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Dai+Ki+Sciences+Co.+(USD)+Ltd
Supplier:
Electron Microscopy Sciences
Description:
Thermo-Flask provides safe extended temperature retention for specimens stored in liquid nitrogen or solid CO<sub>2</sub>. The flasks features borosilicate glass inner liners which have been evacuate to 1 x 10 – 5 mm of Hg to provide maximum coolant retention.
Catalog Number:
(89161-760)
Supplier:
Enzo Life Sciences
Description:
Sequence is calcineurin (CaN) autoinhibitory domain (rat brain CaN aa 457-482). It inhibits calcineurin with an IC50 of 10 µM using [32P]myosin light chain as substrate. Inhibits Mn2+-stimulated calcineurin activity but has no effect on Ni2+-stimulated activity. Ki=4.4 µM with radiolabeled [Ala97]-RII (81-99) peptide as the phosphatase substrate.
Catalog Number:
(77463-304)
Supplier:
Electron Microscopy Sciences
Description:
Compact battery pack will run the NIGHTSEA® SFA stereo microscope fluorescence adapter system all day long. The battery enables truly portable operation so that users can set up demos anywhere or explore fluorescence in the field.
Catalog Number:
(89160-096)
Supplier:
Enzo Life Sciences
Description:
Primary metabolite of arachidonic acid via the 12-lipoxygenase pathway. Inhibits thromboxane synthase. Inhibits platelet aggregation via activation of guanylate cyclase (100% at 5µM). Stimulates leukotriene biosynthesis. Potent and selective inhibitor of Ca2+-calmodulin-dependent protein kinase II (IC50=0.7µM). Endogenous TRPV1 agonist (Ki=0.35µM).
Catalog Number:
(470104-108)
Supplier:
Humboldt Manufacturing
Description:
A simple wire clamp that may be installed or removed without disconnecting tubing ends.
Supplier:
Enzo Life Sciences
Description:
Slow-binding competitive inhibitor of arginase I (Ki=0.4-0.6µM & KD=2.22µM for recombinant rat liver arginase) and arginase II (Ki=0.31µM at pH 7.5 and 0.03µM at pH 9.5 for human recombinant type II arginase). Enhances NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue. Does not inhibit nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS. Inhibitor of rat aortic smooth muscle cell proliferation.
Supplier:
C & A Scientific
Description:
Classroom supply items for your every day needs.
Supplier:
Enzo Life Sciences
Description:
Highly specific, potent, irreversible, and cell-permeable competitive inhibitor of proprotein convertases: furin/SPC1 (Ki~1nM), SPC2/PC2 (Ki=0.36nM), SPC3/PC1/PC3(Ki=2.0nM), SPC4/PACE4 (Ki=3.6nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (Ki=0.12nM). Because furin activates viral glycoproteins, this inhibitor is a useful antiviral agent. In addition, it inhibits furin-dependent pro-MMP-2 activation in various cell lines, including U87 and HT1080 cells. Typical concentration range used in tissue culture is 25-100µM.
Supplier:
Electron Microscopy Sciences
Description:
ACLAR® is made from fluorinated-chlorinated resins that provide an exceptional moisture barrier. ACLAR® is crystal clear, biochemically inert, highly resistant to most chemicals and sterilizable by heat or radiation. ACLAR® is used widely in pharmaceutical, medical, sensitive electronics and military packaging.
Catalog Number:
(89158-360)
Supplier:
Enzo Life Sciences
Description:
Endogenous cannabinoid. Weak ligand of CB1 (Ki=23.8µM) and CB2 (Ki=13.9µM) receptor. Inhibits fatty acid amide hydrolase (FAAH) (IC50=5.1µM). Immunosuppressant, anti-inflammatory, anti-nociceptive and anti-convulsant in vivo. The exact mode of action has not yet been revealed. It has been suggested that PEA: i) binds to a yet to be discovered cannabinoid receptor similar to CB2; ii) administered in vivo elicits the synthesis of endogenous agonists of CB2; iii) acts as an "entourage" compound by enhancing the activity and/or by influencing the turnover of endogenous agonists of CB2, possibly but not uniquely, by inhibiting their degradation.
Catalog Number:
(89157-762)
Supplier:
Enzo Life Sciences
Description:
Potent and selective inhibitor of MLC kinase (Ki=0.3 µM). It inhibts also smooth-muscle myosin light chain kinase, protein kinase C (PKC) and cAMP-dependent protein kinase (PKA).
Supplier:
Enzo Life Sciences
Description:
Competitive, mechanism-based inhibitor of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9). It possesses Ki values in the nanomolar range against the gelatinases (14nM for MMP-2; 600nM for MMP-9), but in the micromolar range against other metalloproteinases (206µM for MMP-1, 15µM for MMP-3, 96µM for MMP-7, and 4µM for ADAM17/TACE). This inhibitor has also been used in vitro, in vivo, and in tissue culture. In vivo, it is metabolized to an even more potent gelatinase inhibitor.
Supplier:
Enzo Life Sciences
Description:
A competitive, reversible inhibitor of serine proteases tryptase (Ki=3.4nM), thrombin (Ki=500nM), uPA (Ki=1.3µM), plasmin (Ki=1.5µM), trypsin (Ki=2µM), factor Xa (Ki=2µM). At higher concentrations it inhibits kallikrein-1 (Ki=2.6mM), C1 esterase (IC50=520µM), as well as phospholipase A2 (IC50=500µM), rat iNOS (Ki=5mM) and cNOS (Ki=150µM), and swine kidney copper amine oxidase (Ki=27µM), but not chymotrypsin. Has been used in tissue culture and in vivo. In clinical use for pancreatitis.
Supplier:
Enzo Life Sciences
Description:
A potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons. It protects against anoxia in rat optic nerves and reduces neuronal damage in an animal model of global cerebral ischemia(50 mg/kg). In isolated hippocampal pyramidal neurons, it inhibits Ca²⁺-induced suppression of neurite outgrowth (complete inhibition at 20 µM). Calpain I Ki = 8 nM; Cathepsin B Ki = 24 nM in isolated enzyme assays. IC50 = 0.3 µM in intact cell assay.
Catalog Number:
(89157-666)
Supplier:
Enzo Life Sciences
Description:
Selective inhibitor of MLC kinase (Ki=3.8 µM). Inhibits insulin-stimulated 2-deoxyglucose transport and PP-1 activation in adipocytes, possibly via an effect on MAP kinase or its activation. Useful PKB inhibitor (IC50=10-50 µM). Also known to inhibit PKA (IC50=20 µM) and S6 kinase (IC50=50 µM). Does not inhibit PI 3-kinase.
Catalog Number:
(470317-024)
Supplier:
KIDDER MFG. CO. LTD
Description:
A great way to introduce STEM into the classroom with a take-home activity.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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