N-(2-Azidoacetyl)-neuraminic+acid
Supplier:
AFG BIOSCIENCE LLC
Description:
N-(2-Azidoacetyl)-neuraminic acid ≥95%
Supplier:
AFG BIOSCIENCE LLC
Description:
2,4,7,8,9-Penta-O-acetyl-N-azidoacetyl-neuraminic acid methyl ester ≥95%
Supplier:
AFG BIOSCIENCE LLC
Description:
α-​Neuraminic acid, N-​acetyl-​2-​O-​(phenylmethyl)​-​, methyl ester, 4,​7,​8,​9-​tetraacetate ≥95%
Catalog Number:
(100291-404)
Supplier:
Indofine Chemical Company
Description:
Lipid Research 100mg 323.00 Room temperature.
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Catalog Number:
(77694-460)
Supplier:
LGC STANDARDS
Description:
N-Glycolyl Neuraminic Acid, TRC, LGC Standards
Supplier:
AFG BIOSCIENCE LLC
Description:
2-​O-​Methyl-​β-​D-​N-​acetylneuraminic Acid ≥95%
Supplier:
AFG BIOSCIENCE LLC
Description:
2-O-Methyl-α-D-N-acetylneuraminic acid ≥95%
Supplier:
MP Biomedicals
Description:
One unit will liberate 1.0 µmole of N-acetyl-neuraminic acid (NANA) per minute at pH 5.0 at 37°C, using either one NAN-lactose, bovine submaxillary mucin, or colominic acid as a substrate.
Catalog Number:
(76482-036)
Supplier:
AAT BIOQUEST INC
Description:
Neuraminidases, also called sialidases, are glycoside hydrolase enzymes that catalyze the hydrolysis of terminal sialic acid residues and neuraminic acid.
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Catalog Number:
(77976-630)
Supplier:
LGC STANDARDS
Description:
N-Acetyl-D-[1,2,3-13C3]neuraminic Acid, TRC, LGC Standards
Catalog Number:
(76120-256)
Supplier:
Bioss
Description:
Two families of mammalian lectin-like adhesion molecules bind glycoconjugate ligands in a sialic acid-dependent manner: the selectins and the sialoadhesins. The sialic acid-binding immunoglobulin superfamily lectins, designated siglecs or sialoadhesins, are immunoglobulin superfamily members recognizing sialylated ligands. The common sialic acids of mammalian cells are N-acetyl-neuraminic acid (Neu5Ac) and N-glycolyl-neuraminic acid (Neu5Gc). Siglec-1 mediates local cell-cell interactions in lymphoid tissues and can be detected at contact points of macrophages with other macrophages, sinus-lining cells and reticulum cells. Siglec-7, highly expressed in monocytes and resident blood cells, but not in parenchymatous cells, mediates inhibition of natural killer cell cytotoxicity. Siglec-9 is closely homologous to Siglec-7; the gene encoding it maps to chromosome 19q13.41 in humans. It is highly expressed in peripheral blood leukocytes (but not eosinophils), liver, bone marrow, placenta and spleen. Siglec-8, a type I membrane protein, is selectively expressed on human eosinophils, basophils and mast cells, where it regulates their function and survival.
Supplier:
AFG BIOSCIENCE LLC
Description:
N-azidoacetylgalactosamine 95%
Catalog Number:
(76120-254)
Supplier:
Bioss
Description:
Two families of mammalian lectin-like adhesion molecules bind glycoconjugate ligands in a sialic acid-dependent manner: the selectins and the sialoadhesins. The sialic acid-binding immunoglobulin superfamily lectins, designated siglecs or sialoadhesins, are immunoglobulin superfamily members recognizing sialylated ligands. The common sialic acids of mammalian cells are N-acetyl-neuraminic acid (Neu5Ac) and N-glycolyl-neuraminic acid (Neu5Gc). Siglec-1 mediates local cell-cell interactions in lymphoid tissues and can be detected at contact points of macrophages with other macrophages, sinus-lining cells and reticulum cells. Siglec-7, highly expressed in monocytes and resident blood cells, but not in parenchymatous cells, mediates inhibition of natural killer cell cytotoxicity. Siglec-9 is closely homologous to Siglec-7; the gene encoding it maps to chromosome 19q13.41 in humans. It is highly expressed in peripheral blood leukocytes (but not eosinophils), liver, bone marrow, placenta and spleen. Siglec-8, a type I membrane protein, is selectively expressed on human eosinophils, basophils and mast cells, where it regulates their function and survival.
Catalog Number:
(76120-962)
Supplier:
Bioss
Description:
The bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE/Mnk), or GLCNE, regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. GLCNE is required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. It is upregulated after PKC-dependent phosphorylation and is most abundantly expressed in liver and placenta. It is also expressed, to a lesser extent, in heart, brain, lung, kidney, skeletal muscle and pancreas. Defects in GLCNE are the cause of sialuria, inclusion body myopathy 2 (IBM2) and Nonaka myopathy (NM) or distal myopathy with rimmed vacuoles (DMRV). Sialuria is an autosomal dominant disorder caused by a lack of feedback inhibition of GLCNE by CMP-NeuAc, resulting in overproduction of NeuAc. It is characterized by an accumulation of free sialic acid in the cytoplasm and large quantities of neuraminic acid in the urine. Both IBM2 and NM/DMRV are autosomal recessive neuromuscular disorders characterized by adult onset, distal and proximal muscle weakness (especially in the legs) and a typical muscle pathology including filamentous inclusions and rimmed vacuoles.
Supplier:
New England Biolabs (NEB)
Description:
Neuraminidase is the common name for Acetyl-neuraminyl hydrolase (Sialidase)
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