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Vanadium+oxytrifluoride
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Vanadium+oxytrifluoride
Catalog Number:
(10070-040)
Supplier:
Prosci
Description:
Required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Inhibition of CDC25 activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Binds to and phosphorylates RAD51 at 'Thr-309', which may enhance the association of RAD51 with chromatin and promote DNA repair by homologous recombination. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may affect chromatin assembly during S phase or DNA repair. May also phosphorylate multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and enhances suppression of cellular proliferation.
Supplier:
AMBEED, INC
Description:
Boc-trans-4-Tosyloxy-L-proline methyl ester, Purity: 95%, CAS Number: 88043-21-4, Appearance: Form: Crystal - Powder / Colour: White - Pale yellow, Storage: Inert atmosphere, 2-8 deg C, Size: 1g
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Human CD34 Protein, His Tag, Source: expressed from human 293 cells (HEK293). It contains AA Ser 32 - Thr 290, Predicted N-terminus: Ser 32, protein carries a polyhistidine tag at the C-terminus, Synonyms: CD34, RP11-328D5.2, Size: 1mg
Catalog Number:
(10411-694)
Supplier:
Bioss
Description:
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Also phosphorylates NEK6. Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination. Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation. Also promotes repair of DNA cross-links through phosphorylation of FANCE. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may enhance chromatin assembly both in the presence or absence of DNA damage. May also play a role in replication fork maintenance through regulation of PCNA.
Supplier:
AMBEED, INC
Description:
(2S,4S)-1-tert-Butyl-2-methyl-4-hydroxypyrrolidine-1,2-dicarboxylate 97%
Supplier:
AMBEED, INC
Description:
Methyl (tert-butoxycarbonyl)-L-phenylalaninate, Purity: 97%, CAS Number: 51987-73-6, Appearance: Form: Crystal - Powder / Colour: White - Almost white - Yellow, Storage: Sealed in dry, Room Temperature, Size: 10G
Catalog Number:
(77298-178)
Supplier:
AMBEED, INC
Description:
(S)-Methyl-2-amino-3-phenylpropanoate 97%
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
L-Serine, USP - GenAR®
Supplier:
AMBEED, INC
Description:
Fmoc-O-trityl-L-serine 97%
Supplier:
Bachem Americas
Description:
Sequence: Boc-Ser-OH
Catalog Number:
(76830-858)
Supplier:
AMBEED, INC
Description:
Methoxy(cyclooctadiene)rhodium(I) dimer, Purity: 98% Rh greater than 42%, CAS Number: 12148-72-0, Appearance: Form: solid, Storage: Inert atmosphere, 2-8C, Size: 50MG
Catalog Number:
(76713-828)
Supplier:
AFG BIOSCIENCE LLC
Description:
Human Omentin (Omentin) ELISA Kit
Supplier:
AMBEED, INC
Description:
5-Methoxy-DL-tryptophan 98%
Supplier:
Bachem Americas
Description:
Sequence: Z-Ser-OBzl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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