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Loxoprofen+sodium
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Loxoprofen+sodium
Catalog Number:
(10433-842)
Supplier:
Bioss
Description:
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity).
Catalog Number:
(10101-060)
Supplier:
Prosci
Description:
ACCN1 is a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. ACCN1 may play a role in neurotransmission. In addition, a heteromeric association between ACCN1 and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium.
Catalog Number:
(103879-736)
Supplier:
Abnova
Description:
Mouse monoclonal antibody raised against native KLK3.
Catalog Number:
(10364-230)
Supplier:
Bioss
Description:
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013].
Catalog Number:
(10365-998)
Supplier:
Bioss
Description:
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013].
Catalog Number:
(100504-242)
Supplier:
Electron Microscopy Sciences
Description:
Ultrastructural localization sodium. Reference: J. Histochem Cystochem., 24, 740 (1976).
Catalog Number:
(100503-680)
Supplier:
Electron Microscopy Sciences
Description:
Used with picric acid/aniline blue for staining collagen, recticulum, muscle, and plasma. Also Luna's method for erythrocytes & eosinophil granules and Guard's method for sex chromatin and nuclear chromatin.
Catalog Number:
(76003-386)
Supplier:
Enzo Life Sciences
Description:
Produced in E.coli.
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Xylenol orange tetrasodium salt, water soluble, pure
Catalog Number:
(RC5888.43-16)
Supplier:
Ricca Chemical
Description:
Potassium Chloride Conductivity Standard, 5 mS/cm (5000 µmho/cm) at 25 °C, Ricca Chemical Company
Supplier:
IBI Scientific
Description:
Carbenicillin is an antibiotic which inhibits bacterial cell wall synthesis activity against gram-positive and gram-negative bacteria
Supplier:
HiMedia
Description:
William's medium E developed by Williams and Gunn for the isolation and long term maintenance of adult rat liver epithelial cells.
Catalog Number:
(EM1.08122.0025)
Catalog Number:
(75931-194)
Supplier:
Rockland Immunochemical
Description:
Protein A Peroxidase Conjugated
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
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