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Cyclopropyl(2,3-dichloropyridin-4-yl)methanone
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Cyclopropyl(2,3-dichloropyridin-4-yl)methanone
Catalog Number:
(101816-790)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 023803-1G , MDL Number: MFCD06411542
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 048325-1G , MDL Number: MFCD00042378
Catalog Number:
(10481-178)
Supplier:
Bioss
Description:
Dihydropyrimidine dehydrogenase (DPYD) catalyzes the first rate-limiting step of the NADPH-dependent catabolism of uracil and thymine to dihydrouracil and dihydrothymine; thus, a deficiency of DPYD leads to an accumulation of uracil and thymine. Abnormal concentrations of these metabolites in bodily fluids may be the cause of neurological disease and a contraindication for treatment of cancer patients with certain pyrimidine analogs. DPYD also catalyzes the anticancer agent 5-fluorouracil (5-FU) pathway and is involved in the efficacy and toxicity of 5-FU. Variations in DPYD concentration may arise from alterations at the transcriptional level of the dihydropyrimidine dehydrogenase gene. Specifically, hypermethylation of the DPYD promoter downregulates dihydropyrimidine dehydrogenase expression. Deficient DPYD alleles may constitute a risk factor for severe toxicity following treatment with 5-FU.Involvement in disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) ; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.
Supplier:
AMBEED, INC
Description:
R-(-)-1,13-Bis(diphenylphosphino)-7,8-dihydro-6H-dibenzo[f,h][1,5]dioxonin 98%
Catalog Number:
(101816-788)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 023802-1G , MDL Number: MFCD06739029
Catalog Number:
(102838-416)
Supplier:
Matrix Scientific
Description:
Pyrazolo[1,5-a]pyridine-2-carboxylic acid ≥97%
Catalog Number:
(76647-666)
Supplier:
AMBEED, INC
Description:
6-bromo-8-methoxy-[1,2,4]triazolo[1,5-a]pyridine, Purity: 97%, CAS Number: 2171029-30-2, Appearance: Solid, Storage: Sealed in dry, 2-8C, Size: 100MG
Catalog Number:
(102892-648)
Catalog Number:
(76681-912)
Supplier:
AMBEED, INC
Description:
Isopropyl 3-bromo-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate, Purity: 97%, CAS Number: 2682114-53-8, Appearance: White to Yellow Solid, Storage: Sealed in dry, 2-8C, Size: 100MG
Catalog Number:
(TCA0506-025G)
Supplier:
TCI America
Description:
CAS Number: 853-35-0
MDL Number: MFCD00044659 Molecular Formula: C14H8O8S2 Molecular Weight: 412.29 Purity/Analysis Method: >98.0% (T) Form: Crystal
Supplier:
AMBEED, INC
Description:
tert-Butyl 3-bromo-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate, Purity: 97%, CAS number: 1196154-25-2, Appearance: White to Pale-yellow to Yellow-brown Solid, Storage: Sealed in dry, 2-8C, Size: 250MG
Supplier:
VWR International
Description:
Storage carts made from food-grade, high-density polyethylene have four 3" industrial casters, two of which lock.
Supplier:
TCI America
Description:
CAS Number: 18807-74-4
MDL Number: MFCD00270152 Molecular Formula: C13H20N2O2 Molecular Weight: 272.77 Purity/Analysis Method: >98.0% (T) Form: Crystal Melting point (°C): 172
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 046400-1G , MDL Number: MFCD09152731
Supplier:
AMBEED, INC
Description:
1-Bromo-3-(trifluoromethyl)imidazo[1,5-a]pyridine-6-carboxylic acid, Purity: 95%, CAS Number: 1781028-01-0, Appearance: Solid, Storage: Inert atmosphere, 2-8C, Size: 100MG
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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