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Cyclohexanemethyl+isothiocyanate
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Cyclohexanemethyl+isothiocyanate
Catalog Number:
(100243-024)
Supplier:
Southern Biotechnology
Description:
CD106, also known as VCAM-1, is an adhesion molecule and a major mediator of the inflammatory response. It is expressed on activated microvascular endothelial cells in response to signals arising from immune responses in infection, graft rejection, tumor recognition and killing. The complementary binding ligand for VCAM-1 is VLA-4/CD49d. In addition to VCAM-1, VLA-4 also recognizes the extracellular matrix molecule fibronectin. This pairing of VCAM-1 and VLA-4 is able to provide a second signal (e.g., non-antigen specific) for T cell stimulation, such as that seen in transplantation. The monoclonal antibody MK-2 has been used in transplant studies to suppress cardiac rejection and induce long-term cardiac graft survival. In addition to inflammatory responses, VCAM-1 has a significant role in hemopoiesis through its ability to retain lymphocyte and myeloid precursors on stromal cells in the marrow and lymphoid organs. CD106/VCAM-1 exists as an integral membrane protein. The M/K-2 monoclonal antibody immunoprecipitates a peptide that gives a single band on SDS-PAGE gels with an apparent Mr of ~100 kDa under reducing conditions and 92 kDa under non-reducing conditions.
Catalog Number:
(10365-780)
Supplier:
Bioss
Description:
Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.
Supplier:
Biolegend
Description:
FITC anti-mouse CD45.2 [104]; Isotype: Mouse (SJL) IgG2a, κ; Reactivity: Mouse; Apps: FC; Size: 500 μg
Supplier:
Biolegend
Description:
FITC anti-mouse CD8a [5H10-1]; Isotype: Rat (SD) IgG2b, λ; Reactivity: Mouse; Apps: FC; Size: 500 μg
Catalog Number:
(10757-552)
Supplier:
Biolegend
Description:
FITC anti-rat CD38 [14.27]; Isotype: Mouse IgG2b, κ; Reactivity: Rat; Apps: FC; Size: 50 μg
Supplier:
Biolegend
Description:
FITC anti-human CD105 [43A3]; Isotype: Mouse IgG1, κ; Reactivity: Human; Apps: FC; Size: 100 tests
Supplier:
Biolegend
Description:
FITC anti-human CD1a [HI149]; Isotype: Mouse IgG1, κ; Reactivity: Human; Apps: FC; Size: 100 tests
Catalog Number:
(302704-BL)
Supplier:
Biolegend
Description:
FITC anti-human CD26 [BA5b]; Isotype: Mouse IgG2a, κ; Reactivity: Human; Apps: FC; Size: 100 tests
Catalog Number:
(102113-050)
Supplier:
Novus Biologicals
Description:
The CD45 Antibody (OX-1) [FITC] from Novus Biologicals is a mouse monoclonal antibody to CD45. This antibody reacts with rat. The CD45 Antibody (OX-1) [FITC] has been validated for the following applications: Flow Cytometry.
Catalog Number:
(10257-948)
Supplier:
Bioss
Description:
The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. In fact, UNC5H receptors express widely in cells that migrate, where they bind the G protein G Alpha 1-2 to inhibit G protein signaling. Additionally, UNC5H receptors induce apoptosis when cleaved by a caspase, producing an intracellular fragment containing a death domain, but this activity is blocked by the binding of netrin-1. The expression of UNC5H receptors is down-regulated in multiple cancers, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. Hence, in the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. UNC5H2, also designated unc-5 homolog B or p53-regulated receptor for death and life protein 1 (p53RDL1) is highly expressed in brain with lower levels of expression observed in developing lung, cartilage, kidney and hematopoietic and immune tissues.
Catalog Number:
(10263-062)
Supplier:
Bioss
Description:
Huntingtin yeast partner E is a 458 amino acid single-pass membrane protein. HYPE is thought to interact with Huntingtin, a protein which induces neurodegeneration when mutated. HYPE also contains two tetratricopeptide repeats (TPR), which may be involved in protein-protein interaction. The gene that encodes HYPE is located on chromosome 12, which encodes over 1,100 genes within 132 million bases and makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy.
Catalog Number:
(10764-488)
Supplier:
Prosci
Description:
The 4H11 monoclonal antibody specifically reacts with the Class III epitope of CD34 (mucosialin), a transmembrane phosphoglycoprotein. It is expressed on most hematopoietic progenitors, pluripotent stem cells and tumor cells.
Supplier:
Biolegend
Description:
FITC anti-mouse I-A/I-E [M5/114.15.2]; Isotype: Rat IgG2b, κ; Reactivity: Mouse; Apps: FC; Size: 500 μg
Catalog Number:
(RL200-302-N12)
Supplier:
Rockland Immunochemical
Description:
Anti-CD3 is useful for Immunoprecipitation, immunochemistry, and Flow Cytometry. Researchers should determine optimal titers for applications that are not stated.
Catalog Number:
(305906-BL)
Supplier:
Biolegend
Description:
FITC anti-human CD116 [4H1]; Isotype: Mouse IgG1, κ; Reactivity: Human, African Green; Apps: FC; Size: 100 tests
Catalog Number:
(337304-BL)
Supplier:
Biolegend
Description:
FITC anti-human CD172a/b (SIRPα/β) [148]; Isotype: Mouse IgG1, κ; Reactivity: Human; Apps: FC; Size: 100 tests
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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