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5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one
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5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one
Supplier:
BeanTown Chemical
Description:
CAS: 14098-44-3; EC No: 237-947-6; MDL No: MFCD00005945; RTECS: DI5400000
Powder/Flakes; Molecular Formula: C14H20O5; MW: 268.31
Melting Point: 78-80°
Hygroscopic
Supplier:
AMBEED, INC
Description:
tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate 95%
Catalog Number:
(77096-724)
Supplier:
AMBEED, INC
Description:
Methyl 2-amino-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylate 95%
Catalog Number:
(12777-846)
Supplier:
VWR International
Description:
Small, lightweight unit takes temperature readings of any surface in less than one second.
Supplier:
Adipogen
Description:
Aurora kinases constitute a family of serine-threonine kinases that are strongly associated with cancer. Aurora A and B are essential in mitosis. Perturbation of their activity leads to multiple defects in mitosis including aberrant centrosome duplication, misalignment of chromosomes, inhibition of cytokinesis, and disruption of the spindle checkpoint. The role of Aurora C is unclear; however, Aurora C can complement Aurora B kinase activity in mitosis. SNS-314 is an ATP-competitive, selective, and potent nanomolar inhibitor of aurora kinases in vitro. A cocrystal structure of SNS-314 with Aurora A confirms that SNS-314 engages the purine-binding pocket of Aurora. SNS-314 inhibits cellular proliferation in the HCT116 colorectal carcinoma cell line with an EC50 of ~5nM. Analysis of DNA content and indirect immunofluoresence demonstrates that SNS-314 induces defects in cytokinesis and spindle checkpoint that are consistent with Aurora kinase inhibition. Phosphorylation of Histone H3 on serine 10, a known Aurora B cellular target, is inhibited with an EC50 of ~9nM following treatment of cells with SNS-314. Administration of SNS-314 to HCT116 tumor bearing mice potently suppresses tumor growth. Analysis of SNS-314 treated tumors confirms that the anti-tumor activity is consistent with Aurora kinase inhibition. SNS-314 is a potent small-molecule inhibitor of Aurora kinase that is being developed as a novel anti-cancer therapeutic agent.
Supplier:
VWR International
Description:
These autoclavable tube racks have a six-way connection to create various configurations and are designed to hold round, flat and conical blood collection and culture tubes.
Supplier:
AMBEED, INC
Description:
2,5-Dioxopyrrolidin-1-yl 4,7,10,13-tetraoxahexadec-15-yn-1-oate ≥98%
Supplier:
VWR International
Description:
General purpose GC-MS column Solvent impurities, PCBs, SimDist, drugs, natural gases, essential oils, semivolatiles, pesticides, phenols, etc.
Supplier:
AMBEED, INC
Description:
Dichloro(1,5-cyclooctadiene)palladium(II), Purity: 98%, CAS Number: 12107-56-1, Appearance: Form: Crystal - Powder, Storage: Inert atmosphere, Room Temperature, Size: 5G
Catalog Number:
(MFLX33501-15)
Supplier:
VWR International
Description:
Obtain accurate flow readings without introducing a new material to the fluid path.
Catalog Number:
(101941-810)
Supplier:
Matrix Scientific
Description:
MF=C6H4Brn3 MW=198.03 Cas=356560-80-0 MDL=MFCD08689534 1G
Catalog Number:
(76671-452)
Supplier:
AMBEED, INC
Description:
[1,2,4]Triazolo[1,5-a]pyridine-8-carbaldehyde, Purity: 95%, CAS Number: 1369366-88-0, Appearance: Solid, Storage: Inert atmosphere, 2-8C, Size: 250MG
Supplier:
BeanTown Chemical
Description:
CAS: 38465-86-0; MDL No: MFCD00064800
Crystalline; Molecular Formula: C34H38F6IrP3; MW: 845.79
Melting Point: 224° (decomposes)
Air Sensitive, Moisture Sensitive
Supplier:
Strem Chemicals Inc
Description:
Metal Beta-diketonates, Volatile Precursors for CVD
Supplier:
Matrix Scientific
Description:
MF=C5H3BRN4 MW=199.02 CAS=935547-73-2 MDL=MFCD12923113 5G
Catalog Number:
(TCN0439-025G)
Supplier:
TCI America
Description:
CAS Number: 20779-13-9
MDL Number: MFCD00059544 Molecular Formula: C12H12O6S2 Molecular Weight: 316.34 Purity/Analysis Method: >98.0% (GC) Form: Crystal Melting point (°C): 203
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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