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2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde
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2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde
Catalog Number:
(76078-726)
Supplier:
Bioss
Description:
DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both <i>in vivo</i> and <i>in vitro</i>. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
Catalog Number:
(IC15255405)
Supplier:
MP Biomedicals
Description:
Phenol Red Sodium Salt is used as a pH indicator, it is used widely in culture media to identify changes from neutral to acidic pH values.
Supplier:
Adipogen
Description:
2-heptyl-3-hydroxy-4-quinolone can function as an intercellular signal. Quorum sensing-regulated virulence factor used to induce and study the regulation of virulence genes such as those involved in iron scavenging. Quorum sensing is a signaling system used by bacteria to coordinate activity based upon their population density. The system involves the exchange of signaling molecules among bacteria via cell receptors.
Supplier:
AMBEED, INC
Description:
4-Methoxybenzhydrol 98%
Supplier:
Adipogen
Description:
Keto acid that is involved in the tyrosine catabolism pathway. It is a product of the enzyme (R)-4-hydroxyphenyllactate dehydrogenase and is formed during tyrosine metabolism. The conversion from tyrosine to 4-HPPA is catalyzed by tyrosine aminotransferase. 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment. A deficiency in the catalytic activity of HPD is known to lead to tyrosinemia type III, an autosomal recessive disorder characterized by elevated levels of blood tyrosine and massive excretion of tyrosine derivatives into urine.
Supplier:
MP Biomedicals
Description:
Dimethyl Pimelimidate Dihydrochloride is a bifunctional cross linking reagent used in peptide research.
Catalog Number:
(IC10247101)
Supplier:
MP Biomedicals
Description:
p-Nitrophenyl-alpha-D-galactopyranoside is used as a substrate for α-galactosidase.
Supplier:
MP Biomedicals
Description:
Acrylamide is a monomer used in a variety of synthetic processes to form polymers and copolymers. It polymerizes in the presence of free radicals in aqueous solutions. It is usually used to prepare polyacrylamide gels for electrophoresis separation of biomolecules.
Supplier:
AMBEED, INC
Description:
ω-Bromo-2-chloroacetophenone 98%
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
ω-Bromo-4-methylacetophenone 97%
Supplier:
VWR
Description:
3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), Ultrapure
Supplier:
AMBEED, INC
Description:
2-Bromo-N,N-dimethylaniline 97%
Catalog Number:
(76009-392)
Supplier:
Prosci
Description:
DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
Supplier:
MP Biomedicals
Description:
Butylated Hydroxyanisole is an antioxidant. It is a mixture of 2- and 3-tertiary-butyl-4-hydroxyanisole.
Supplier:
AMBEED, INC
Description:
6-Bromo-3-hydroxyquinoline 98%
Supplier:
MP Biomedicals
Description:
2-Hydroxypropyl-beta-cyclodextrin are non-toxic solubilisers. The solubility of drugs increases linearly with the concentration of 2-Hydroxypropyl-b-cyclodextrin in aqueous buffer. The formation of drug/cyclodextrin complexes is a rapidly reversible reaction and complexes exist both in solution and crystalline states.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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