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N-(4-Fluorophenyl)-4-piperidinecarboxamide+hydrochloride
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N-(4-Fluorophenyl)-4-piperidinecarboxamide+hydrochloride
Supplier:
BeanTown Chemical
Description:
CAS: 141-32-2; EC No: 216-768-7; MDL No: MFCD00009446; RTECS: UD3150000
UN No: UN2348; Haz Class: 3; Packing Group: III
Liquid; Linear Formula: CH2=CHCOO(CH2)3CH3; Molecular Formula: C7H12O2; MW: 128.17
Melting Point: -69°; Boiling Point: 145°; Flash point: 36°C (97°F)
Density (g/mL): 0.894; Refractive Index: 1.418
Light Sensitive
Catalog Number:
(10408-982)
Supplier:
Bioss
Description:
Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs).
Catalog Number:
(10075-420)
Supplier:
Prosci
Description:
Dynamin is a member of a group of nerve terminal proteins called dephosphins that regulate synaptic vesicle endocytosis (Cousin et al., 2001; Graham et al., 2002; Tsuboi et al., 2002). There are 3 known isofoms of Dynamin, each having several splice variants as well. Dynamin I is expressed only in neurons whereas Dynamin II is ubiquitously expressed and Dynamin III is found primarily in the testes. Dynamin 1 is phosphorylated by PKC and dephosphorylated by calcineurin.
Catalog Number:
(10082-228)
Supplier:
Proteintech
Description:
SPHK(Sphingosine kinase 1) is also named as SPHK, SPK.It catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions and is precariously perched at the balance point between progrowth and pro-death signalling in the cell.Endogenous SPHK1 purified from placenta has identical enzymatic characteristics, suggesting posttranslational modification does not effect functional properties.It has 2 isoforms produced by alternative splicing and can form the oligomeric structure.
Catalog Number:
(10343-682)
Supplier:
Bioss
Description:
Sphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430) and serum.[supplied by OMIM].
Supplier:
DWK Life Sciences (KIMBLE)
Description:
Test tubes made from KG-33 borosilicate glass with a [ST] top and a [ST] glass stopper.
Supplier:
BeanTown Chemical
Description:
CAS: 7440-31-5; EC No: 231-141-8; MDL No: MFCD00133862; RTECS: XP7320000
Solid; Molecular Formula: Sn; MW: 118.71
Melting Point: 231.9°; Boiling Point: 2270°
Density (g/mL): 7.31
Supplier:
BeanTown Chemical
Description:
CAS: 1330-20-7; EC No: 215-535-7; MDL No: MFCD00077264; RTECS: ZE2100000
UN No: UN1307; Haz Class: 3; Packing Group: III
Liquid; Linear Formula: C6H4(CH3)2; Molecular Formula: C8H10; MW: 106.17
Melting Point: <lt/>-25°; Boiling Point: 137-140°; Flash point: 25°C (77°F)
Density (g/mL): 0.86; Refractive Index: 1.497
Catalog Number:
(89367-654)
Supplier:
Genetex
Description:
Rabbit polyclonal to NTH1
Supplier:
BeanTown Chemical
Description:
CAS: 3886-70-2; EC No: 223-425-5; MDL No: MFCD00064114
UN No: UN2922; Haz Class: 8 (6.1); Packing Group: III
Liquid; Molecular Formula: C12H13N; MW: 171.24
Boiling Point: 153°/11 mmHg; Flash point: <gt/>110°C (<gt/>230°F)
Density (g/mL): 1.067; Refractive Index: 1.623; Optical Rotation: [α]20/D +55°, c = 2 in ethanol
Air Sensitive
Supplier:
BeanTown Chemical
Description:
CAS: 13472-00-9; EC No: 236-739-2; MDL No: MFCD00008194
UN No: UN3259; Haz Class: 8; Packing Group: III
Liquid/Low Melting Solid; Molecular Formula: C8H12N2; MW: 136.19
Melting Point: 28-31°; Boiling Point: 103°/0.3 mmHg; Flash point: <gt/>110°C (<gt/>230°F)
Density (g/mL): 1.034; Refractive Index: 1.591
Air Sensitive
Supplier:
New England Biolabs (NEB)
Description:
E. coli RecA is necessary for genetic recombination, reactions involving DNA repair and UV-induced mutagenesis. RecA promotes the autodigestion of the lexA repressor, umuD protein and lambda repressor. Cleavage of LexA derepresses more than 20 genes. In vitro studies indicate that in the presence of ATP, RecA promotes the strand exchange of single-strand DNA fragments with homologous duplex DNA. The reaction has three distinct steps: (i) RecA polymerizes on the single-strand DNA, (ii) the nucleoprotein filament binds the duplex DNA and searches for a homologous region, (iii) the strands are exchanged.
Catalog Number:
(77067-256)
Supplier:
ANTIBODIES.COM LLC
Description:
Rabbit polyclonal antibody to CA3 for WB and ELISA with samples derived from Human, Mouse and Rat.
Supplier:
Strem Chemicals Inc
Description:
CAS #: 12266-38-5. Size: 5g.
Catalog Number:
(89355-574)
Supplier:
Genetex
Description:
Goat polyclonal to TGFBR3
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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