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4-Bromo-5-(trifluoromethyl)-1H-indazole
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4-Bromo-5-(trifluoromethyl)-1H-indazole
Catalog Number:
(102837-926)
Supplier:
Matrix Scientific
Description:
3-(Trifluoromethyl)quinoline-4-carboxylic acid ≥97%
Catalog Number:
(102837-310)
Supplier:
Matrix Scientific
Description:
2-[(4-Trifluoromethyl)phenyl]isonicotinic acid ≥97%
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 046694-500MG , MDL Number: MFCD07774162
Supplier:
AOB CHEM USA
Description:
(4-Fluoro-3-(trifluoromethyl)phenyl)(methyl)sulfane ≥97%
Supplier:
APOLLO SCIENTIFIC
Description:
2-Amino-5-(trifluoromethyl)benzonitrile
Catalog Number:
(77036-340)
Supplier:
AMBEED, INC
Description:
3-Fluoro-2-(trifluoromethyl)pyridine 97%
Catalog Number:
(77101-610)
Supplier:
AMBEED, INC
Description:
5-Fluoro-2-(trifluoromethyl)benzonitrile 98%
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 050893-500MG , MDL Number: MFCD13561264
Catalog Number:
(101814-386)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 022615-500MG , MDL Number: MFCD09800633
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 053306-500MG , MDL Number: MFCD13562703
Catalog Number:
(101927-320)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 064234-500MG , MDL Number: MFCD03422717
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 053150-500MG , MDL Number: MFCD13562605
Catalog Number:
(101783-154)
Supplier:
Matrix Scientific
Description:
MF=C8H3Clf4O MW=226.56 Cas=186517-29-3 MDL=MFCD01631343 ,5G
Catalog Number:
(102839-738)
Supplier:
Matrix Scientific
Description:
Methyl-2-chloro-6-(trifluoromethyl)nicotinate ≥97%
Catalog Number:
(102837-550)
Supplier:
Matrix Scientific
Description:
5-(3-Chlorophenyl)-2-(trifluoromethyl)-3-furoic acid ≥97%
Catalog Number:
(10300-356)
Supplier:
Bioss
Description:
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide (NO). The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide. It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme-containing heterodimer, consisting of one alpha subunit and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide (CO), which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity. The distribution of the beta-2 subunit seems to be much more restricted than the beta-1 subunit, with predominant expression in kidney and liver.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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