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Catalog Number:
(76082-122)
Supplier:
Bioss
Description:
IKK beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.
Catalog Number:
(77550-048)
Supplier:
AMBEED, INC
Description:
trans-β-Methylstyrene ≥97% stabilized
Catalog Number:
(10414-982)
Supplier:
Bioss
Description:
IKK beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.
Supplier:
Rockland Immunochemical
Description:
Recombinant Mouse RELM beta control protein
Catalog Number:
(10332-592)
Supplier:
Bioss
Description:
Membrane Receptors Transforming growth factor beta is a multifunctional cytokine known to modulate several tissue development and repair processes, including cell differentiation, cell cycle progression, cellular migration, adhesion, and extracellular matrix production. There are 3 forms encoded by separate genes TGFB1, TGFB2, and TGFB3. The diverse effects of TGF beta are mediated by the TGF beta receptors and cell surface binding proteins. In addition to type I TGF beta receptor (TGFBR1) and type II (TFGBR2), type III (TGF beta III receptor) has been identified. It is a glycoprotein that binds TGF beta and exists in both a membrane bound and a soluble form. It may serve as a receptor accessory molecule in both the TGF beta and fibroblast growth factor systems. TGF beta III receptor lacks a recognizable signaling domain and has no clearly defined role in TGF beta signaling. Endothelial cells undergoing epithelial mesenchymal transformation express TGF beta III receptor, and TGF beta III receptor specific antisera inhibits mesenchyme formation and migration. Misexpression of TGF beta III receptor in nontransforming ventricular endothelial cells conferrs transformation in response to TGFB2. These results support a model where TGF beta III receptor localizes transformation in the heart and plays an essential, nonredundant role in TGF beta signaling. TGF beta III receptor, or beta glycan, can function as an inhibin coreceptor with ActRII. TGF beta III receptor binds inhibin with high affinity and enhances binding in cells coexpressing ActRII and TGF beta III receptor. Inhibin forms crosslinked complexes with both recombinant and endogenously expressed TGF beta III receptor and ActRII. TGF beta III receptor confers inhibin sensitivity to cell lines that otherwise respond poorly to this hormone.
Supplier:
TCI America
Description:
CAS Number: 13035-61-5
MDL Number: MFCD00005358 Molecular Formula: C13H18O9 Molecular Weight: 318.28 Purity/Analysis Method: >98.0% (GC) Form: Crystal Color: White Melting point (°C): 83 Specific rotation [a]20/D: -14.5 deg (C=5, MeOH)
Catalog Number:
(10415-808)
Supplier:
Bioss
Description:
IKK beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.
Supplier:
Thermo Scientific Chemicals
Description:
Beta-D-Gentiobiose, Purity: 98%, CAS number: 554-91-6, Molecular Formula: C12H22O11, Color: White to off White, Form:Powder, Synonyms: 6-O-(beta-D-Glucopyranosyl)-D-glucopyranoseAmygdalose, Size: 100mg
Catalog Number:
(76237-194)
Supplier:
Rockland Immunochemical
Description:
Rat TGF beta 1 AccuSignal ELISA Kit
Catalog Number:
(75790-178)
Supplier:
Prosci
Description:
Transforming Growth Factor beta -1 (TGF beta -1) is a secreted protein which belongs to the TGF- beta family. TGF beta -1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGF beta -1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGF beta -1 peptide. TGF beta -1 may also form heterodimers with other TGF beta family members. It has been found that TGF beta -1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
Catalog Number:
(103331-692)
Supplier:
Novus Biologicals
Description:
The IkB-beta Antibody (1B5) from Novus Biologicals is a mouse monoclonal antibody to IkB-beta. This antibody reacts with human. The IkB-beta Antibody (1B5) has been validated for the following applications: ELISA, Immunohistochemistry-Paraffin.
Catalog Number:
(76236-756)
Supplier:
Rockland Immunochemical
Description:
Human NGF - NGF beta AccuSignal ELISA Kit
Catalog Number:
(103404-804)
Supplier:
Novus Biologicals
Description:
The beta Tubulin Antibody (1B12) [DyLight 550] from Novus Biologicals is a mouse monoclonal antibody to beta Tubulin. This antibody reacts with human, mouse, rat, porcine, bovine. The beta Tubulin Antibody (1B12) [DyLight 550] has been validated for the following applications: Western Blot, Immunocytochemistry / Immunofluorescence.
Catalog Number:
(103286-886)
Supplier:
Novus Biologicals
Description:
The Chorionic Gonadotropin beta Chain (HCG beta) Antibody (HCGb / 459) - IHC-Prediluted from Novus Biologicals is a mouse monoclonal antibody to Chorionic Gonadotropin beta Chain (HCG beta). This antibody reacts with human. The Chorionic Gonadotropin beta Chain (HCG beta) Antibody (HCGb / 459) - IHC-Prediluted has been validated for the following applications: Immunohistochemistry-Paraffin.
Catalog Number:
(10231-152)
Supplier:
Bioss
Description:
Transforming Growth Factor (TGF) betas mediate many cell to cell interactions that occur during embryonic development. Three TGF betas have been identified in mammals. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule. The TGF beta polypeptides are multifunctional; capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed, as well as nonneoplastic tissues, release transforming growth factors; and essentially all mammalian cells possess a specific TGF receptor. The multi modal nature of TGF beta is seen in its ability to stimulate or inhibit cellular proliferation. In general, cells of mesenchymal origin appear to be stimulated by TGF beta whereas cells of epithelial or neuroectodermal origin are inhibited by the peptide. TGF beta 1, TGF beta 2, and TGF beta 1.2 appear to be equivalent in biological activity, although there does appear to be differences in binding to certain types of receptors. TGF beta 2 is produced by many cell types and has been found in the highest concentration in porcine platelets and mammalian bone. Latent TGF beta 2 is the prominent isoform found in body fluids such as amniotic fluid, breast milk, and the aqueous and vitreous humor of the eye.
Catalog Number:
(10414-980)
Supplier:
Bioss
Description:
IKK beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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