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Description:
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL18 / IL-18 / Interleukin 18 (rh IL18 / IL-18 / Interleukin 18; Catalog#10119-H09E; Q14116; Met1-Asp193). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Description:
The Recombinant Mouse IL-18/IL-1F4 Protein from R&D Systems is derived from E. coli. The Recombinant Mouse IL-18/IL-1F4 Protein has been validated for the following applications: Bioactivity.
Description:
Interleukin 18 binding protein (IL-18BP) is a physiological inhibitor that acts through binding to the receptor-binding site of IL-18. IL-18 stimulates INF- gamma , which then stimulates 18BP production via NF-κB. The interaction between IL-18 and IL-18BP has a significant role in the inflammation process. IL-18 BPs have four isoforms, a, b, c and d, which are spliced by different ways. The IL-18 BP isoforms a and c each contain one immunoglobulin (Ig)-like C2-type domain which is essential to the binding and neutralizing properties of the binding proteins. The IL-18 BP isoforms b and d lack a complete Ig domain. The expression of IL-18 and the IL-18BP are indentified in immune tissues such as the spleen, but also in nonimmune cells including keratinocytes.