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DAF-FM+diacetate
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DAF-FM+diacetate
Catalog Number:
(10797-254)
Supplier:
Prosci
Description:
Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the type? subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Toluene, extra dry over Molecular Sieve 99.85%, AcroSealâ„¢
Supplier:
Thermo Scientific Chemicals
Description:
Mordant in dyeing, in the manufacture of bister, as a drier for paints and varnishes, and as an oxidation catalyst
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Rabbit M-CSF R / CSF1R / CD115 Protein, His Tag, ACROBiosystems
Supplier:
Adipogen
Description:
Cell permeable fluorescent probe. Used for site-specific labeling of N-terminal cysteine proteins with the small molecule probes.
Supplier:
Thermo Scientific Chemicals
Description:
3 4 6-Tri-O-Acetyl-D-Galactal, CAS number: 4098-06-0, Molecular Formula: C12H16O7, Color: Pale yellow, Form:Low melting solid, Size: 5g
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Toluene 99.5% ACS, meets analytical specifications of Reagent Ph. Eur.
Catalog Number:
(BJ20901-500G)
Supplier:
Honeywell Research Chemicals
Description:
Cadmium acetate dihydrate, Purity: min 98.0%, Grade: Reagent Grade, CAS Number: 5743-04-4, Molecular Formula: Cd(OOCCH3)2.2H2O, Formula Weight: 266.54 (230.50anhy), Laboratory Chemical Salt, form: Powder, Size: 500G
Catalog Number:
(100276-078)
Supplier:
Indofine Chemical Company
Description:
Rare Organics & BioChemicals 86060-82-4 5gm Fm[degree]C-Lys(Z)-OH 502.6 Room temperature.
Supplier:
Thermo Scientific Chemicals
Description:
MDL: MFCD00008689
Soluble in water
Catalog Number:
(76082-348)
Supplier:
Bioss
Description:
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.
Catalog Number:
(MK448310)
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Especially intended for use as an HPLC and TLC solvent. Filtered through a 0.2µm element.
Catalog Number:
(EM1.01010.0005)
Supplier:
MilliporeSigma
Description:
For The Spectrophotometric Determination Of Fluoride
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Hexane (mixture of isomers) 99% ACS for spectroscopy
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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