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2-Chloro-4-phenylnicotinonitrile
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2-Chloro-4-phenylnicotinonitrile
Catalog Number:
(77987-725)
Supplier:
LGC STANDARDS
Description:
3-Hydroxy Bromazepam 1.0 mg/mL in Methanol, TRC, LGC Standards
Catalog Number:
(100190-204)
Supplier:
Roboz Surgical
Description:
Tissue Forceps; 1 x 2 Teeth; 4.5" Length; 2 mm Tip Width
Catalog Number:
(100190-334)
Supplier:
Roboz Surgical
Description:
Tissue Forceps; 2 x 3 Teeth; 4.5" Length; 2 mm Tip Width
Supplier:
Akro-Mils
Description:
AkroBins are the industry-leading hanging and stacking plastic storage bin.
Catalog Number:
(10756-848)
Supplier:
Biolegend
Description:
Brilliant Violet 711™ anti-mouse CD62L [MEL-14]; Isotype: Rat IgG2a, κ; Reactivity: Mouse; Apps: FC; Size: 50 μg
Supplier:
AMBEED, INC
Description:
(5-Bromo-2-methylphenyl)methanol, Purity: 95%, CAS Number: 258886-04-3, Appearance: White to Yellow Solid, Storage: Sealed in dry, Room Temperature, Size: 5g
Catalog Number:
(10347-104)
Supplier:
Bioss
Description:
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. GRB14 is a potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Supplier:
National Marker
Description:
Alert others of property boundaries and ensure privacy.
Catalog Number:
(TCU0048-025ML)
Supplier:
TCI America
Description:
CAS Number: 23779-32-0
MDL Number: MFCD00047877 Molecular Formula: C10H24N2O4Si Molecular Weight: 264.40 Form: Clear Liquid Color: Colorless Flash Point (°C): 14
Catalog Number:
(10799-454)
Supplier:
Rockland Immunochemical
Description:
14-3-3ε also known as tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein is a member of the 14-3-3 family. 14-3-3ε has been reported to be involved in heat shock transcription factor 1 (HSF1) and extracellular signal regulated protein kinase (ERK) pathways (1). 14-3-3ε interaction with the deubiquitinating enzyme UBPY, also known as USP8, regulates cargo sorting and membrane traffic at early endosomes. Association of 14-3-3ε, HSF1 with ERK during heat shock may modulate the amplitude of the response and control the termination of HSP expression on resumption of growth conditions (2). 14-3-3ε protein is ideal for investigators involved in Cell Stress & Chaperone Proteins, Cell Signaling, Cancer research, Cell Cycle, Cellular Stress, Neurobiology, and WNT Signaling research.
Catalog Number:
(10347-096)
Supplier:
Bioss
Description:
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. GRB14 is a potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Supplier:
National Marker
Description:
Alert employees and guests to smoking policies within your facility.
Supplier:
National Marker
Description:
Signs are the perfect way to alert your employees and guests when a hazard is present in your facility.
Catalog Number:
(77692-693)
Supplier:
LGC STANDARDS
Description:
21-Chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione (Clobetasol), Mikromol, LGC Standards
Catalog Number:
(10347-098)
Supplier:
Bioss
Description:
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. GRB14 is a potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Supplier:
BeanTown Chemical
Description:
CAS: 7429-90-5; EC No: 231-072-3; MDL No: MFCD00134029; RTECS: BD0330000
UN No: UN1396; Haz Class: 4.3; Packing Group: II
Powder; Molecular Formula: Al; MW: 26.98
Melting Point: 660.4°; Boiling Point: 2460°
Density (g/mL): 2.7
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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