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Spiro[isochroman-1,4\\\'-piperidine]+hydrochloride
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Spiro[isochroman-1,4\\\'-piperidine]+hydrochloride
Catalog Number:
(10751-744)
Supplier:
Prosci
Description:
FLT3 Antibody: FLT3 is a member of the class III receptor tyrosine kinase family and its internal tandem duplication (ITD) is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. It is a membrane bound glycosylated protein that is expressed primarily in early hematopoietic progenitor cells. Upon binding its ligand FL, FLT3 activates multiple signaling pathways including the PI3K/Akt and Ras/MEK/MAPK pathways. In cells expressing FLT3-ITD, these pathways are constitutively on, resulting in abnormal cell growth and anti-apoptotic activity.
Supplier:
BeanTown Chemical
Description:
CAS: 464-07-3; EC No: 207-347-9; MDL No: MFCD00004522; RTECS: EL2276000
UN No: UN1987; Haz Class: 3; Packing Group: III
Liquid; Linear Formula: (CH3)3CCH(OH)CH3; Molecular Formula: C6H14O; MW: 102.17
Melting Point: 4.8°; Boiling Point: 119-121°; Flash point: 26°C (79°F)
Density (g/mL): 0.812; Refractive Index: 1.415
Supplier:
BeanTown Chemical
Description:
CAS: 7378-99-6; EC No: 230-939-3; MDL No: MFCD00009558
UN No: UN2922; Haz Class: 8 (6.1); Packing Group: III
Liquid; Linear Formula: CH3(CH2)7N(CH3)2; Molecular Formula: C10H23N; MW: 157.30
Melting Point: -57°; Boiling Point: 195°; Flash point: 64°C (147°F)
Density (g/mL): 0.765; Refractive Index: 1.424
Air Sensitive
Catalog Number:
(BT215805-5G)
Supplier:
BeanTown Chemical
Description:
CAS: 56773-42-3; EC No: 260-375-3; MDL No: MFCD00066497; RTECS: KH3154250
UN No: UN2811; Haz Class: 6.1; Packing Group: III
Powder; Linear Formula: CF3(CF2)7SO3N(CH2CH3)4; Molecular Formula: C16H20F17NO3S; MW: 629.37
Melting Point: 184-190°
Hygroscopic
Supplier:
Thermo Scientific Chemicals
Description:
Used in dry filling for thermal insulation of electrical furnaces.
Catalog Number:
(89268-262)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to SYT3 (N-terminal)
Supplier:
Spectrum Chemicals
Description:
Calcium Phosphate, Tribasic, Powder, FCC is used in powdered spices as an anticaking agent, a raising agent, an antacid and nutritional supplement. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food Grade (FCC) chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
Catalog Number:
(EM1.08525.0100)
Supplier:
BeanTown Chemical
Description:
CAS: 23254-43-5; EC No: 231-847-6; MDL No: MFCD00149682
UN No: UN3077; Haz Class: 9; Packing Group: III
Crystalline Aggregates; Linear Formula: CuSO4·xH2O; MW: 159.60 (anhydrous)
Melting Point: 110° (decomposes)
Density (g/mL): 2.27
Catalog Number:
(76012-394)
Supplier:
Prosci
Description:
This gene encodes a protein which is part of the ubiquinol-cytochrome c oxidoreductase complex which contains ten nuclear-encoded and one mitochondrial-encoded subunits. The encoded protein binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. Mutations in this gene are associated with mitochondrial complex III deficiency. A pseudogene has been described on the X chromosome.
Catalog Number:
(76084-280)
Supplier:
Bioss
Description:
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1.
Catalog Number:
(10464-554)
Supplier:
Bioss
Description:
EphA3 is a member of the Ephrin (Eph) family. The Ephrins and Eph-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the Ephrin A (EphA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the Ephrin B (EphB) class, which are transmembrane proteins. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats.
Catalog Number:
(10082-248)
Supplier:
Proteintech
Description:
Vimentin, also named as VIM, belongs to the intermediate filament family. Vimentin is class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is important for stabilizing the architecture of the cytoplasm. Monocyte-derived macrophages secrete vimentin into the extracellular space in vitro. Secretion of vimentin was enhanced by the proinflammatory cytokine tumor necrosis factor-alpha (TNFA; 191160) and inhibited by the antiinflammatory cytokine IL10 (124092), suggesting that vimentin is involved in the immune response. Vimentin has specialized functions that contribute to specific dynamic cellular processes.
Catalog Number:
(10464-556)
Supplier:
Bioss
Description:
EphA3 is a member of the Ephrin (Eph) family. The Ephrins and Eph-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the Ephrin A (EphA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the Ephrin B (EphB) class, which are transmembrane proteins. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats.
Catalog Number:
(10049-378)
Supplier:
Enzo Life Sciences
Description:
Acetylation and methylation of lysine are important post-translational modifications that regulate numerous protein-protein and protein-DNA interactions. Lysine acetylation and methylation involves the transfer of acetylCoA, or one or more methyl groups, to the e-amino group of lysine by modifying enzymes and cofactors. Histones and transcription factors are the primary targets of lysine acetylation and methylation, with either modification capable of inducing gene silencing or expression due to differential regulation of cofactors. For example, varying degrees of mono-, di-, and tri-methylation or acetylation of histone H3 at lysine residue 9 are known to demark distinct chromatin regions during various states of gene activation (methylation) or repression (acetylation).
Catalog Number:
(29280-506)
Supplier:
DWK Life Sciences (KIMBLE)
Description:
KIMAX® flask with a center neck that extends above the side necks.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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