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H-d-Ser(tBu)-OMe\u00B7HCl
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H-d-Ser(tBu)-OMe\u00B7HCl
Catalog Number:
(103659-624)
Supplier:
Sino Biological
Description:
Produced in rabbits immunized with purified, recombinant Mouse Epcr / PROCR (rM Epcr / PROCR; Catalog#50874-M08H; Q64695; Met 1-Ser 214). Total IgG was purified by Protein A affinity chromatography.
Catalog Number:
(10417-746)
Supplier:
Bioss
Description:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4.
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Human latent GDF-8 Protein, His Tag, Source: expressed from HEK293. It contains AA Asn 24 - Ser 375, Predicted N-terminus: His, protein carries a polyhistidine tag at the N-terminus, Synonyms: latent GDF-8, GDF-8, Myostatin, GDF8, MSTN, Growth/differentiation factor 8, Size: 500uG
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Human CD27 Ligand/CD70 Protein, His, Flag Tag active trimer (MALS verified), FITC-Labeled, Source: expressed from human 293 cells (HEK293). It contains AA Ser 52 - Pro 193, Predicted N-terminus: His, Synonyms: CD70, CD27LG, TNFSF7, TNFSF7G, CD27L, Size: 200uG
Catalog Number:
(103888-078)
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Human Coagulation Factor III/Tissue Factor Protein, His Tag (MALS verified), Source: expressed from human 293 cells (HEK293), Predicted N-terminus: Ser 33, protein carries a polyhistidine tag at the C-terminus, Synonyms: Coagulation Factor III, Tissue Factor, TF, F3, CD142, Size: 100uG
Catalog Number:
(10347-764)
Supplier:
Bioss
Description:
Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.
Catalog Number:
(10472-012)
Supplier:
Bioss
Description:
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.Tissue specificity: Highly expressed in testis and thymus. Expressed also in most cancer cells lines.
Catalog Number:
(10472-010)
Supplier:
Bioss
Description:
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.Tissue specificity: Highly expressed in testis and thymus. Expressed also in most cancer cells lines.
Supplier:
Bachem Americas
Description:
Sensitive internally quenched fluorogenic (FRET) substrate for SARS main protease with a Km value of 17 µM and a kcat value of 1.9 s⁻¹.
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Human TREM2 Protein, Mouse IgG2a Fc Tag, Source: expressed from HEK293. It contains AA His 19 - Ser 174, Predicted N-terminus: His 19, protein carries a mouse IgG2a Fc tag at the C-terminus, Synonyms: Triggering receptor, Source: expressed on myeloid cells 2/TREM2/TREM-2, Size: 100uG
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Human ACE2/ACEH Protein, His, Avitag* (MALS verified), Biotinylated, Source: expressed from human 293 cells (HEK293). It contains AA Gln 18 - Ser 740, Predicted N-terminus: Gln 18, protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag, Synonyms: ACE-2, ACEH, ACE2, Size: 200uG
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Human HGF Protein, His Tag (MALS verified), Source: expressed from human 293 cells (HEK293). It contains AA Gln 32 - Ser 728, Predicted N-terminus: Gln 32, Molecular weight: 81.6 kDa (A chain 53.7 kDa and B chain 27.9 kDa), Synonyms: HGF, HPTA, SF, Size: 100uG
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Human TREM2 Protein, Fc Tag, Source: expressed from human 293 cells (HEK293). It contains AA His 19 - Ser 174, Predicted N-terminus: His 19, protein carries a human IgG1 Fc tag at the C-terminus, Synonyms: Triggering receptor, Source: expressed on myeloid cells 2/TREM2/TREM-2, Size: 100uG
Supplier:
ACROBIOSYSTEMS INC MS
Description:
SARS-CoV-2 S2 protein (A701V), His Tag, Source: expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus, Predicted N-terminus: Ser 686, Synonyms: Spike, S2 protein, Spike glycoprotein Subunit2, S glycoprotein Subunit2, Size: 100uG
Supplier:
Bachem Americas
Description:
RGDS, a tetrapeptide which supports fibroblast attachment and inhibits fibronectin binding to platelets. RGDS is a target sequence for syphilis spirochete cytadherence.
Catalog Number:
(66014-254)
Supplier:
DWK Life Sciences (KIMBLE)
Description:
This lightweight, economical vial can be used in most standard gas and liquid chromatography autosamplers.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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