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H-d-Ser(tBu)-OMe·HCl
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H-d-Ser(tBu)-OMe·HCl
Catalog Number:
(89158-960)
Supplier:
Enzo Life Sciences
Description:
Negative control for cyclopamine.
Catalog Number:
(10796-974)
Supplier:
Prosci
Description:
RAC-alpha serine/threonine-protein kinase (AKT1) is also known PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt and RAC-PK-alpha, which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and RAC subfamily and is expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase).
Supplier:
TLC PHARMACEUTICAL STANDARD LTD
Description:
Pharmaceutical Standards, Calcitonin Salmon Impurity 37 Pentatrifluoroacetate (4-Ser-O-Acetylated Calcitonin (Salmon) Pentatrifluoroacetate)
Catalog Number:
(10417-750)
Supplier:
Bioss
Description:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4.
Catalog Number:
(103656-456)
Supplier:
Sino Biological
Description:
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse LY86 (rM LY86; Catalog#50062-M08H; Met 1-Ser 162; NP_034875.1).
Supplier:
ACROBIOSYSTEMS INC MS
Description:
SARS-CoV-2 (COVID-19) NSP7 Protein, His Tag (MALS verified), ACROBiosystems
Catalog Number:
(10417-748)
Supplier:
Bioss
Description:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4.
Catalog Number:
(103656-978)
Supplier:
Sino Biological
Description:
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL-1 alpha / IL-1F1 / IL1A (rM IL-1 alpha / IL-1F1 / IL1A; Catalog#50114-MNAE; NP_034684.2; Ser 115-Ser 270).
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Human JAB1/COPS5 Protein, Fc Tag, Source: expressed from Baculovirus-Insect cells. It contains AA Ala 2 - Ser 334, Predicted N-terminus: Ala 2, protein carries a human IgG1 Fc tag at the C-terminus, Synonyms: JAB1, Size: 1mg
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
D-(-)-Serine 98%
Catalog Number:
(103888-294)
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Human IL-21 Protein, Tag Free, low endotoxin (HPLC verified), Source: expressed from human 293 cells (HEK293). It contains AA Gln 30 - Ser 162, Predicted N-terminus: Gln 30, protein carries no tag, Synonyms: IL21, Za11, Interleukin-21, Size: 1mg
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
L(+)-Histidine monohydrochloride monohydrate 98.5-101.0%, Multi-Compendial, meets analytical specification of ChP, BP, JP, Ph. Eur., Macron Fine Chemicals™
Catalog Number:
(10081-590)
Supplier:
Proteintech
Description:
Three members of c-Jun N-terminal kinases (JNK), JNK1, JNK2 and JNK3, have been reported, which are distant members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif during response to UV light. JNK1 functions to phosphorylate c-Jun at N-terminal serine regulatory sites of Ser-63 and Ser-73, mapping within the transactivation domain. Phosphorylation of these sites in response to UV results in transcriptional activation of c-Jun.
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Rabbit IL-5 Protein, His Tag, Source: expressed from human 293 cells (HEK293). It contains AA Met 20 - Ser 134, Predicted N-terminus: His, protein carries a polyhistidine tag at the N-terminus, Synonyms: IL-5, TRF, IL5, Interleukin-5, Size: 1mg
Catalog Number:
(103888-158)
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Human IL-15 Protein, Tag Free (SPR verified), Source: expressed from E.coli cells. It contains AA Asn 49 - Ser 162, Predicted N-terminus: Met, protein carries no tag, Synonyms: IL-15, Interleukin-15, MGC9721, Size: 1mg
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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