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tert-Butyl+4-bromo-3-methoxybenzoate
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tert-Butyl+4-bromo-3-methoxybenzoate
Catalog Number:
(10448-338)
Supplier:
Bioss
Description:
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
Catalog Number:
(10448-332)
Supplier:
Bioss
Description:
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
Catalog Number:
(10269-414)
Supplier:
Bioss
Description:
The HUNK (hormonally upregulated Neu-associated kinase) protein, also designated MAK-V in mouse, has been identified as a novel SNF1-related serine/threonine kinase. The human HUNK gene localizes to chromosome 21q22 and encodes a protein with nucleocytoplasmic distribution and localizes to the centrosome. Overexpression of the HUNK protein associates with approximately 50% of breast carcinomas, and may provide diagnostic-prognostic value as a molecular marker. Serine/threonine-protein kinase SNF1-like kinase 2 (SIK) phosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes, which may modulate the efficiency of insulin signal transduction. SIK is activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter-α and CAB39.
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 052577-500MG , MDL Number: MFCD13562311
Catalog Number:
(10258-974)
Supplier:
Bioss
Description:
Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin-dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating the cell cycle by binding to cyclin-Cdk complexes and modulating their activity. CDKL5 (cyclin-dependent kinase-like 5) is a 1030 amino acid protein that belongs to the CMGC Ser/Thr protein kinase family. Expressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis, CDKL5 is thought to play a role in cell cycle regulation. Defects in CDKL5 are a cause of several disorders, such as X-linked infantile spasm syndrome and Rett syndrome.
Catalog Number:
(103459-104)
Supplier:
HCL Label
Description:
HCL's class 2M laser in use label is made of a durable adhesive vinyl, and made to last.
Supplier:
TCI America
Description:
CAS Number: 10523-68-9
MDL Number: MFCD00074743 Molecular Formula: C10H17N Molecular Weight: 187.71 Purity/Analysis Method: >99.0% (T) Form: Crystal Melting point (°C): 280
Supplier:
TLC PHARMACEUTICAL STANDARD LTD
Description:
Pharmaceutical Standards, Verapamil EP Impurity N HCl (Mixture of Diastereomers)
Catalog Number:
(77289-764)
Supplier:
AMBEED, INC
Description:
4-(Aminomethyl)phenylboronic acid pinacol ester hydrochloride 98%
Supplier:
Thermo Scientific Chemicals
Description:
MDL: MFCD00064563
Beilstein Registry No.: 4711993
Supplier:
Bachem Americas
Description:
Sequence: H-trans-4,5-Dehydro-DL-Lys-OH · 2 HCl
Catalog Number:
(AAJ61595-MC)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 026725-100G , MDL Number: MFCD00006063
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 042816-5G , MDL Number: MFCD00834957
Supplier:
TLC PHARMACEUTICAL STANDARD LTD
Description:
2-Chloro-N-Methylethanamine HCl, TLC Pharmaceutical Standards
Supplier:
Thermo Scientific Chemicals
Description:
Decomposes in water. Soluble in dilute HCl
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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