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2,6-Dibromopyridin-4-ol
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2,6-Dibromopyridin-4-ol
Catalog Number:
(76084-104)
Supplier:
Bioss
Description:
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Supplier:
BeanTown Chemical
Description:
CAS: 189807-21-4; MDL No: MFCD00061158
UN No: UN3265; Haz Class: 8; Packing Group: II
Liquid; Molecular Formula: C8H3ClF4O; MW: 226.56
Boiling Point: 157°; Flash point: 85°C (185°F)
Density (g/mL): 1.495; Refractive Index: 1.468
Moisture Sensitive
Catalog Number:
(MK337804)
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
DRIERITE®, Indicating (8 Mesh)
Catalog Number:
(10799-562)
Supplier:
Rockland Immunochemical
Description:
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1C, also known as ALK7, is a type I activin receptor and plays a role in cell differentiation, growth arrest and apoptosis. ACVR1C can mediate signaling by ligans such as Nodal, GDF-1/3, activin B and activin AB, all of which can also signal through the ubiquitous activin type I receptor ACVR1B (also known as ALK4). ACVR1C is a novel marker specifically expressed during the late phase of adipocyte differentiation. ACVR1C is dispensable for mouse embryogenesis, which suggests alternative functions for this receptor in postnatal development and tissue homeostasis. ACVR1C plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca2+ signaling.
Supplier:
BeanTown Chemical
Description:
CAS: 10026-07-0; EC No: 233-055-6; MDL No: MFCD00011262; RTECS: WY2635000
UN No: UN3260; Haz Class: 8; Packing Group: II
Crystalline; Linear Formula: TeCl4; MW: 269.41
Melting Point: 224°; Boiling Point: 380°
Density (g/mL): 3.26
Moisture Sensitive
Supplier:
BeanTown Chemical
Description:
CAS: 79-44-7; EC No: 201-208-6; MDL No: MFCD00000635; RTECS: FD4200000
UN No: UN2262; Haz Class: 8; Packing Group: II
Liquid; Linear Formula: (CH3)2NCOCl; Molecular Formula: C3H6ClNO; MW: 107.54
Melting Point: -33°; Boiling Point: 167-168°/775 mmHg; Flash point: 82°C (180°F)
Density (g/mL): 1.168; Refractive Index: 1.453
Moisture Sensitive
Supplier:
BeanTown Chemical
Description:
CAS: 76-83-5; EC No: 200-986-4; MDL No: MFCD00000813; RTECS: PA6450000
UN No: UN3261; Haz Class: 8; Packing Group: II
Powder; Linear Formula: (C6H5)3CCl; Molecular Formula: C19H15Cl; MW: 278.78
Melting Point: 109-112°
Moisture Sensitive
Supplier:
BeanTown Chemical
Description:
CAS: 98-88-4; EC No: 202-710-8; MDL No: MFCD00000653
UN No: UN1736; Haz Class: 8; Packing Group: II
Liquid; Molecular Formula: C7H5ClO; MW: 140.57
Melting Point: -1°; Boiling Point: 198°; Flash point: 72°C (162°F)
Density (g/mL): 1.211; Refractive Index: 1.553
Moisture Sensitive
Catalog Number:
(10072-560)
Supplier:
Prosci
Description:
EGF Receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally related protein ligands, including TGF, HB-EGF, Betacellulin (BTC), Amphiregulin, Epiregulin, and Epigen. Upon activation, EGFR initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers. Recombinant soluble human EGFR is a 621 amino acid glycoprotein comprising the extracellular domain of EGFR, and migrates at an apparent MW of 97.5 kDa by SDS-PAGE analysis under reducing conditions.
Supplier:
BeanTown Chemical
Description:
CAS: 14996-61-3; EC No: 233-044-6; MDL No: MFCD00149750
UN No: UN3260; Haz Class: 8; Packing Group: II
Crystalline; Molecular Formula: IrCl3·xH2O; MW: 298.56 (anhydrous)
Density (g/mL): 5.3
Catalog Number:
(PAM7660)
Supplier:
Promega Corporation
Description:
Includes GoTaq DNA polymerase and PCR Nucleotide Mix, along with high-performance buffers and magnesium chloride. Core System II also includes a Positive Control Plasmid DNA and Positive Control Primers. Performance-tested in PCR.
Supplier:
BeanTown Chemical
Description:
CAS: 68641-49-6; MDL No: MFCD00010077; RTECS: SZ5871000
UN No: UN3261; Haz Class: 8; Packing Group: II
Crystalline; Molecular Formula: C6H8ClN2O5P; MW: 254.56
Melting Point: 191° (decomposes)
Moisture Sensitive
Supplier:
PeproTech, Inc.
Description:
Myostatin is a TGF-β family member that acts as an inhibitor of skeletal muscle growth. This muscle-specific cytokine interacts with Activin type I and type II receptors, and suppresses myoblast proliferation by arresting cell-cycle in the G1 phase. Suppression of myostatin activity facilitates muscle formation, and may be useful in reducing and/or preventing adiposity and type-2 diabetes. Myostatin activity can be blocked by the activin-binding protein follistatin, and by the propeptide of myostatin. The amino acid sequence of mature myostatin is extremely conserved across species, and is the same in murine, rat, chicken, turkey, porcine, and human. Myostatin is expressed as the C-terminal part of a precursor polypeptide, which also contains a short N-terminal signal sequence for secretion, and a propeptide of 243 amino acids. After dimerization of this precursor, the covalent bonds between the propeptide and the mature ligand are cleaved by furin-type proteases. However, the resulting two proteins remain associated through non-covalent interactions, and are secreted as a latent complex. Recombinant Human/Murine/Rat Myostatin is a 25.0 kDa protein consisting of two identical 109 amino acid polypeptides linked by a single disulfide bond.
Catalog Number:
(76084-106)
Supplier:
Bioss
Description:
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Supplier:
BeanTown Chemical
Description:
CAS: 10026-03-6; EC No: 233-053-5; MDL No: MFCD00011225
UN No: UN2923; Haz Class: 8 (6.1); Packing Group: II
Lump; Linear Formula: SeCl4; MW: 220.77
Melting Point: 170-196°; Boiling Point: 288°
Density (g/mL): 2.6; Refractive Index: 1.807
Moisture Sensitive
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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