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N-Octanoyl-L-homoserine+lactone
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N-Octanoyl-L-homoserine+lactone
Supplier:
Bachem Americas
Description:
Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary through a G protein-coupled receptor (GHS-R). Recently, ghrelin ("ghre" is the Proto-Indo-European root of the word "grow") has been identified as an endogenous ligand for GHS-R. These peptides consist of 28 amino acids with an octanoyl-residue at Ser³, which is essential for expressing activity. Ghrelin stimulates GH release from rat primary culture pituitary cells in a dose-dependent manner and induces an increase in intracellular Ca²⁺ in GHS-R-expressing cells with an EC₅₀ value of 2.5 nM. Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin. In future, ghrelin might be used in the treatment of aging patients as well as in patients with idiopathic GH deficiency, obesity, osteoporosis or cardiovascular diseases.
Catalog Number:
(H-6334.0500BA)
Supplier:
Bachem Americas
Description:
Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary through a G protein-coupled receptor (GHS-R). Recently, ghrelin ("ghre" is the Proto-Indo-European root of the word "grow") has been identified as an endogenous ligand for GHS-R. These peptides consist of 28 amino acids with an octanoyl-residue at Ser³, which is essential for expressing activity. Ghrelin stimulates GH release from rat primary culture pituitary cells in a dose-dependent manner and induces an increase in intracellular Ca²⁺ in GHS-R-expressing cells with an EC₅₀ value of 2.5 nM. Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin. In future, ghrelin might be used in the treatment of aging patients as well as in patients with idiopathic GH deficiency, obesity, osteoporosis or cardiovascular diseases.
Supplier:
AMBEED, INC
Description:
H-DL-HoSer-OH, Purity: 98%, CAS Number: 1927-25-9, Appearance: White to Yellow Powder or Crystals, Storage: Keep in dark place, Inert atmosphere, Room temperature, Size: 5G
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 042293-1G , MDL Number: MFCD01862866
Catalog Number:
(103276-808)
Supplier:
Novus Biologicals
Description:
The LIPT2 Antibody from Novus Biologicals is a rabbit polyclonal antibody to LIPT2. This antibody reacts with human. The LIPT2 Antibody has been validated for the following applications: Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.
Supplier:
AMBEED, INC
Description:
Fmoc-HomoSer(TBDMS)-OH ≥95%
Supplier:
Bachem Americas
Description:
Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary through a G protein-coupled receptor (GHS-R). Recently, ghrelin ("ghre" is the Proto-Indo-European root of the word "grow") has been identified as an endogenous ligand for GHS-R. These peptides consist of 28 amino acids with an octanoyl-residue at Ser³, which is essential for expressing activity. Ghrelin stimulates GH release from rat primary culture pituitary cells in a dose-dependent manner and induces an increase in intracellular Ca²⁺ in GHS-R-expressing cells with an EC₅₀ value of 2.5 nM. Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin. In future, ghrelin might be used in the treatment of aging patients as well as in patients with idiopathic GH deficiency, obesity, osteoporosis or cardiovascular diseases.
Catalog Number:
(89141-448)
Supplier:
Enzo Life Sciences
Description:
Ghrelin is a multifunctional peptide hormone secreted from the anterior pituitary known to affect many physiological processes including the release of growth hormone, appetite regulation, gastric acid secretion, gastrointestinal motility, and blood pressure regulation. The 28 amino acid ghrelin peptide is modified at Ser3 by addition of a fatty acid group (i.e., n-octanoyl) that is essential for its biological activity. The ghrelin receptor (GHS-R) is a seven transmembrane (7-TM) GPCR that is expressed in the hippocampus, pituitary, and hypothalamus, as well as in peripheral tissues including the heart, lung, liver, kidney, pancreas, intestines, and immune cells. Ghrelin signals are primarily relayed via coupling of the GHS-R to Gq/11 alpha subunits, promoting stimulation of phospholipase C, and an increase in intracellular calcium. Stimulation of adenylyl cyclases and increased cAMP are also induced by GHS-R activation. In humans and swine, two splice variants of the ghrelin receptor are expressed from the same gene. The GHS-R 1(a) receptor is the 366 amino acid, 7-TM form, while GHS-R 1(b) is a 289 amino acid, 5-TM form that is truncated at the C-terminus and is pharmacologically inactive. The epitope recognized by this antibody is unaffected by alternative splicing.
Supplier:
Spectrum Chemicals
Description:
Glucono delta-Lactone, FCC is used as a sequestrant, a leavening agent, and an acidifier. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
Supplier:
AMBEED, INC
Description:
5-Hydroxynorbornane-2,6-lactone 98%
Supplier:
Thermo Scientific Chemicals
Description:
2,3-O-Isopropylidene-D-ribonic acid-1,4-lactone, 97+%. Powder.
Supplier:
AMBEED, INC
Description:
D-Gulonic acid-γ-lactone 97%
Supplier:
AMBEED, INC
Description:
(-)-Corey lactone benzoate 97%
Supplier:
TCI America
Description:
Atorvastatin Lactone 95,0 HPLC_ASSAY_METHOD
Supplier:
AMBEED, INC
Description:
D-Glucono-1,5-lactone ≥98%
Catalog Number:
(EM8.43794.0100)
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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