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Methyl+laurate
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Methyl+laurate
Catalog Number:
(10288-546)
Supplier:
Bioss
Description:
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
Catalog Number:
(10463-384)
Supplier:
Bioss
Description:
REM (Rad and Gem related GTP binding protein) is a member of the Rad/Gem/Kir subfamily of Ras-like GTPases and shares with other members of this subfamily some unusual structural features. Among these are nonconservative amino acid substitutions within guanine nucleotide binding and hydrolysis domains, unique effector domains, extended N- and C-termini, and a conserved C-terminal sequence thought to mediate membrane association but lacking a classical isoprenylation motif. REM, with a predicted molecular weight of 32.9 kDa, is most highly expressed in cardiac muscle and is expressed at more moderate levels in lung, kidney and skeletal muscle. REM is phosphorylated in vivo and has been shown to interact with several 14-3-3 isoforms. It has been reported that the GTP-bound form of a related Ras-like GTPase, GEM/kir, inhibits high-voltage activated Ca2+ channel activities by interacting directly with the ?subunit. The reduced channel activities are the result of a decreased a-subunit expression at the plasma membrane. This inhibition of L-type Ca2+ channels prevents Ca2+-triggered exocytosis in hormone-secreting cells. There are data that suggest that REM similarly regulates Ca2+ channel expression.
Catalog Number:
(103285-240)
Supplier:
Novus Biologicals
Description:
The ARHGEF38 Antibody from Novus Biologicals is a rabbit polyclonal antibody to ARHGEF38. This antibody reacts with human. The ARHGEF38 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.
Catalog Number:
(103327-338)
Supplier:
Novus Biologicals
Description:
The GNAQ Antibody from Novus Biologicals is a mouse polyclonal antibody to GNAQ. This antibody reacts with human. The GNAQ Antibody has been validated for the following applications: Western Blot.
Catalog Number:
(103278-182)
Supplier:
Novus Biologicals
Description:
The ARHGEF33 Antibody from Novus Biologicals is a rabbit polyclonal antibody to ARHGEF33. This antibody reacts with human. The ARHGEF33 Antibody has been validated for the following applications: Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.
Catalog Number:
(103275-042)
Supplier:
Novus Biologicals
Description:
The ARFGEF2 Antibody from Novus Biologicals is a rabbit polyclonal antibody to ARFGEF2. This antibody reacts with human. The ARFGEF2 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.
Catalog Number:
(103272-884)
Supplier:
Novus Biologicals
Description:
The VAV2 Antibody from Novus Biologicals is a rabbit polyclonal antibody to VAV2. This antibody reacts with human. The VAV2 Antibody has been validated for the following applications: Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.
Catalog Number:
(103270-814)
Supplier:
Novus Biologicals
Description:
The TEM4 Antibody from Novus Biologicals is a rabbit polyclonal antibody to TEM4. This antibody reacts with human. The TEM4 Antibody has been validated for the following applications: Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.
Catalog Number:
(103259-124)
Supplier:
Novus Biologicals
Description:
The ARHGEF16 Antibody from Novus Biologicals is a rabbit polyclonal antibody to ARHGEF16. This antibody reacts with human. The ARHGEF16 Antibody has been validated for the following applications: Immunohistochemistry, Immunohistochemistry-Paraffin.
Catalog Number:
(103286-360)
Supplier:
Novus Biologicals
Description:
The HERC1 Antibody from Novus Biologicals is a rabbit polyclonal antibody to HERC1. This antibody reacts with human. The HERC1 Antibody has been validated for the following applications: Immunohistochemistry, Immunohistochemistry-Paraffin.
Catalog Number:
(103259-120)
Supplier:
Novus Biologicals
Description:
The ARHGEF5 Antibody from Novus Biologicals is a rabbit polyclonal antibody to ARHGEF5. This antibody reacts with human. The ARHGEF5 Antibody has been validated for the following applications: Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.
Catalog Number:
(103270-280)
Supplier:
Novus Biologicals
Description:
The RASGRP2 Antibody from Novus Biologicals is a rabbit polyclonal antibody to RASGRP2. This antibody reacts with human. The RASGRP2 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.
Catalog Number:
(103341-808)
Supplier:
Novus Biologicals
Description:
The RASGRP3 Antibody (1H4) from Novus Biologicals is a mouse monoclonal antibody to RASGRP3. This antibody reacts with human. The RASGRP3 Antibody (1H4) has been validated for the following applications: ELISA.
Catalog Number:
(103286-120)
Supplier:
Novus Biologicals
Description:
The PLEKHG2 Antibody from Novus Biologicals is a rabbit polyclonal antibody to PLEKHG2. This antibody reacts with human. The PLEKHG2 Antibody has been validated for the following applications: Immunohistochemistry, Immunohistochemistry-Paraffin.
Catalog Number:
(103272-660)
Supplier:
Novus Biologicals
Description:
The RAB3IL1 Antibody from Novus Biologicals is a rabbit polyclonal antibody to RAB3IL1. This antibody reacts with human. The RAB3IL1 Antibody has been validated for the following applications: Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.
Catalog Number:
(103287-136)
Supplier:
Novus Biologicals
Description:
The C9orf100 Antibody from Novus Biologicals is a rabbit polyclonal antibody to C9orf100. This antibody reacts with human. The C9orf100 Antibody has been validated for the following applications: Immunohistochemistry, Immunohistochemistry-Paraffin.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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