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Fmoc-D-Lys(Fmoc)-OH
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Fmoc-D-Lys(Fmoc)-OH
Catalog Number:
(10102-718)
Supplier:
Prosci
Description:
CHFR is an E3 ubiquitin-protein ligase required to transiently arrest cells in early prophase when they are exposed to microtubule poisons. It acts in early prophase before chromosome condensation, when the centrosome moves apart from each other along the periphery of the nucleus. CHFR probably promotes the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress. This suggests that it may be involved in signaling the presence of mitotic stress caused by microtubule poisons.
Catalog Number:
(10448-906)
Supplier:
Bioss
Description:
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. Sequence similarities Belongs to the histone-lysine methyltransferase family. EZ subfamily.Contains 1 SET domain.
Catalog Number:
(76084-436)
Supplier:
Bioss
Description:
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.
Catalog Number:
(103623-944)
Supplier:
Sino Biological
Description:
A DNA sequence encoding the human S100A4 (NP_002952.1) (Met 1-Lys 101) was expressed with the fused Fc region of human IgG1 at the N-terminus.
Catalog Number:
(103621-142)
Supplier:
Sino Biological
Description:
A DNA sequence encoding the extracellular domain of human IL20Rα isoform 1 (NP_055247.3) (Met 1-Lys 250) was fused with a polyhistidine tag at the C-terminus.
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Biotinylated Human Angiopoietin-2 / ANGPT2 Protein, His,Avitagâ„¢, ACROBiosystems
Catalog Number:
(76084-438)
Supplier:
Bioss
Description:
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.
Catalog Number:
(103621-714)
Supplier:
Sino Biological
Description:
A DNA sequence encoding the native human S100A13 (NP_001019381.1) (Met 1-Lys 98) was expressed.
Catalog Number:
(77440-308)
Supplier:
Bioss
Description:
Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.
Catalog Number:
(77440-346)
Supplier:
Bioss
Description:
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
Catalog Number:
(103009-890)
Supplier:
Anaspec Inc
Description:
This peptide is histone H4 (1-25) with acetylation at Lys5. It is biotinylated through a C-terminal GSGSK linker. Acetylation at Lys5 plays a role in histone deposition and transcriptional activation. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Sequence:SGRG-K(Ac)-GGKGLGKGGAKRHRKVLRDN-GSGSK(Biotin) MW:3274.8 Da % peak area by HPLC:95 Storage condition:-20° C
Catalog Number:
(103622-532)
Supplier:
Sino Biological
Description:
A DNA sequence encoding the mature form of human IL1F6 (Q9UHA7) (Lys 6-Phe158) was expressed with a polyhistide tag at the N-terminus.
Catalog Number:
(103623-962)
Supplier:
Sino Biological
Description:
A DNA sequence encoding the human Decorin (NP_001911.1) (Met 1-Lys 359) was expressed, with a polyhistidine tag at the C-terminus.
Catalog Number:
(103659-454)
Supplier:
Sino Biological
Description:
Produced in rabbits immunized with purified, recombinant Mouse P4HB (rM P4HB; Catalog#50638-M08H; NP_035162.1; Met 1-Lys 506). Total IgG was purified by Protein A affinity chromatography.
Catalog Number:
(103009-502)
Supplier:
Anaspec Inc
Description:
This is histone H3 (23-34) trimethylated at Lys27 and biotinylated on the C-terminus through a GGK linker. Trimethylation of Lys27 promotes Polycomb protein (Pc)-chromatin association. This modification has also been shown to be associated with methylated CpG island genes in cancer cells. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Sequence:KAAR-K(Me3)-SAPATGG-GGK(Biotin) MW:1624.9 Da % peak area by HPLC:95 Storage condition:-20° C
Catalog Number:
(103623-104)
Supplier:
Sino Biological
Description:
A DNA sequence encoding the human IgG3 Fc region (P01860) (Glu 99-Lys 377) was expressed and purified.
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