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Ishikawa\\\'s reagent
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Ishikawa\\\'s reagent
Catalog Number:
(10070-922)
Supplier:
Prosci
Description:
Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3, 4, 5-trisphosphate, phosphatidylinositol 3, 4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1, 3, 4, 5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3, 4, 5)P3 > PtdIns(3, 4)P2 > PtdIns3P > Ins(1, 3, 4, 5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue.
Catalog Number:
(77438-252)
Supplier:
Bioss
Description:
Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A.
Catalog Number:
(76422-244)
Supplier:
Biolegend
Description:
CD3 Monoclonal Antibody, host: Mouse, Clone: SK7, Reactivity: Human, Isotype: IgG1, K, Conjugate: PerCP/Cyanine5.5, Formulation: Phosphate-buffered solution, Storage: should be stored undiluted between 2deg C and 8deg C and, Application: FC, Synonyms: T3, CD3E, Size: 500 uL
Catalog Number:
(89323-940)
Supplier:
Genetex
Description:
Purity: Purified by antigen-affinity chromatography. Species Reactivity: Human Tested Applications: IHC-P, WB Pkg Size: 100 ul
Catalog Number:
(76522-050)
Supplier:
Biolegend
Description:
Cd226, Monoclonal Antibody, Host: Mouse, Clone: 11A8, Species: Human, African Green, Baboon, Cynomolgus, Rhesus, Isotype: Mouse Igg1, Kappa, Conjugate: Brilliant Violet 605, Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA, Application: FC - Quality tested, Size: 100 Test
Catalog Number:
(10358-150)
Supplier:
Bioss
Description:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Catalog Number:
(RL606-101-129)
Supplier:
Rockland Immunochemical
Description:
Secondary Goat Anti-IgG (H&L) Reacts with Guinea Pig
Catalog Number:
(10392-376)
Supplier:
Bioss
Description:
Glycerol kinase catalyzes the formation of glycerol 3 phosphate from ATP and glycerol. Dihydroxyacetone and L glyceraldehyde can also act as acceptors; UTP and, in the case of the yeast enzyme, ITP and GTP can act as donors. It provides a way for glycerol derived from fats or glycerides to enter the glycolytic pathway.
Catalog Number:
(O-1455.0001BA)
Supplier:
Bachem Americas
Description:
Sequence: 1,2-Dilauroyl-sn-glycero-3-phosphocholine
Synonym(s): DLPC#L-β,γ-Dilauroyl-α-lecithin
Catalog Number:
(76079-856)
Supplier:
Bioss
Description:
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
Catalog Number:
(10361-760)
Supplier:
Bioss
Description:
Tyrosine-protein kinase receptor whose role is not yet clear. ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Catalog Number:
(76422-714)
Supplier:
Biolegend
Description:
CD11b Monoclonal Antibody, Clone: M1/70, Host: Rat, Species reactivity: Chimpanzee, Baboon, Cynomolgus, Isotype: IgG2b, K, Conjugate: TotalSeq B0014, Immunogen: C57BL/10 splenocytes, Formulation: Phosphate-buffered solution, Synonyms: AM integrin, Mac-1, Mo1, Application: FC, Size: 10 ug
Catalog Number:
(10229-614)
Supplier:
Bioss
Description:
Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
Catalog Number:
(10229-820)
Supplier:
Bioss
Description:
Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
Supplier:
Biolegend
Description:
CD3, Monoclonal Antibody, Clone: SK7, Host: Mouse, Species Reactivity: Human, Cross-Reactivity: Chimpanzee, Isotype: IgG1, Conjugate: Spark Blue 550, Other Names: T3, CD3E, Formulation: Phosphate-buffered solution, pH 7.2, 0.09% sodium azide and 0.2% (w/v) BSA, Size: 25 Tests
Catalog Number:
(76422-654)
Supplier:
Biolegend
Description:
CD20, Monoclonal Antibody, Clone: SA271G2, Host: Rat, Species Reactivity: Mouse, Isotype: IgG2b, K, Conjugate: APC, Immunogen: Mouse CD20 transfected cells, Other Names: Ms4a1, Ly-44, Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide, Size: 25 uG
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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