
Catalog Number:
(101823-370)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 027037-500MG , MDL Number: MFCD13176564
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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