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H-d-Ser(tBu)-OMe·HCl
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H-d-Ser(tBu)-OMe·HCl
Catalog Number:
(10412-264)
Supplier:
Bioss
Description:
Chk2 is a serine/threonine kinase involved in the control of cell cycle checkpoints, and may also participate in transduction of the DNA damage and replicational stress signals. Chk2 is the mammalian ortholog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases. The amino-terminal domain of Chk2 contains a series of seven serine and threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases. Indeed, after DNA damage by ionizing radiation (IR), UV irradiation or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributable to autophosphorylation of Chk2 on residues Thr383 and Thr387 in the activation loop of the kinase domain. Chk2 inhibits CDC25C phosphatase by phosphorylating it on Ser-216, preventing the entry into mitosis. This kinase may have a role in meiosis as well. Kinase activity is up regulated by autophosphorylation and the protein is rapidly phosphorylated in response to DNA damage and to replication block.
Catalog Number:
(77692-325)
Supplier:
LGC STANDARDS
Description:
2-Aminoindane Hydrochloride (2-AI HCl) 1.0 mg/ml in Methanol (as free base), LoGiCal, LGC Standards
Catalog Number:
(10423-984)
Supplier:
Bioss
Description:
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.
Supplier:
Bachem Americas
Description:
Please see also α-MSH (corresponds to acetyl-ACTH (1-13) amide, H-1075), α-MSH (free acid) (acetyl-ACTH (1-13), H-1070), and (Des-acetyl)-α-MSH (H-4390). Wied: Pituitary Adrenal System Hormones and Behaviour. Symposium on Developments in Endocrinology (1976) / Anon.: ACTH and Related Peptides: Structure, Regulation, and Action. Ann. N.Y. Acad. Sci. 297, 1 (1977) / A.V.Schally: Aspects of Hypothalamic Regulation of the Pituitary Gland. Science 202, 18 (1978) / R.Schwyzer: Studies on Polypeptide Receptors. A Critical View on the Mechanism of ACTH Action. Bull. Schweiz. Acad. Med. Wiss. 34, 263 (1978).
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 048522-5G , MDL Number: MFCD12827835
Catalog Number:
(10391-390)
Supplier:
Bioss
Description:
Chk2 is a serine/threonine kinase involved in the control of cell cycle checkpoints, and may also participate in transduction of the DNA damage and replicational stress signals. Chk2 is the mammalian ortholog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases. The amino-terminal domain of Chk2 contains a series of seven serine and threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases. Indeed, after DNA damage by ionizing radiation (IR), UV irradiation or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributable to autophosphorylation of Chk2 on residues Thr383 and Thr387 in the activation loop of the kinase domain. Chk2 inhibits CDC25C phosphatase by phosphorylating it on Ser-216, preventing the entry into mitosis. This kinase may have a role in meiosis as well. Kinase activity is up regulated by autophosphorylation and the protein is rapidly phosphorylated in response to DNA damage and to replication block.
Catalog Number:
(77686-058)
Supplier:
AMBEED, INC
Description:
N-Cyclopropyl-N-isopropylamine hydrochloride ≥95%
Supplier:
AMBEED, INC
Description:
2,4-Dichloro-5-fluoropyrimidine, Purity: 98%, CAS number: 2927-71-1, Appearance: White to Yellow to Green Solid or Semi-Solid or Liquid or Lump, Storage: Inert atmosphere, 2-8C, Size: 5G
Supplier:
Thermo Scientific Chemicals
Description:
Molecular Formula: Ga in 5% HNO3/tr. HCl
Physical Form: Liquid UN No.: 3264 MDL No.: MFCD00134045
Catalog Number:
(77976-199)
Supplier:
LGC STANDARDS
Description:
d,l-MDEA-D5.HCl, 1mg/ml in Methanol (as free base), Lipomed, LGC Standards
Catalog Number:
(77697-691)
Supplier:
LGC STANDARDS
Description:
MISA Standard 3: Sb, Sn, Te @ 100 µg/mL in 20% HCl, VHG, LGC Standards
Supplier:
ALADDIN SCIENTIFIC
Description:
Malonamamidine hydrochloride is a useful biochemical for proteomics research.A useful biochemical for proteomics research
Catalog Number:
(10261-096)
Supplier:
Bioss
Description:
SCA11 is a 1,244 amino acid protein that belongs to the protein kinase superfamily and the CK1 Ser/Thr protein kinase family. The SCA11 gene, comprising of 16 exons, produces a 5.6-kb transcript in which the longest open reading frame is 3,732 nucleotides. Defects in the SCA11 protein are the cause of the disorder spinocerebellar ataxia type 11 (SCA11). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. The SCA11 disorder is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder. The SCA11 protein has also been implicated in Alzheimer disease and in tangle formation. Existing as three alternatively spliced isoforms, the SCA11 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken and zebrafish, and maps to human chromosome 15q15.2.
Catalog Number:
(10326-624)
Supplier:
Bioss
Description:
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.
Supplier:
Electron Microscopy Sciences
Description:
Natural, hard gelatin capsules are used as an embedding mold for water miscible resins, or resins which need to be cured by transmitted light. The gelatin capsules dissolve or disintegrate within 5 minutes when immersed in a 0.5% HCl solution at 36 to 38 °C, within 2 minutes in water at 37 °C or in artificial gastric juice.
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is still displayed and you need assistance, please call us at 1-800-932-5000.
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