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7-Azaindole-5-boronic+acid
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7-Azaindole-5-boronic+acid
Catalog Number:
(10297-730)
Supplier:
Bioss
Description:
GLUD2 is both mitochondrial matrix enzymes belonging to the Glu/Leu/Phe/Val dehydrogenases family. Exisiting as homohexamers, GLUD1 catalyzes the oxidative deamination of glutamate to ?ketoglutarate and ammonia while GLUD2 is involved in the recycling of glutamate during neurotransmission. GLUD1 is critical for regulating amino acid induced insulin secretion and is allosterically activated by ADP and inhibited by GTP and ATP. Mutations in the gene encoding GLUD1 causes hyperinsulinism-hyperammonemia syndrome (HHS), which is an inherited condition characterized by high insulin and ammonia levels in the blood. GLUD1 may also be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. GLUD2 is expressed in testis and retina, with lower levels found in brain.
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Hydrochloric Acid (HCl 36.5%-38.0%), N.F., F.C.C., A.C.S.
Supplier:
BeanTown Chemical
Description:
CAS: 112022-81-8; MDL No: MFCD00078439
UN No: UN1993; Haz Class: 3; Packing Group: II
Liquid; Molecular Formula: C18H20BNO; MW: 277.17
Flash point: 4°C (39°F)
Density (g/mL): 0.929
Air Sensitive, Moisture Sensitive
Catalog Number:
(76803-338)
Supplier:
AMBEED, INC
Description:
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methyl-3-phenylpropanoic acid, Purity: 95%, CAS Number: 135944-05-7, Appearance: White to off-white powder or crystals, Storage: Sealed in dry, 2-8C, Size: 100MG
Catalog Number:
(76979-760)
Supplier:
AMBEED, INC
Description:
N-(1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide, Purity: 98%, CAS number: 110764-74-4, Appearance: White to Yellow Solid, Storage: Sealed in dry, 2-8C, Size: 5G
Supplier:
Matrix Scientific
Description:
[(1-Methylcyclopropyl)methyl]amine hydrochloride
Catalog Number:
(102838-032)
Supplier:
Matrix Scientific
Description:
4-(3-Methoxyphenyl)-1-methylpiperidine-4-carboxylic acid ≥97%
Catalog Number:
(77101-878)
Supplier:
AMBEED, INC
Description:
(4-(((tert-Butyldiphenylsilyl)oxy)methyl)phenyl)methanol 98%
Supplier:
Bachem Americas
Description:
Synonym(s): EDAC · HCl#EDC · HCl#N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide · HCl#Water-soluble Carbodiimide#WSC
Supplier:
AMBEED, INC
Description:
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-fluorophenyl)-2-methylpropanoic acid, Purity: 95%, CAS Number: 1172127-44-4, Appearance: White to off white to light-green powder or crystals, Storage: Sealed in dry, 2-8 C, Size: 5g
Supplier:
Adipogen
Description:
Selective cell permeable and irreversible MALT1 inhibitor. Inhibits NF-kappaB-dependent gene expression and affects the growth, proliferation and survival of activated B cell-like diffuse large B cell lymphomas (ABC-DLBCL) and germinal center B cell like diffuse large B cell lymphoma (GCB-DLBCL) cell lines. Shown to inhibit the autoprocessing activity of MCA2ac (calcium dependent) in Trypanosoma brucei.
Catalog Number:
(76116-350)
Supplier:
Bioss
Description:
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
Catalog Number:
(76747-304)
Supplier:
ANTIBODIES.COM LLC
Description:
Human DNAJB8 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i><i>in vitro</i></i> quantitative determination of human DNAJB8 in serum, plasma, tissue homogenates, and other biological fluids.
Supplier:
Bachem Americas
Description:
This fluorescent (FRET) peptide substrate contains the wild-type amyloid precursor protein (APP) β-secretase cleavage site. Mca-SEVKMDAEFRK(Dnp)RR- amide has been used for assaying β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). The results suggested that TOP is a potential β-secretase candidate and is involved in the processing of APP in vivo. See also L-1905.
Catalog Number:
(10297-458)
Supplier:
Bioss
Description:
GLUD2 is both mitochondrial matrix enzymes belonging to the Glu/Leu/Phe/Val dehydrogenases family. Exisiting as homohexamers, GLUD1 catalyzes the oxidative deamination of glutamate to ?ketoglutarate and ammonia while GLUD2 is involved in the recycling of glutamate during neurotransmission. GLUD1 is critical for regulating amino acid induced insulin secretion and is allosterically activated by ADP and inhibited by GTP and ATP. Mutations in the gene encoding GLUD1 causes hyperinsulinism-hyperammonemia syndrome (HHS), which is an inherited condition characterized by high insulin and ammonia levels in the blood. GLUD1 may also be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. GLUD2 is expressed in testis and retina, with lower levels found in brain.
Catalog Number:
(10284-510)
Supplier:
Bioss
Description:
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins(also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Isoform 2 seems to be proteolytically inactive. [CATALYTIC ACTIVITY] Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues. [SUBUNIT] Homotrimer. Interacts with MXI2. The mature protein, but not the precursor, binds to BIRC2, BIRC3 and XIAP.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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