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2-(4-Methoxyphenyl)isonicotinonitrile
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2-(4-Methoxyphenyl)isonicotinonitrile
Catalog Number:
(76262-770)
Supplier:
Rockland Immunochemical
Description:
In muscle tissue, collagen serves as a major component of the endomysium. Collagen constitutes one to two percent of muscle tissue, and accounts for 6% of the weight of strong, tendinous muscles. A collagen may be defined as a protein containing sizable domain(s) of triple-helical conformation. Type IV collagen is a major macromolecular constituent of basement membranes and can be readily isolated from basement-membrane-rich tissues or highly vascularized tissues such as the placental villi. This collagen appears to be largely restricted to structures identifiable as basement membranes. In contrast, type VI collagen appears to be prevalent in several tissues even though it has been isolated largely from placental villi preparations. The extent to which type VII and VIII collagens are distributed is not known.
Supplier:
BeanTown Chemical
Description:
CAS: 7757-79-1; EC No: 231-818-8; MDL No: MFCD00011409; RTECS: TT3700000
UN No: UN1486; Haz Class: 5.1; Packing Group: III
Crystalline; Molecular Formula: KNO3; MW: 101.11
Melting Point: 334°; Boiling Point: 400° (decomposes)
Density (g/mL): 2.109
Hygroscopic
Catalog Number:
(10357-818)
Supplier:
Bioss
Description:
Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.
Catalog Number:
(100243-442)
Supplier:
Southern Biotechnology
Description:
The lymphocyte Fcγ receptors recognize the Fc portion of IgG, presented either as immune complexes or as free antibody. The different classes of receptors are distinct because of varying size, tissue distribution and affinity for IgGs. The Fc type II receptor is expressed on a wide variety of cells including B cells, hematopoietic cells, monocyte/macrophages, neutrophils, platelets, Langerhans cells, eosinophils, basophils, trophoblasts, and endothelial cells of the placenta. The Fcγ type III receptors are higher affinity than the type II and are expressed on macrophages, NK cells and neutrophils. Both types of receptors can be expressed on the same cell and in varying ratios. The receptors are constitutively expressed, although cytokines and lymphokines can modulate their expression. Besides identifying FcγR+ cells, monoclonal antibodies to the FcγII/III receptor have been used to block Fc receptor binding of IgG, Fc-mediated signal transduction and effector functions, clearance of immune complexes and to attenuate infection by organisms dependent on FcγR for parasitic invasion. The monoclonal antibody 93 recognizes a conformational epitope formed by FcγII and FcγIII receptors.
Catalog Number:
(76948-920)
Supplier:
SCAT AMERICAS, INC.
Description:
Replacement parts for SCAT 'MARCO' V2.0 safety funnels, which can be closed safely and prevent the danger of ignition.
Supplier:
BeanTown Chemical
Description:
CAS: 108-48-5; EC No: 203-587-3; MDL No: MFCD00006345; RTECS: OK9700000
UN No: UN1993; Haz Class: 3; Packing Group: III
Liquid; Molecular Formula: C7H9N; MW: 107.15
Melting Point: -6°; Boiling Point: 143-145°
Density (g/mL): 0.92; Refractive Index: 1.497
Hygroscopic
Catalog Number:
(10364-792)
Supplier:
Bioss
Description:
Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
Supplier:
BeanTown Chemical
Description:
CAS: 10486-00-7; EC No: 239-172-9; MDL No: MFCD00149231; RTECS: SC7350000
UN No: UN1479; Haz Class: 5.1; Packing Group: III
Crystalline/Granular; Linear Formula: NaBO3·4H2O; MW: 153.86
Melting Point: 60° (decomposes)
Density (g/mL): 1.73
Moisture Sensitive
Supplier:
BeanTown Chemical
Description:
CAS: 7440-50-8; EC No: 231-159-6; MDL No: MFCD00010965; RTECS: GL5325000
UN No: UN3089; Haz Class: 4.1; Packing Group: III
8-11 micron APS Powder (FSSS); Molecular Formula: Cu; MW: 63.55
Melting Point: 1083.4°; Boiling Point: 2567°
Density (g/mL): 8.94
Catalog Number:
(10485-122)
Supplier:
Bioss
Description:
FNDC1, also known as MEL4B3, Ags8, Expressed in synovial lining protein and Activation-associated cDNA protein, is a 1888 amino acid secreted protein that contains five fibronectin type-III domains. FNDC1 is moderately expressed in skeletal muscle, pancreas, heart, kidney, spinal cord, ovary and lung. Expression of FNDC1 is induced in response to hypoxia in ventricular cardiomyocytes. Since FNDC1 interacts with G∫ and G©, it is likely that FNDC1 is an activator for G-protein signaling. Though normally absent in healthy skin, FNDC1 expression is induced by TGF-beta signaling in skin tumors and psoriasis. There are two isoforms of FNDC1 that are produced as a result of alternative splicing events.
