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3,4,5-Trifluorobenzenesulphonyl+chloride
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3,4,5-Trifluorobenzenesulphonyl+chloride
Catalog Number:
(10419-994)
Supplier:
Bioss
Description:
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
Catalog Number:
(10663-938)
Supplier:
Bioss
Description:
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
Catalog Number:
(101933-986)
Supplier:
Matrix Scientific
Description:
MF=C15H21N3O3 MW=291.35 250Mg
Catalog Number:
(76080-866)
Supplier:
Bioss
Description:
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
Catalog Number:
(TCM1763-200MG)
Supplier:
TCI America
Description:
Molecular Weight: 1116.09
Purity/Analysis Method: >97.0% (HPLC) Form: Crystal Storage Temperature: <0°C Molecular Formula: C56H61NO23
Catalog Number:
(103367-970)
Supplier:
Novus Biologicals
Description:
The HIF-2 alpha / EPAS1 Antibody [Alexa Fluor« 647] from Novus Biologicals is a rabbit polyclonal antibody to HIF-2 alpha / EPAS1. This antibody reacts with human, mouse, rat, fish, hamster, primate, sheep. The HIF-2 alpha / EPAS1 Antibody [Alexa Fluor« 647] has been validated for the following applications: Western Blot, Flow Cytometry, ELISA, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen.
Catalog Number:
(89160-282)
Supplier:
Enzo Life Sciences
Description:
Fluor de Lys® Substrate is a highly sensitive and convenient alternative to radiolabeled, acetylated histones or peptide/HPLC methods for the assay of histone deacetylases. The Fluor de Lys® Substrate, which comprises an acetylated lysine side chain, is incubated with a sample containing HDAC activity (nuclear or cellular extract, purified enzyme, bead-bound immunocomplex, etc.). Deacetylation of the substrate sensitizes the substrate so that, in a second step, treatment with the Fluor de Lys® Developer produces a fluorophore. Histone deacetylases from all known classes have been successfully assayed with the Fluor de Lys® Substrate. These include human HDACs 1, 2, 3 and 8 (class I), human HDACs 4 and 9 (class II) and the sirtuins yeast Sir2, human SIRT1 and human SIRT2 (class III; reaction must include the sirtuin substrate NAD+). The substrate is cell-permeable and serves as the basis for the HDAC Cellular Activity Assay Kit (Prod. No. BML-AK503). NOTE: Must be used in conjunction with Fluor de Lys® Developer (Prod. No. BML-KI105). Sufficient for 100-1000 assays of HDACs or sirtuins (50 µl reaction volume, 50-500 µM (substrate).
Catalog Number:
(103230-096)
Supplier:
Novus Biologicals
Description:
Histone H4, Polyclonal Antibody, Host: Sheep, Species Reactivity: Human, Mouse, Isotype: IgG, Immunogen: Tetrahymena pyriformis acetylated Histone H4 synthetic peptideAGGKGGKGMGKVGAKRHSK, Synonyms: H4/A, H4/B, H4/C, H4/D, H4/E, Application: WB, ICC, Size: 25UG
Catalog Number:
(77740-076)
Supplier:
AFG BIOSCIENCE LLC
Description:
15104
Catalog Number:
(77806-235)
Supplier:
AFG BIOSCIENCE LLC
Description:
29147
Catalog Number:
(76485-354)
Supplier:
AAT BIOQUEST INC
Description:
XFD594 is manufactured by AAT Bioquest, and it has the same chemical structure of Alexa Fluor® 594 (Alexa Fluor® is the trademark of ThermoFisher).
Catalog Number:
(10110-150)
Supplier:
Prosci
Description:
NAT6 belongs to the acetyltransferase family. It contains 1 N-acetyltransferase domain. NAT6 seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. It may act as a tumor suppressor. Defects in NAT6 are found in non-small cell lung cancer (NSCLC) cell lines.
Catalog Number:
(75789-122)
Supplier:
Prosci
Description:
Fibroblast Growth Factor 21 (FGF21) is a growth factor that belongs to the FGF family. FGF family proteins play a central role during prenatal development and postnatal growth and regeneration of mamy tissues, by promoting cellular proliferation and differentiation. FGF21 is a potent activator of glucose uptake on adipocytes, protects animal from diet-induced obesity when overexpression in transgenic mice, and lower blood glucose and triglyceride levels when therapeutically adiministered to diabetic redents. FGF21 is produced by hepatocytes in reponse to free fatty acid stimulation of a PPARa/RXR dimeric complex. This situation occurs clinically during starvation, or following the ingestionof a highly-fat/low-carbohydrate diet.Upon FGF21 secretion, white adipose tissue is induced to release free fatty acids from triglyceride stores. Once free fatty acid reach hepatocytes, they are oxidized and reduced to acetyl-CoA. The acetyl-CoA is recombined into 4-carbon ketone bodies, release, and transported to peripheral tissue for TCA processing and energy generation.
Catalog Number:
(TCD0040-025G)
Supplier:
TCI America
Description:
CAS Number: 64039-28-7
MDL Number: MFCD00040583 Molecular Formula: C8H8O4 Molecular Weight: 190.13 Purity/Analysis Method: >98.0% (HPLC,T) Form: Crystal
Catalog Number:
(10104-818)
Supplier:
Prosci
Description:
Adaptor proteins are usually required for transcriptional activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter.TADA3L is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis.Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined.
Catalog Number:
(101933-968)
Supplier:
Matrix Scientific
Description:
MF=C15H21N3O3 MW=291.35 250Mg
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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