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Allylpalladium(II)+chloride+dimer
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Allylpalladium(II)+chloride+dimer
Catalog Number:
(JT3625-07)
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Sodium chloride 99.0-100.5% (dried basis), granular USP, Multi-Compendial, J.T.Baker®
Catalog Number:
(BT123680-100ML)
Supplier:
BeanTown Chemical
Description:
CAS: 6362-80-7; EC No: 228-846-8; MDL No: MFCD00044027
UN No: UN3082; Haz Class: 9; Packing Group: III
Liquid; Linear Formula: C6H5C(CH3)2CH2C(C6H5)=CH2; Molecular Formula: C18H20; MW: 236.35
Boiling Point: 161°/5 mmHg; Flash point: 145°C (293°F)
Density (g/mL): 0.99; Refractive Index: 1.569
Catalog Number:
(10285-968)
Supplier:
Bioss
Description:
Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1.
Catalog Number:
(JT3302-25)
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Sodium chloride 99,0 - 100,5% 99.0-100.5% (dried basis), crystals USP, FCC
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Desiccant, 20 mesh. Lot analysis on label.
Catalog Number:
(97061-302)
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
For refilling calomel reference electrodes.
Catalog Number:
(JT1588-R)
Catalog Number:
(MK683826)
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Granular. GMP manufactured.
Catalog Number:
(MK754406)
Catalog Number:
(JT2255-5)
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
For flame enhancement in atomic absorption spectroscopy. Lot analysis on label.
Supplier:
Avantor Performance Materials
Description:
Suitable for bioprocessing. BSE/TSE free. Endotoxin tested. Custom packaging and testing available. Change management and notification available. Samples available.
Catalog Number:
(10364-294)
Supplier:
Bioss
Description:
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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