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Ditetradecyl-3,3\'-thiodipropionate
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Ditetradecyl-3,3\'-thiodipropionate
Catalog Number:
(103334-046)
Supplier:
Novus Biologicals
Description:
The 14-3-3 gamma Antibody (6A10) from Novus Biologicals is a mouse monoclonal antibody to 14-3-3 gamma. This antibody reacts with human, mouse, rat. The 14-3-3 gamma Antibody (6A10) has been validated for the following applications: Western Blot, ELISA.
Catalog Number:
(101931-472)
Supplier:
Matrix Scientific
Description:
MF=C16H15N5S MW=309.40 MDL=MFCD06603439 ,500Mg
Catalog Number:
(10349-798)
Supplier:
Bioss
Description:
Members of the 14-3-3 family of proteins are highly conserved proteins, localized in neurons, and are axonally transported to the nerve terminals. They are also present, at lower levels, in various other eukaryotic tissues. 14-3-3 proteins appear to play important roles in a variety of signal transduction pathways, including those involved in cell cycle regulation and cell survival. Because 14-3-3 proteins bind to specific phosphoserine-containing sequences they are likely to have an important role in signaling pathways mediated by serine/threonine protein kinases. Evidence indicates 14-3-3 is required for Raf 1 kinase activity and phosphorylation amoung many other functions.
Supplier:
AMBEED, INC
Description:
(S)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride 98%
Catalog Number:
(102895-140)
Supplier:
TCI America
Description:
CAS Number: 527-17-3
MDL Number: MFCD00001604 Molecular Formula: C10H12O2 Molecular Weight: 164.20 Purity/Analysis Method: >98.0% (GC) Form: Crystal Color: Pale Yellow Melting point (°C): 112
Catalog Number:
(10280-084)
Supplier:
Bioss
Description:
14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibition of G2/M cell cycle progression. Multiple isoforms of 14-3-3 s exist due to alternative splicing events.
Catalog Number:
(102519-086)
Supplier:
Matrix Scientific
Description:
MF=C9H8CLNO4 MW=229.62 MDL=MFCD20487013 250MG
Catalog Number:
(101918-020)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 059372-250MG , MDL Number: MFCD18803484
Catalog Number:
(10283-874)
Supplier:
Bioss
Description:
14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 b, g, e, z, h, q and s. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins; by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity, and facilitation of protein modification. Loss of expression contributes to a vast array of pathogenic cellular activities.
Supplier:
AMBEED, INC
Description:
6-Fluoro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 97%
Catalog Number:
(76707-408)
Supplier:
AFG BIOSCIENCE LLC
Description:
Mouse 14-3-3 Protein Epsilon(YWHAE) ELISA Kit
Catalog Number:
(10280-082)
Supplier:
Bioss
Description:
14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibition of G2/M cell cycle progression. Multiple isoforms of 14-3-3 s exist due to alternative splicing events.
Catalog Number:
(101931-106)
Supplier:
Matrix Scientific
Description:
MF=C11H12N2O2 MW=204.23 Cas=5973-23-9 MDL=MFCD11058147 ,500Mg
Catalog Number:
(TCD0638-025G)
Supplier:
TCI America
Description:
CAS Number: 89-39-4
MDL Number: MFCD00024211 Molecular Formula: C8H9NO4 Molecular Weight: 183.16 Purity/Analysis Method: >99.0% (GC) Form: Crystal Boiling point (°C): 169 Melting point (°C): 72
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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