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Lead(II)+acetate+trihydrate
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Lead(II)+acetate+trihydrate
Supplier:
Adipogen
Description:
Potent, specific and competitive inhibitor of type II 5alpha-reductase (enzyme which converts testosterone to the more potent 5alpha-dihydrotestosterone). Anticancer compound. Apoptosis modulator. Enhances the action of GABA at GABA(A) receptors, which leads to neurological implications. Inhibit testosterone-induced type I procollagen and TGF-beta1 expression in human scalp dermal fibroblasts in a model of androgenic alopecia. Drug for the treatment of male androgenetic alopecia. Potential role in neuropsychiatric disorders.
Supplier:
BeanTown Chemical
Description:
CAS: 110-19-0; EC No: 203-745-1; MDL No: MFCD00008932; RTECS: AI4022500
UN No: UN1213; Haz Class: 3; Packing Group: II
Liquid; Linear Formula: CH3CO2CH2CH(CH3)2; Molecular Formula: C6H12O2; MW: 116.16
Melting Point: -99°; Boiling Point: 115-117°; Flash point: 18°C (64°F)
Density (g/mL): 0.867; Refractive Index: 1.389
Supplier:
Strem Chemicals Inc
Description:
Acetato(2'-di-t-butylphosphino-1,1'-biphenyl-2-yl)palladium(II) 98
Catalog Number:
(76110-388)
Supplier:
Bioss
Description:
Spo11 is a type II topoisomerase that is thought to generate the chromosome breaks that initiate meiotic recombination. The Spo11 protein initiates meiotic recombination by generating DNA double-strand breaks (DSBs) and is required for meiotic synapsis in S. cerevisiae. The DSBs are located mostly in promoter regions, where the chromatin is in an open configuration, and cluster in domains along the chromosome. Expression of the Spo11 is detected mainly in the testis, in agreement with its predicted function in the initiation of meiotic recombination. Disruption of Spo11 leads to severe gonadal abnormalities from defective meiosis and results in infertility.
Catalog Number:
(75791-310)
Supplier:
Prosci
Description:
IFN gamma is the major interferon produced by mitogenically or antigenically stimulated lymphocytes. It is structurally different from type I interferon and its major activity is immunoregulation. It has been implicated in the expression of class II histocompatibility antigens in cells that do not normally produce them, leading to autoimmune disease. Interferon gamma is produced mainly byT-cells and natural killer cells activated by antigens, mitogens, or alloantigens. It is produced by lymphocytes expressing the surface antigens CD4 and CD8. IFN gamma synthesis is induced by IL-2, FGF-basic, and EGF.
Catalog Number:
(100243-638)
Supplier:
Southern Biotechnology
Description:
Murine CD72.1 (Lyb-2.1), a type II integral membrane glycoprotein and a member of the C-lectin family of cell surface receptors, is a differentiation antigen of B cells and is found in mouse strains expressing the Lyb-2.1 allotype. CD72.1 is the ligand of CD5 which is distributed on all T cells and a small number of B cells. The 10.1.D2 monoclonal antibody blocks binding of CD5 to CD72 on the B cell surface which leads to inhibition of the positive signal resulting from CD5/CD72 pairing. However, 10.1.D2 can itself trigger a positive signal by binding CD72.
Supplier:
BeanTown Chemical
Description:
CAS: 64-19-7; EC No: 200-580-7; MDL No: MFCD00036152
UN No: UN2789; Haz Class: 8 (3); Packing Group: II
Liquid; Linear Formula: CH3CO2H; MW: 60.05
Melting Point: 16.2°; Boiling Point: 117-118°; Flash point: 40°C (104°F)
Density (g/mL): 1.049; Refractive Index: 1.371
Catalog Number:
(10750-934)
Supplier:
Prosci
Description:
PIAS1 Antibody: The PIAS proteins (protein inhibitor of activated STAT) play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS1. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS1 binds specifically to STAT1, inhibiting STAT1-mediated gene activation and also binds to the Gu/RNA helicase II enzyme, leading to the proteolytic cleavage of Gu/RH-II. PIAS1 is a potent co-activator for CP2c-mediated alpha-globin expression in erythroid cells.
Catalog Number:
(10244-350)
Supplier:
Bioss
Description:
Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). [provided by RefSeq, Jul 2008].
Supplier:
BeanTown Chemical
Description:
CAS: 79-20-9; EC No: 201-185-2; MDL No: MFCD00008711; RTECS: AI9100000
UN No: UN1231; Haz Class: 3; Packing Group: II
Liquid; Linear Formula: CH3COOCH3; MW: 74.08
Melting Point: -98°; Boiling Point: 57-58°; Flash point: -13°C (9°F)
Density (g/mL): 0.934; Refractive Index: 1.361
Moisture Sensitive
Catalog Number:
(10750-330)
Supplier:
Prosci
Description:
MARCH8 Antibody: MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.
Supplier:
Thermo Scientific Chemicals
Description:
In ceramics, manufacturing Co compounds, pigments, salts
Supplier:
AMBEED, INC
Description:
Acetato(2'-di-t-butylphosphino-1,1'-biphenyl-2-yl)palladium(II) 98%
Supplier:
BeanTown Chemical
Description:
CAS: 141-78-6; EC No: 205-500-4; MDL No: MFCD00009171; RTECS: AH5425000
UN No: UN1173; Haz Class: 3; Packing Group: II
Liquid; Linear Formula: CH3COOCH2CH3; Molecular Formula: C4H8O2; MW: 88.11
Melting Point: -84°; Boiling Point: 76.5-77.5°; Flash point: -3°C (27°F)
Density (g/mL): 0.902; Refractive Index: 1.372
Supplier:
Elga Labwater
Description:
Ideal water system for a new start up lab. Advanced and affordable, providing tap to Type I water.
Supplier:
Thermo Scientific Chemicals
Description:
Very slightly soluble (with dissociation) in acetone, alcohol, chloroform, ethyl acetate, and toluene
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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