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H-d-Ser(tBu)-OMe\u00B7HCl
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H-d-Ser(tBu)-OMe\u00B7HCl
Catalog Number:
(10402-242)
Supplier:
Bioss
Description:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Catalog Number:
(10348-798)
Supplier:
Bioss
Description:
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Catalog Number:
(10427-498)
Supplier:
Bioss
Description:
The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721).[provided by RefSeq, May 2011].
Catalog Number:
(10410-290)
Supplier:
Bioss
Description:
Vital cellular functions such as cell proliferation and signal transduction are regulated in part by the balance between the activities of protein tyrosine kinases (PTK) and protein tyrosine phosphatases (PTPs). The protein contains a 121 residue extracellular domain, a single transmembrane segment, and 2 tandem intracytoplasmic catalytic domains. The PTP alpha protein is ubiquitously expressed and may play a fundamental role in the physiology of all cells.
Catalog Number:
(10429-100)
Supplier:
Bioss
Description:
A number of specific carrier proteins for members of the vitamin A family have been discovered. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. The inducibility of the CRABP2 gene suggests that this isoform is important in retinoic acid-mediated regulation of human skin growth and differentiation. It has been postulated that the CRABP2 gene is transcriptionally regulated by a newly synthesized regulatory protein.
Catalog Number:
(10470-514)
Supplier:
Bioss
Description:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Catalog Number:
(10448-470)
Supplier:
Bioss
Description:
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity).
Catalog Number:
(10426-752)
Supplier:
Bioss
Description:
The protein encoded by ANP32C is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns.
Catalog Number:
(10411-898)
Supplier:
Bioss
Description:
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation.
Catalog Number:
(10415-928)
Supplier:
Bioss
Description:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008].
Catalog Number:
(10452-308)
Supplier:
Bioss
Description:
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
Catalog Number:
(10327-772)
Supplier:
Bioss
Description:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Catalog Number:
(103392-588)
Supplier:
Novus Biologicals
Description:
The Donkey anti-Rat IgG (H+L) Secondary Antibody [FITC] from Novus Biologicals is a donkey polyclonal antibody to IgG (H+L). This antibody reacts with rat. The Donkey anti-Rat IgG (H+L) Secondary Antibody [FITC] has been validated for the following applications: Flow Cytometry, Immunomicroscopy.
Catalog Number:
(103392-428)
Supplier:
Novus Biologicals
Description:
The Rabbit anti-Mouse IgG (H+L) Secondary Antibody [FITC] from Novus Biologicals is a rabbit polyclonal antibody to IgG (H+L). This antibody reacts with mouse. The Rabbit anti-Mouse IgG (H+L) Secondary Antibody [FITC] has been validated for the following applications: Flow Cytometry, Immunomicroscopy.
Catalog Number:
(103393-096)
Supplier:
Novus Biologicals
Description:
The Donkey anti-Sheep IgG (H+L) Secondary Antibody [FITC] from Novus Biologicals is a donkey polyclonal antibody to IgG (H+L). This antibody reacts with sheep. The Donkey anti-Sheep IgG (H+L) Secondary Antibody [FITC] has been validated for the following applications: Flow Cytometry, Immunomicroscopy.
Catalog Number:
(103392-456)
Supplier:
Novus Biologicals
Description:
The Donkey anti-Rabbit IgG (H+L) Secondary Antibody [FITC] from Novus Biologicals is a donkey polyclonal antibody to IgG (H+L). This antibody reacts with rabbit. The Donkey anti-Rabbit IgG (H+L) Secondary Antibody [FITC] has been validated for the following applications: Flow Cytometry, Immunomicroscopy.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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