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Methyl+2-amino-5-(dimethylphosphoryl)benzoate
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Methyl+2-amino-5-(dimethylphosphoryl)benzoate
Supplier:
MP Biomedicals
Description:
Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate has been reported to arrest the cell cycle in late G1/S thus leading to the inhibition of the synthesis of DNA, RNA, thymidylates, and proteins. The main mechanism of action is reported to involve the inhibition of enzymes involved in purine metabolism which leads to the accumulation of adenosine or the suppression of intercellular adhesion molecule expression by T cells. Additionally, this compound has been observed to inhibit DHFR.
Methotrexate is used for chemotherapy either alone or in combination with other agents. It is effective for the treatment of a number of cancers including: breast, head and neck, leukemia, lymphoma, lung, osteosarcoma, bladder, and trophoblastic neoplasms. It is also used in treatment of autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It is used to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites. Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis. Methotrexate is an allosteric inhibititor of dihydrofolate reductase (DHFR), the enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. Since tetrahydrolfolate is required for purine and pyrimidine synthesis, methotrexate treatment results in the inhibition of DNA and RNA synthesis.
Catalog Number:
(101934-732)
Supplier:
Matrix Scientific
Description:
MF=C11H14Cln3Os MW=271.77 ,250Mg
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 058731-5G , MDL Number: MFCD00829075
Supplier:
Matrix Scientific
Description:
MF=C8H10Clf2N5 MW=249.65 Cas=66088-52-6 MDL=MFCD00053015 ,5G
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Bisacrylamide 99+% for biochemistry, for electrophoresis
Supplier:
Strem Chemicals Inc
Description:
Boronic Acid and Ester
Supplier:
AMBEED, INC
Description:
Tozasertib 99+%
Catalog Number:
(76483-132)
Supplier:
AAT BIOQUEST INC
Description:
Calcium measurement is critical for numerous biological investigations.
Catalog Number:
(77686-896)
Supplier:
AMBEED, INC
Description:
Lx1606 98+%
Catalog Number:
(75873-508)
Supplier:
Spectrum Chemicals
Description:
Tetrahydrofolic Acid, Cas number: 135-16-0, Molecular Formula: C19H23N7O6, Molecular Weight: 445.43, Color/Form: Light yellow, brown, Beige solid powder, Synonym: 5,6,7,8-Tetrahydropteroyl-L-glutamic Acid, Tetrahydropteroylglutamic acid, Size: 1GM
Supplier:
AMBEED, INC
Description:
ABT-263 98%
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 042185-1G , MDL Number: MFCD01321022
Supplier:
AMBEED, INC
Description:
(2S,3R)-2-Amino-3-methoxybutanoic acid, Purity: 98%, CAS number: 4144-02-9, Appearance: Form: powder Colour: white - off white, Storage: Keep in dark place, Inert atmosphere, 2-8C, Size: 250MG
Supplier:
BeanTown Chemical
Description:
CAS: 59-05-2; EC No: 200-413-8; MDL No: MFCD00150847; RTECS: MA1225000
UN No: UN1544; Haz Class: 6.1; Packing Group: III
Powder; Molecular Formula: C20H22N8O5; MW: 454.44
Melting Point: 185-204°
Supplier:
Enzo Life Sciences
Description:
Palbociclib, also known as PD0332991, is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.
Supplier:
Enzo Life Sciences
Description:
Nitric oxide (NO) donor.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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