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Ethephon(2-chloroethylphosphonic+acid)
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Ethephon(2-chloroethylphosphonic+acid)
Supplier:
BeanTown Chemical
Description:
CAS: 302-84-1; EC No: 206-130-6; MDL No: MFCD00064223
Crystalline; Molecular Formula: C3H7NO3 ; MW: 105.09
Melting Point: 240° (decomposes)
Catalog Number:
(10337-786)
Supplier:
Bioss
Description:
Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins.
Catalog Number:
(10337-792)
Supplier:
Bioss
Description:
Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins.
Supplier:
TCI America
Description:
CAS Number: 56-45-1
MDL Number: MFCD00064224 Molecular Formula: C3H7NO3 Molecular Weight: 105.09 Purity/Analysis Method: >99.0% (T) Form: Crystal Color: White Melting point (°C): 228 Specific rotation [a]20/D: 15 deg (C=10, HCl(1+5))
Catalog Number:
(10814-450)
Supplier:
Thermo Scientific Chemicals
Description:
CAS No.: 91037-75-1
Molecular Formula: C22H37N9O10 Formula Weight: 587.58 Storage Temperature: -30°C to -10°C Physical Form: Solid Appearance: White to off-white MDL No.: MFCD00076460
Catalog Number:
(10075-698)
Supplier:
Prosci
Description:
Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002). Ser 549 along with Ser 62 and Ser 67 are the sites of synapsin I that are phosphorylated by MAP kinase (Jovanovic et al., 1996). Phosphorylation and subsequent dephosphorylation of this site is thought to play a key role in synaptic vesicle trafficking.
Catalog Number:
(B-4270.0005BA)
Supplier:
Bachem Americas
Description:
These dipeptide building blocks containing Ser- or Thr-derived oxazolidines (pseudoprolines) proved to be versatile tools for overcoming some intrinsic problems in the field of peptide chemistry. The presence of pseudoprolines within a peptide sequence results in the disruption of β-sheet structures considered as a source of intermolecular aggregation during chain elongation, thus increasing solvation and coupling kinetics in peptide assembly. Therefore, use of pseudoprolines offer new possibilities for accessing large peptides by convergent strategies and chemoselective ligation techniques. Moreover, incorporation of a pseudoproline unit facilitates cyclization of peptides.
Catalog Number:
(103624-246)
Supplier:
Sino Biological
Description:
A DNA sequence encoding the human SORCS1 (Q8WY21-1) extracellular domain (Ser 111-Ser 1099) was fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus
Catalog Number:
(TCM1861-5G)
Supplier:
TCI America
Description:
CAS Number: 6384-08-3
MDL Number: MFCD00171677 Molecular Formula: C6H11NO4 Molecular Weight: 161.16 Purity/Analysis Method: >98.0% (T) Form: Crystal Melting point (°C): 145 Specific rotation [a]20/D: 35 deg (C=2, H2O)
Catalog Number:
(77440-494)
Supplier:
Bioss
Description:
Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.
Supplier:
TCI America
Description:
CAS Number: 14907-27-8
MDL Number: MFCD00038992 Molecular Formula: C12H14N2O2 Molecular Weight: 254.71 Purity/Analysis Method: >98.0% (N) Form: Crystal Color: White Melting point (°C): 205 Specific rotation [a]20/D: -19 deg (C=5, MeOH)
Supplier:
BeanTown Chemical
Description:
CAS: 4931-66-2; EC No: 225-567-3; MDL No: MFCD00080931
Liquid; Molecular Formula: C6H9NO3; MW: 143.14
Boiling Point: 90°/0.3 mmHg; Flash point: <gt/>110°C (<gt/>230°F)
Density (g/mL): 1.226; Refractive Index: 1.486; Optical Rotation: [α]20/D +10.5°, c = 1 in ethanol
Catalog Number:
(77436-830)
Supplier:
Bioss
Description:
AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development. Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD stimulates its pro-apoptotic activity.
Supplier:
Bachem Americas
Description:
Heavy isotope-labeled human pTH (1-34) (Teriparatide) useful for pharmacokinetic/pharmacodynamic studies in combination with Bachem product H-4835 pTH (1-34) (human) or the corresponding generic API.
Catalog Number:
(10337-784)
Supplier:
Bioss
Description:
Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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