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GSK-2334470
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GSK-2334470
Supplier:
AMBEED, INC
Description:
4-(4-(5-(5-Chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl)-1H-indol-1-yl)butanoic acid, Purity: 97%, CAS Number: 1034688-30-6, Appearance: White to Yellow Solid, Storage: Sealed in dry, 2-8C, Size: 5MG
Supplier:
AMBEED, INC
Description:
Tert-butyl 2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate, Purity: 98+%, CAS Number: 1216744-19-2, Appearance: Solid, Storage: Keep in dark place, Sealed in dry, 2-8 C, Size: 5mg
Catalog Number:
(76709-332)
Supplier:
AFG BIOSCIENCE LLC
Description:
Rat Glycogen Synthase(GSK) ELISA Kit
Catalog Number:
(76711-630)
Supplier:
AFG BIOSCIENCE LLC
Description:
Human Glycogen Synthase Kinase 3(GSK-3) ELISA Kit
Catalog Number:
(101777-840)
Catalog Number:
(77218-782)
Supplier:
ANTIBODIES.COM LLC
Description:
Rabbit polyclonal antibody to GSK3 alpha + GSK beta for IHC with samples derived from Human and Mouse.
Supplier:
Enzo Life Sciences
Description:
Glycogen Synthase Kinase 3β (GSK-3β) is a unique serine/threonine kinase that is inactivated by phosphorylation. In response to insulin binding, PKB/AKT phosphorylates GSK-3β on serine 9, which prevents GSK-3β from phosphorylating glycogen synthase. Unphosphorylated glycogen synthase is active and able to synthesize glycogen. GSK-3β is also unique in that it requires a substrate that has been phosphorylated by a distinct kinase before it can phosphorylate the substrate. This phosphate priming mechanism explains why phosphorylation of serine 9 inactivates GSK-3β. The phosphorylated serine binds to the GSK-3β priming phosphate position and prevents binding of alternative substrates. In addition to insulin signaling, GSK-3β participates in the Wnt signaling pathway, where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein. In the presence of Wnts, GSK-3β is unable to phosphorylate beta-catenin, which leads to stabilization of beta-catenin. The Wnt pathway inactivates GSK-3β via the proteins, Dishevelled and FRAT, which disrupt the interaction of GSK-3β with axin, beta-catenin, and APC. Clinically, there is considerable interest in GSK-3β inhibitors because they may mimic the effect of insulin or reduce the hyperphosphorylation of Tau that is observed in Alzheimer's Disease.
Catalog Number:
(10229-080)
Supplier:
Bioss
Description:
The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Catalog Number:
(76083-580)
Supplier:
Bioss
Description:
Glycogen synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase. GSK3 has been implicated in fundamental cell processes such as cell fate determination, metabolism, transcriptional control and oncogenesis. Two isoforms, alpha (GSK3A; OMIM 606784) and beta, show a high degree of amino acid homology within their catalytic domains. GSK3B is involved in energy metabolism, neuronal cell development and body pattern formation.
Supplier:
Enzo Life Sciences
Description:
GSK-3beta inhibitor
Supplier:
AMBEED, INC
Description:
2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate, Purity: 98%, CAS Number: 1579965-12-0, Appearance: Solid, Storage: Keep in dark place, Sealed in dry, 2-8 C, Size: 1mg
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
CHIR 99021 is an aminopyrimidine derivate that is a selective and potent inhibitor of glycogen synthase kinase 3 (GSK-3)
Catalog Number:
(77116-072)
Supplier:
AMBEED, INC
Description:
N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide, Purity: 98+%, CAS Number: 1346572-63-1, Appearance: White to off-white powder or crystals, Storage: Sealed in dry, Room Temperature, Size: 5mg
Catalog Number:
(10229-074)
Supplier:
Bioss
Description:
The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Supplier:
AMBEED, INC
Description:
1-(5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoroindolin-1-yl)-2-(6-methylpyridin-2-yl)ethanone, Purity: 98%, CAS Number: 1337532-29-2, Appearance: White to Yellow to Brown Solid, Storage: Keep in dark place, Inert atmosphere, Store in freezer, under -20 C, Size: 5mg
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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