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Catalog Number:
(89360-116)
Supplier:
Genetex
Description:
The Peroxiredoxin (Prdx, Prx, or Trx-Px) family of enzymes is a recently identified family of peroxidases found in free-living organisms. The six known isoforms (Prx1-6) play an important role in protecting lipids, enzymes and DNA against peroxides, such as hydrogen peroxide. The ubiquitously expressed peroxiredoxins have also been shown to play a role in apoptosis and cell differentiation. This is acomplished by the active cysteine of Prx reducing peroxides, which is then converted into a transient cysteine sulfenic acid or cysteine sulfinic acid. If Prx protection is inadequate against peroxidases, the resulting protein and DNA damage may result in neurological disease such as Alzheimer's or DNA damage leading to cancer.
Catalog Number:
(102552-916)
Supplier:
BioVendor
Description:
FGF-23 is a secreted, nonglycosylated monomeric protein belonging to the FGF family. Full-lenght FGF-23 is a phosphaturic hormone which blocks neural phosphate reabsorbtion. Upon processing, biologically inactive N- and C- terminal fragments are generated. Defects in FGF-23 is associated with autosomal dominant hypophosphatemic rickets. The FGF-23 gene encodes a member of the fibroblast growth factor family that is mutant in autosomal dominant hypophosphatemic rickets (ADHR). Tumor-induced osteomalacia is one of the paraneoplastic disorders characterized by hypophosphatemia caused by renal phosphate wasting. The fact that removal of responsible tumors normalizes phosphate metabolism is evidence that a humoral phosphaturic factor, sometimes called phosphatonin, is the basis of tumor-induced osteomalacia. Thus, overproduction of FGF-23 causes tumor-induced osteomalacia, whereas mutations in the FGF-23 gene result in autosomal hypophosphatemic rickets possibly by preventing proteolytic cleavage, which enhances the biologic activity of FGF-23. The mutations in FGF-23 found in ADHR lie within 3 nucleotides of each other in the proprotein convertase cleavage site. Jonsson et al. (2003) showed that FGF-23 is readily detectable in the plasma or serum of healthy persons and can be markedly elevated in those with oncogenic osteomalacia or X-linked hypophosphatemia, suggesting that this growth factor has a role in phosphate homeostasis.
Catalog Number:
(10460-774)
Supplier:
Bioss
Description:
NT5C1A dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. It helps to regulate adenosine levels in the heart during ischemia and hypoxia.
Catalog Number:
(102138-140)
Supplier:
Novus Biologicals
Description:
AK2 Overexpression Lysate (Adult Normal)
Supplier:
Adipogen
Description:
Potent platinum-based antineoplastic agent. Anticancer compound. Forms inter- and intrastrand DNA adducts/crosslinks, consequently blocking DNA replication and transcription and inducing cell death. Nephrotoxic when used in vivo. Potent chemoimmunotherapeutic. Stimulates the immune responses by activating macrophages and other cells of the immune system. Apoptosis inducer via p53-dependent and -independent mechanisms. Induces apoptosis through caspase-3 activation and XIAP expression inhibition. Targets other proteins and enzymes. Non-competitive NHE-1 inhibitor, an archetypal, membrane-bound mechanosensitive sodium-hydrogen ion transporter.
Supplier:
Electron Microscopy Sciences
Description:
All of our Earle’s Balanced Salt Solution contains: Potassium Chloride, Sodium Chloride, Sodium Phosphate Monobasic, and D-glucose. Some formulations may contain additional components. All of the solutions are prepared 1X strength.
Supplier:
Bachem Americas
Description:
Sequence: sn-Glycero-3-phosphocholine
Synonym(s): Choline alfoscerate#L-α-GPC#L-α-Lecithin
Catalog Number:
(RLP100)
Supplier:
Rockland Immunochemical
Description:
Suitable for use in peroxidase enzymatic labeling experiments.
Catalog Number:
(10081-294)
Supplier:
Proteintech
Description:
ENTPD8, also named as UNQ2492 and PRO5779, belongs to the GDA1/CD39 NTPase family. ENTPD8 is a canalicular ectonucleoside NTPDase which responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolyzis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP. ENTPD8 catalyze the reaction :ATP + 2 H2O = AMP + 2 phosphate.
Supplier:
New England Biolabs (NEB)
Description:
Catalyzes the formation of a phosphodiester bond between juxtaposed 5' phosphate and 3' hydroxyl termini in duplex DNA or RNA.
Catalog Number:
(76337-158)
Supplier:
MP Biomedicals
Description:
Hemoglobin Monoclonal Antibody, clone: HB01, Host: Mouse, Species Reactivity: human, Isotype: IgG1, Solubility: Soluble in water, in 10 mM Phosphate Buffer at pH 7.4, containing 0.9 % NaCl and 0.02% NaN3, size: 0.5
Catalog Number:
(10285-434)
Supplier:
Bioss
Description:
Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins; iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE–BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide.
Supplier:
Hardy Diagnostics
Description:
Amies media is Stuart's original media formula modified by replacing the glycerophosphate in the original formula for an inorganic phosphate buffer.
Catalog Number:
(ABCA_AB204473-100U)
Supplier:
ABCAM INC.
Description:
Anti-Glucose 6 Phosphate Dehydrogenase Rabbit Monoclonal Antibody [clone: EPR6292] (Alexa Fluor® 647)
Catalog Number:
(76337-160)
Supplier:
MP Biomedicals
Description:
IgG Monoclonal Antibody, clone: HIgG01, Host:Mouse, Species Reactivity: human, Isotype: IgM, in 10 mM Phosphate Buffer at pH 7.4, containing 0.9 % NaCl and 0.02% NaN3, storage: -20 deg C, size: 0.5 mg
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is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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