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4,4'-Diaminostilbene-2,2'-disulfonic+Acid
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4,4'-Diaminostilbene-2,2'-disulfonic+Acid
Catalog Number:
(76084-064)
Supplier:
Bioss
Description:
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
Catalog Number:
(10450-562)
Supplier:
Bioss
Description:
NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.Tissue specificity; Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain.Sequence similarities; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Catalog Number:
(10450-576)
Supplier:
Bioss
Description:
NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.Tissue specificity; Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain.Sequence similarities; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Catalog Number:
(77439-754)
Supplier:
Bioss
Description:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
Supplier:
AMBEED, INC
Description:
2,3-Bis((R)-tert-butyl(methyl)phosphino)quinoxaline, Purity: 95%, CAS Number: 866081-62-1, Appearance: Form: solid, Storage: Inert atmosphere, Room Temperature, Size: 100mg
Supplier:
Enzo Life Sciences
Description:
Potent and selective inhibitor of mammalian Plk1
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine
Supplier:
BeanTown Chemical
Description:
CAS: 4767-03-7; EC No: 225-306-3; MDL No: MFCD00004199
Crystalline; Molecular Formula: C5H10O4; MW: 134.13
Melting Point: 189-191°
Hygroscopic
Catalog Number:
(101833-502)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 032339-1G , MDL Number: MFCD10568564
Catalog Number:
(10341-194)
Supplier:
Bioss
Description:
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.
Supplier:
TCI America
Description:
Bis(4-fluorophenyl)iodonium Trifluoromethanesulfonate, Purity: >97.0%(HPLC)(T), CAS Number: 732306-64-8, Molecular Formula: C13H8F5IO3S, Molecular Weight: 466.16, Synonyms: Bis(4-fluorophenyl)iodonium Triflate, Size: 1G
Supplier:
Adipogen
Description:
Reactive probe containing fluorescent metal-ligand complex for determination of nucleotide base sequences.
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl 98%
Supplier:
TCI America
Description:
CAS Number: 1060-92-0
Molecular Formula: C17H8F12N2S Molecular Weight: 500.31 Purity/Analysis Method: >98.0% (N) Form: Crystal Melting point (°C): 152
Supplier:
TCI America
Description:
1,1-Dibromo-2,2-bis(chloromethyl)cyclopropane, Purity: >96.0%(GC), CAS number: 98577-44-7, Molecular Formula: C5H6Br2Cl2, Molecular Weight: 296.81, Form: Crystal - Powder, White - Pale yellow, Size: 5G
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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