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N(α)-Boc-D-tryptophan
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N(α)-Boc-D-tryptophan
Catalog Number:
(10266-644)
Supplier:
Bioss
Description:
SPR, also known as sepiapterin reductase, is a homodimeric cytoplasmic protein that belongs to the sepiapterin reductase family. SPR functions as an NADH-dependent aldo-keto reductase and specifically catalyzes the reduction of pteridine derivatives. In addition, SPR plays an important role in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the final reduction step of the synthesis pathway. BH4 is an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, tyrosine and phenylalanine) and is required for proper dopamine synthesis. Mutations in the gene encoding SPR can cause sepiapterin reductase deficiency, a monoamine neurotransmitter deficiency without hyperphenylalaninemia. Sepiapterin reductase deficiency interferes with BH4 synthesis, resulting in DOPA-responsive dystonia and a variety of other human diseases. In addition, SPR mRNA expression is increased in the brain of Parkinson’s Disease (PD) patients, suggesting that SPR may play a role in PD.
Catalog Number:
(10782-104)
Supplier:
Biosensis
Description:
Tyrosine hydroxylase is an excellent marker for dopaminergic and noradrenergic neurons. Tyrosine hydroxylase (a.k.a. tyrosine 3-monooxygenase) is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). L-DOPA is a precursor for dopamine, which, in turn, is a precursor for the important neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). Tyrosine hydroxylase catalyzes the rate limiting step in this synthesis of catecholamines. In humans, tyrosine hydroxylase is encoded by the TH gene, and the enzyme is present in the central nervous system (CNS), peripheral symphatic neurons and the adrenal medulla. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing. Tyrosine hydroxylase, phenylalanine hydroxylase and tryptophan hydroxylase together make up the family of aromatic amino acid hydroxylases (AAAHs). http://en.wikipedia.org/wiki/Tyrosine_hydroxylase
Catalog Number:
(10799-474)
Supplier:
Rockland Immunochemical
Description:
14-3-3θ (also known as tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide) is a member of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. Through interaction with ASK1, c-jun NH-terminal kinase, and p38 mitogen-activated protein kinase (MAPK), 14-3-3θ plays an important role in controlling apotopsis (1). Induced expression of 14-3-3θ protein has been reported in patients with amyotrophic lateral sclerosis. Additionally, 14-3-3θ has been observed to mediate nucleocytoplasmic shuttling of the N protein (coronavirus nucleocapsid protein) which causes severe acute respiratory syndrome (2). 14-3-3θ Protein is ideal for investigators involved in Cell Stress& Chaperone Proteins, AKT/PKB Pathway, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, and WNT Signaling research.
Catalog Number:
(10261-594)
Supplier:
Bioss
Description:
SPR, also known as sepiapterin reductase, is a homodimeric cytoplasmic protein that belongs to the sepiapterin reductase family. SPR functions as an NADH-dependent aldo-keto reductase and specifically catalyzes the reduction of pteridine derivatives. In addition, SPR plays an important role in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the final reduction step of the synthesis pathway. BH4 is an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, tyrosine and phenylalanine) and is required for proper dopamine synthesis. Mutations in the gene encoding SPR can cause sepiapterin reductase deficiency, a monoamine neurotransmitter deficiency without hyperphenylalaninemia. Sepiapterin reductase deficiency interferes with BH4 synthesis, resulting in DOPA-responsive dystonia and a variety of other human diseases. In addition, SPR mRNA expression is increased in the brain of Parkinson’s Disease (PD) patients, suggesting that SPR may play a role in PD.
Catalog Number:
(10261-588)
Supplier:
Bioss
Description:
SPR, also known as sepiapterin reductase, is a homodimeric cytoplasmic protein that belongs to the sepiapterin reductase family. SPR functions as an NADH-dependent aldo-keto reductase and specifically catalyzes the reduction of pteridine derivatives. In addition, SPR plays an important role in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the final reduction step of the synthesis pathway. BH4 is an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, tyrosine and phenylalanine) and is required for proper dopamine synthesis. Mutations in the gene encoding SPR can cause sepiapterin reductase deficiency, a monoamine neurotransmitter deficiency without hyperphenylalaninemia. Sepiapterin reductase deficiency interferes with BH4 synthesis, resulting in DOPA-responsive dystonia and a variety of other human diseases. In addition, SPR mRNA expression is increased in the brain of Parkinson’s Disease (PD) patients, suggesting that SPR may play a role in PD.
Catalog Number:
(CH01386-25G)
Supplier:
CHEM-IMPEX INTERNATIONAL, INC
Description:
NA-BOC-L-TRYPTOPHAN 25G
Catalog Number:
(CH01386-5G)
Supplier:
CHEM-IMPEX INTERNATIONAL, INC
Description:
NA-BOC-L-TRYPTOPHAN 5G
Catalog Number:
(CH01387-25G)
Supplier:
CHEM-IMPEX INTERNATIONAL, INC
Description:
NA-BOC-D-TRYPTOPHAN 25G
Catalog Number:
(CH01387-100G)
Supplier:
CHEM-IMPEX INTERNATIONAL, INC
Description:
NA-BOC-D-TRYPTOPHAN 100G
Catalog Number:
(CH03492-5G)
Supplier:
CHEM-IMPEX INTERNATIONAL, INC
Description:
NIN-BOC-L-TRYPTOPHAN-2-C 5G
Catalog Number:
(CH04453-5G)
Supplier:
CHEM-IMPEX INTERNATIONAL, INC
Description:
NIN-BOC-L-TRYPTOPHAN 5G
Catalog Number:
(104017-272)
Supplier:
Indofine Chemical Company
Description:
NIN-BOC-L-TRYPTOPHAN 1GM
Catalog Number:
(CH01387-250G)
Supplier:
CHEM-IMPEX INTERNATIONAL, INC
Description:
NA-BOC-D-TRYPTOPHAN 250G
Catalog Number:
(CH01386-250G)
Supplier:
CHEM-IMPEX INTERNATIONAL, INC
Description:
NA-BOC-L-TRYPTOPHAN 250G
Catalog Number:
(CH03492-25G)
Supplier:
CHEM-IMPEX INTERNATIONAL, INC
Description:
NIN-BOC-L-TRYPTOPHAN-2-C 25G
Catalog Number:
(CH03492-1G)
Supplier:
CHEM-IMPEX INTERNATIONAL, INC
Description:
NIN-BOC-L-TRYPTOPHAN-2-C 1G
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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