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N-(Cyclopentylcarbonyl)-beta-alanine
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N-(Cyclopentylcarbonyl)-beta-alanine
Catalog Number:
(76080-522)
Supplier:
Bioss
Description:
The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. The insulin receptor exhibits receptor tyrosine kinase (RTK) activity. RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism.Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.
Supplier:
ANTIBODIES.COM LLC
Description:
Rabbit monoclonal [ARC56185] antibody to IL-1 beta for WB with samples derived from Mouse.
Supplier:
AMBEED, INC
Description:
Fmoc-ß-HoVal-OH, Purity: 98%, CAS number: 172695-33-9, Appearance: White to Yellow Solid, Storage: Sealed in dry, 2-8C, Size: 100MG
Catalog Number:
(76193-980)
Supplier:
Prosci
Description:
This mAb reacts with a protein of 22kDa, identified as beta sub-unit of FSH. It does not cross react with the alpha sub-unit. Follicle stimulating hormone (FSH) is a hormone synthesized and secreted by gonadotrophs in the anterior pituitary gland. In the ovary, FSH stimulates the growth of immature Graafian follicles to maturation. As the follicle grows, it releases inhibin, which deactivates the FSH production. In men, FSH enhances the production of androgen-binding protein by the Sertoli cells of the testis and is critical for spermatogenesis. FSH and LH act synergistically in reproduction. FSH is a useful marker in the classification of pituitary tumors and the study of pituitary disease.
Supplier:
BeanTown Chemical
Description:
CAS: 936-59-4; EC No: 213-317-6; MDL No: MFCD00000990
Crystalline; Molecular Formula: C9H9ClO; MW: 168.62
Melting Point: 48-50°; Boiling Point: 113-115°/4 mmHg; Flash point: <gt/>110°C (<gt/>230°F)
Catalog Number:
(77179-648)
Supplier:
ANTIBODIES.COM LLC
Description:
Mouse monoclonal [FSHB/6845] antibody to FSH beta for IHC-P with samples derived from Human.
Catalog Number:
(76962-148)
Supplier:
ANTIBODIES.COM LLC
Description:
Mouse monoclonal [HCGb/54+ HCGb/459] antibody to HCG beta for IHC-P with samples derived from Human.
Catalog Number:
(RL100-101-237)
Supplier:
Rockland Immunochemical
Description:
This product has been assayed against 1.0 µg of b -Phosphoglucomutase (Lactococcus lacti) in a standard ELISA using Peroxidase conjugated Affinity Purified anti-Goat IgG (H&L) (Rabbit) and ABTS (2,2’-azino-bis-[3-ethylbenthiazoline-6-sulfonic acid])
Supplier:
ANTIBODIES.COM LLC
Description:
Rabbit polyclonal antibody to SNAP-beta for WB with samples derived from Human, Mouse and Rat.
Catalog Number:
(77179-966)
Supplier:
ANTIBODIES.COM LLC
Description:
Mouse monoclonal [IL1B/4651] antibody to IL-1 beta for ELISA and IHC-P with samples derived from Human.
Catalog Number:
(77179-964)
Supplier:
ANTIBODIES.COM LLC
Description:
Mouse monoclonal [IL1B/4650] antibody to IL-1 beta for ELISA and IHC-P with samples derived from Human.
Catalog Number:
(10247-296)
Supplier:
Bioss
Description:
Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling.
Catalog Number:
(76701-530)
Supplier:
AFG BIOSCIENCE LLC
Description:
Mouse T-cell Surface Glycoprotein CD8 beta Chain(CD8B) ELISA Kit
Catalog Number:
(76083-296)
Supplier:
Bioss
Description:
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Catalog Number:
(76951-712)
Supplier:
ANTIBODIES.COM LLC
Description:
Recombinant rabbit monoclonal [CTNNB1/2030R] antibody to beta Catenin for Flow Cytometry, IF, WB and IHC-P with samples derived from Human.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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