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H-Phe(2,5-DiCl)-OH
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H-Phe(2,5-DiCl)-OH
Catalog Number:
(E-2235.0005BA)
Supplier:
Bachem Americas
Description:
Sequence: H-Phe-NHâ‚‚
Catalog Number:
(89359-538)
Supplier:
Genetex
Description:
Estrogen-related receptor alpha (ERR alpha), a NR3 Steroid Receptor, was isolated based on sequence similarity in its DNA-binding domain to estrogen receptor alpha (ER alpha). ERR alpha has been shown to regulate the promoters of lactoferrin, medium-chain acyl CoA dehydrogenase, osteopontin, and thyroid receptor alpha, and it may affect cellular energy balance and bone formation. ERR alpha binds as a monodimer to the extended half-site TNAAGGTCA and as a homodimer to the estrogen response element (ERE) and is a constitutive activator of the estrogen response element and the palindromic thyroid hormone response element (TRE(pal)) but not of the glucocorticoid response element (GRE). ERR alpha 1 is the major isoform expressed in human breast cancer cell lines. Recent studies have shown that Phe-329 is responsible for the constitutive activity of ERR alpha. ERR alpha is a potential biomarker for unfavorable clinical outcome and, possibly, hormonal insensitivity in breast tumors. ERR alpha status may be predictive of sensitivity to hormonal blockade therapy, and ERR alpha status may also be predictive of ErbB2-based therapy such as Herceptin. Moreover, ERR alpha may be a candidate target for therapeutic development. ERRalpha null mice have altered regulation of genes involved in adipogenesis.In mouse, ERR alpha is expressed in many adult and embryonic tissues (particularly at the onset of ossification) as well as in several osteoblast cell lines. ERR alpha expression has been documented in mouse in brain, spinal cord, pituitary gland, heart, intestine, bone, brown adipose tissue, heart, uterus, cervix, nerve, skeletal muscle, and vagina. ESTs have been isolated from human tissue libraries, including cancerous blood, brain, breast, cervix, colon, duodenum, eye, head/neck, kidney, liver, lung, ovary, pancreas, skeletal muscle, skin, stomach, and uterus, and normal adrenal, blood, brain, colon, embryo, eye, head/neck, heart, kidney, prostate, skeletal muscle, testis, and uterus. The ligands for ERR alpha are PPARgamma coactivator 1 (PGC-1) beta and flavone and isoflavone phytoestrogens.
Supplier:
Bachem Americas
Description:
Sequence: H-Phe-OBzl · HCl
Supplier:
AMBEED, INC
Description:
(S)-Ethyl 2-amino-3-(4-fluorophenyl)propanoate hydrochloride, Purity: 97%, CAS Number: 1534-90-3, Appearance: White to off-white solid, Storage: Inert atmosphere, Room Temperature, Size: 1g
Supplier:
Bachem Americas
Description:
Sequence: Suc-Ala-Phe-Pro-Phe-pNA
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 054762-1G , MDL Number:
Catalog Number:
(L-1355.0005BA)
Supplier:
Bachem Americas
Description:
Sequence: H-Phe-pNA
Supplier:
AMBEED, INC
Description:
(R)-Ethyl 2-amino-3-phenylpropanoate hydrochloride, Purity: 98%, CAS Number: 63060-94-6, Appearance: White to Yellow Solid, Storage: Inert atmosphere, Room Temperature, Size: 25g
Catalog Number:
(F-4080.0025BA)
Supplier:
Bachem Americas
Description:
Sequence: H-4-Nitro-Phe-OEt · HCl
Supplier:
Bachem Americas
Description:
Suc-FLF-MNA is a substrate for chymotrypsin and Lon proteases as E.coli protease La.
Supplier:
Bachem Americas
Description:
Sequence: Suc-Phe-Leu-Phe-SBzl
Supplier:
ALADDIN SCIENTIFIC
Description:
Ala-Phe
Supplier:
Bachem Americas
Description:
Sequence: H-Phe-OMe · HCl
Supplier:
AMBEED, INC
Description:
L-Phenylalaninamide hydrochloride 98%
Catalog Number:
(J-1060.0050BA)
Supplier:
Bachem Americas
Description:
Bz-RGFFL-MNA, substrate for cathepsin D.
Supplier:
Spectrum Chemicals
Description:
L-Glutamic Acid, FCC - The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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