Supplier:
BeanTown Chemical
Description:
CAS: 876107-33-4; MDL No: MFCD00236530
UN No: UN1188; Haz Class: 3; Packing Group: III
Liquid; Molecular Formula: C12H28CeO8 ; MW: 440.47
Density (g/mL): 1.02
Moisture Sensitive
Supplier:
BeanTown Chemical
Description:
CAS: 55563-79-6; MDL No: MFCD03427200
UN No: UN1987; Haz Class: 3; Packing Group: III
Liquid; Molecular Formula: C5H10O; MW: 86.13
Boiling Point: 115-116°; Flash point: 30°C (86°F)
Density (g/mL): 0.837; Refractive Index: 1.424; Optical Rotation: [α]20/D +5.0°, c = 1% in chloroform
Catalog Number:
(10485-118)
Supplier:
Bioss
Description:
FNDC1, also known as MEL4B3, Ags8, Expressed in synovial lining protein and Activation-associated cDNA protein, is a 1888 amino acid secreted protein that contains five fibronectin type-III domains. FNDC1 is moderately expressed in skeletal muscle, pancreas, heart, kidney, spinal cord, ovary and lung. Expression of FNDC1 is induced in response to hypoxia in ventricular cardiomyocytes. Since FNDC1 interacts with G∫ and G©, it is likely that FNDC1 is an activator for G-protein signaling. Though normally absent in healthy skin, FNDC1 expression is induced by TGF-beta signaling in skin tumors and psoriasis. There are two isoforms of FNDC1 that are produced as a result of alternative splicing events.
Supplier:
BeanTown Chemical
Description:
CAS: 12070-08-5; EC No: 235-120-4; MDL No: MFCD00011268; RTECS: XR1903500
UN No: UN3178; Haz Class: 4.1; Packing Group: III
30-50nm APS Powder, S.A. 35-45 m2/g; Linear Formula: TIC; MW: 59.89
Melting Point: 3140°; Boiling Point: 4820°
Density (g/mL): 4.93
Catalog Number:
(102995-406)
Supplier:
Cell Sciences
Description:
Flow Cytometry: Use 10 µl to label 1x10E6 cells or 100 µl of whole blood.
Catalog Number:
(100243-446)
Supplier:
Southern Biotechnology
Description:
The lymphocyte Fcγ receptors recognize the Fc portion of IgG, presented either as immune complexes or as free antibody. The different classes of receptors are distinct because of varying size, tissue distribution and affinity for IgGs. The Fc type II receptor is expressed on a wide variety of cells including B cells, hematopoietic cells, monocyte/macrophages, neutrophils, platelets, Langerhans cells, eosinophils, basophils, trophoblasts, and endothelial cells of the placenta. The Fcγ type III receptors are higher affinity than the type II and are expressed on macrophages, NK cells and neutrophils. Both types of receptors can be expressed on the same cell and in varying ratios. The receptors are constitutively expressed, although cytokines and lymphokines can modulate their expression. Besides identifying FcγR+ cells, monoclonal antibodies to the FcγII/III receptor have been used to block Fc receptor binding of IgG, Fc-mediated signal transduction and effector functions, clearance of immune complexes and to attenuate infection by organisms dependent on FcγR for parasitic invasion. The monoclonal antibody 93 recognizes a conformational epitope formed by FcγII and FcγIII receptors.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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