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N-(3-Acetyl-4-hydroxyphenyl)butyramide
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N-(3-Acetyl-4-hydroxyphenyl)butyramide
Catalog Number:
(77437-084)
Supplier:
Bioss
Description:
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH.
Catalog Number:
(97062-476)
Supplier:
Matrix Scientific
Description:
MF=C8H7Fo2 MW=154.14 Cas=394-32-1 MDL=MFCD00011668 100G
Catalog Number:
(103607-818)
Supplier:
Matrix Scientific
Description:
2-(4-HYDROXYPHENYL)BENZO[B] 094482-1G
Catalog Number:
(103625-118)
Supplier:
Matrix Scientific
Description:
3-(4-HYDROXYPHENYL)CHROMAN-7-OL 5G
Catalog Number:
(77440-178)
Supplier:
Bioss
Description:
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
Catalog Number:
(77977-287)
Supplier:
LGC STANDARDS
Description:
4-HYDROXYPHENYL 4-ISOPROPOXYPHENYL SU 5G
Catalog Number:
(77984-066)
Supplier:
LGC STANDARDS
Description:
2 2-BIS-(4-HYDROXYPHENYL)HEXAFLUORO 10MG
Catalog Number:
(76083-940)
Supplier:
Bioss
Description:
Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.
Catalog Number:
(89357-406)
Supplier:
Genetex
Description:
Tubulin is the major building block of microtubules. This intracellular cylindrical filamentous structure is present in almost all eukaryotic cells. Microtubules function as structural and mobility elements in mitosis, intracellular transport, flagellar movement, and in the cytoskeleton. Tubulin is a heterodimer which consists of alpha tubulin and beta tubulin; both subunits have a molecular weight of 55 kDa and share considerable homology. The most widely studied tubulins have been isolated from vertebrate brains. The microtubules can be viewed in immunofluorescent microscopy allowing for the observation of the intracellular organization of proteins that are in the form of a supramolecular structure. Distinct classes of interphase microtubules have been described in tissue culture cells. They contain post translationally modified subunits of tubulin, detyrosinated alpha tubulin (Glutubulin) or acetylated alpha tubulin. The dynamic properties of microtubules of the Tyrtubulin type studied in living cells have suggested that they turnover and grow very rapidly in vivo with most microtubules exchanging within a half-time of approximately 10 minutes. Minor subpopulations of interphase microtubules have been found to be more stable in that they resist exchange for several hours, or that they are less sensitive to microtubule disrupting drugs. The coding portion of genes encoding alpha tubulin terminates in a tyrosine codon indicating that the primary gene product is tyrosinated (Tyr-Tu). Tubulin tyrosinylation is involved in the assembly status of tubulin. A specific tubulinyl tyrosine carboxypeptidase removes the terminal tyrosine to yield an alpha tubulin terminating in a glutamic acid residue while another enzyme modifies the alpha tubulin by addition of tyrosine to the carboxy terminus to offer a potential cycle of tyrosine addition and loss.
Catalog Number:
(103651-888)
Supplier:
Matrix Scientific
Description:
1-(3-AMINO-2-HYDROXYPHENYL)ETHANONE 5G
Catalog Number:
(77885-153)
Supplier:
AMBEED, INC
Description:
(2-CHLORO-5-HYDROXYPHENYL)BORONICACID 5G
Catalog Number:
(103654-156)
Supplier:
Matrix Scientific
Description:
2-[(4-HYDROXYPHENYL)FORMAMI 136231-5G
Catalog Number:
(77937-469)
Supplier:
AOB CHEM USA
Description:
(2-CHLOROPHENYL)(4-HYDROXYPHENYL)ME 5G
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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